1st Edition
Pharmacokinetics in Drug Discovery and Development
Edited By Ronald D. Schoenwald
Copyright 2002
440 Pages
50 B/W Illustrations
by
CRC Press
440 Pages
by
CRC Press
Also available as eBook on:
Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics... Read more
BASIC PRINCIPLES
Basic Principles
INDUSTRIAL AND REGULATORY APPLICATIONS
PK/PD Approach
Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development
Phase I, II, and III FDA Submissions
Bioavailability and Bioequivalence
CLINICAL APPLICATIONS
General Approaches to Clinical Pharmacokinetic Monitoring
Aminoglycosides and Other Antibiotics
Cardiovascular Agents
Psychotropic Agents
Theophylline
Anticonvulsant Agents
RESEARCH APPLICATIONS
Classical Modeling
Noncompartmental Modeling, An Overview
Physiologically-Based Pharmacokinetic Models
Population Pharmacokinetics
The Linear Systems Approach
Basic Principles
INDUSTRIAL AND REGULATORY APPLICATIONS
PK/PD Approach
Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development
Phase I, II, and III FDA Submissions
Bioavailability and Bioequivalence
CLINICAL APPLICATIONS
General Approaches to Clinical Pharmacokinetic Monitoring
Aminoglycosides and Other Antibiotics
Cardiovascular Agents
Psychotropic Agents
Theophylline
Anticonvulsant Agents
RESEARCH APPLICATIONS
Classical Modeling
Noncompartmental Modeling, An Overview
Physiologically-Based Pharmacokinetic Models
Population Pharmacokinetics
The Linear Systems Approach
Biography
Ronald D. Schoenwald
"well written, making many of the approaches understandable even if, like me, the reader is not mathematically gifted. Certainly, this section has stimulated my desire to learn more, and like the Clinical Application section, I will be referring to it regularly"
- Peter Lawrence, AstraZeneca, UK, BTS Newsletter, Spring 2003
"The authors intend to provide a basic understanding and overview of numerous areas within pharmacokinetics...For anyone with a solid initial training in the field, however, this book should function quite well as a refresher on familiar areas and, more to the intended point, as an introduction to subspecialty areas."
-Gregory Reed, PhD, University of Kansas Medical Center
