Photoacoustic Tomography  book cover
1st Edition

Photoacoustic Tomography

ISBN 9781482261035
Published December 16, 2014 by CRC Press
304 Pages 32 Color & 186 B/W Illustrations

USD $210.00

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Book Description

The concept of photoacoustic tomography (PAT) emerged in the mid-1990s, and the field of PAT is now rapidly moving forward. Presenting the research of a well-respected pioneer and leading expert, Photoacoustic Tomography is a first-of-its-kind book covering the underlying principles and practical applications of PAT in a systematic manner. Written in a tutorial format, the text:

  • Addresses the fundamentals of PAT, the theory on photoacoustic effect, image reconstruction methods, and instrumentation
  • Details advanced methods for quantitative PAT, which allow the recovery of tissue optical absorption coefficient and/or acoustic properties
  • Explores the development of several image-enhancing schemes, including both software and hardware approaches
  • Examines array-based PAT systems that are the foundation for the realization of 2-D, 3-D, and 4-D PAT
  • Discusses photoacoustic microscopy (PAM) and combinations of PAT/PAM with other imaging methods
  • Considers contrast-agents-based molecular PAT, with both nontargeted and cell receptor–targeted methods
  • Describes clinical applications and animal studies in breast cancer detection, osteoarthritis diagnosis, seizure localization, intravascular imaging, and image-guided cancer therapy

Photoacoustic Tomography is an essential reference for graduate students, researchers, industry professionals, and those who wish to enter this exciting field.

Table of Contents


About the Author

Fundamentals of Photoacoustic Tomography

Photoacoustic Effect

Empirical Description

Rigorous Theory

Image Reconstruction Methods

Delay-and-Sum Beam Forming Algorithm

Iterative Nonlinear Algorithm

A-Line/B-Mode Image Formation Method


Quantitative Photoacoustic Tomography

Recovery of Optical Absorption Coefficient: Method 1

Recovery of Optical Absorption Coefficient: Method 2

Recovery of Optical Absorption Coefficient: Method 3

Recovery of Optical Absorption Coefficient: Method 4

Simultaneous Recovery of Optical Absorption Coefficient and Acoustic Velocity

Multispectral PAT

Image Enhancement Software and Hardware Approaches

Dual Mesh Scheme

Adjoint Sensitivity Method

Total-Variation-Minimization Scheme

Mathematical Derivations

Examples: Reduction of Noise Effect

Examples: Image Reconstruction from Few-Detector and Limited-Angle Data

Radiative Transfer Equation

The RTE and Its Finite Element Discretization

The RTE-Based Quantitative PAT

Results and Discussion

Parallel Computation

Variable-Thickness Multilayered Polyvinylidene Fluoride Transducer

AlN-Based Piezoelectric Micromachined Ultrasonic Transducer

Liquid Acoustic Lens

Microelectromechanical Systems Scanning Mirror

Photoacoustic Imaging System

Results and Discussion

Transducer Array-Based Photoacoustic Tomography: 2-D, 3-D, and 4-D Photoacoustic Imaging

Array-Based PAT System and 2-D Imaging

Laser Source

Full-Ring Ultrasound Transducer Array

Control Electronics and Data Acquisition

System Evaluation and Experimental Studies

3-D Imaging

System Description

Phantom Experiments

In Vivo Experiments

4-D Imaging

Drug Delivery Monitoring

Tumor Therapy Monitoring

Photoacoustic Microscopy and Photoacoustic Computed Microscopy

Optical-Resolution Photoacoustic Microscopy

Acoustic-Resolution Photoacoustic Microscopy

C-Scan Photoacoustic Microscopy

Materials and Methods

Results and Discussion

Photoacoustic Computed Microscopy




Photoacoustic Microscopy Based on Acoustic Lens with Variable Focal Length

Confocal Photoacoustic Microscopy Using a Single Multifunctional Lens

Multimodal Approaches


Material and Methods

Results and Discussion



Results and Discussion


Optical-Resolution PAM/OCT

Materials and Methods

Results and Discussion

Contrast-Agents-Based Molecular Photoacoustic Tomography

Gold Nanoparticles

Graphene Nanosheets

Urokinase Plasminogen Activator Receptor (uPAR)–Targeted Magnetic Iron Oxide Nanoparticles (NIR830-ATF-IONP)

Material and Methods



HER-2/neu Targeted Magnetic Iron Oxide Nanoparticles for Dual-Modal Photoacoustic and Fluorescence Molecular Tomography (PAT/FMT) of Ovarian Cancer




Clinical Applications and Animal Studies

Joint Imaging

2-D Single-Spectral Quantitative PAT

2-D Multispectral Quantitative PAT

3-D Single-Spectral Quantitative PAT

3-D Multispectral Quantitative PAT

Intraoperative Imaging

Intraoperative Photoacoustic Tomography (iPAT) System

Results and Discussion

Brain Imaging


Results and Discussion

Imaging of Tumor Vasculature Development


Results and Discussion

Intravascular Imaging

Breast Imaging

Photoacoustic Tomography System

Clinical Experiments


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Huabei Jiang, Ph.D, is J. Crayton Pruitt family professor in the Department of Biomedical Engineering at the University of Florida, Gainesville, USA. He has published more than 300 peer-reviewed scientific articles and patents. Dr. Jiang is a fellow of the Optical Society of America (OSA), a fellow of the International Society of Optical Engineering (SPIE), and a fellow of the American Institute of Medical and Biological Engineering (AIMBE).


"... a comprehensive accounting of photoacoustic imaging (PAI) methods and related technologies with emphasis on the author's own works. ... [a] timely addition to attract readers to this fascinating and relatively new area of research. The book uniquely covers the fundamentals of photoacoustic imaging with descriptions of basic physics, image reconstruction, software development, and implementation. The readers are also exposed to a short account of exogenous probes for PAI application and a few examples of PAI in clinical studies. The book provides a list of relevant references and further reading materials at the end of each chapter. The format of writing is tutorial and therefore I envision it as a reference text for graduate students, biomedical researchers, and engineers who want to embark into this exciting new imaging area."
—Dipanjan Pan, from IEEE Transactions on Medical Imaging, Vol. 34, No. 12, December 2015

"… a very comprehensive collection of photoacoustic imaging methods, covering everything from the basics of photoacoustic generation and image reconstruction methods to the various implementations, including numerous applications. This is the first time the topic of photoacoustic imaging has been covered in this detail by a single author."
—Günther Paltauf, Karl-Franzens-Universität Graz, Austria