1st Edition

Phyllanthus Species Scientific Evaluation and Medicinal Applications

Edited By Ramadasan Kuttan, K.B. Harikumar Copyright 2012
    392 Pages 7 Color & 41 B/W Illustrations
    by CRC Press

    392 Pages 7 Color & 41 B/W Illustrations
    by CRC Press

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    The genus Phyllanthus has over 1,000 species distributed worldwide, many of which have been used indigenously for the treatment of a variety of ailments for generations. Researchers have developed ways to analyze the potential of these plants and demonstrated the pharmacological action and various chemical entities present in each of them. They have validated the folklore claims and used this knowledge to design cost-effective and reliable sources of medicine.

    The first book to exclusively examine the genus Phyllanthus, Phyllanthus Species: Scientific Evaluation and Medicinal Applications begins with a systematic classification and identification manual for various plants in the genus, followed by the scientific evaluation of the species for modern medicinal use. This reference compiles cutting edge research from countries around the world, including the UK, Malaysia, India, Indonesia, Spain, Cuba, and China. Topics covered include phylogenetic analysis of Phyllanthus, chemistry of the genus, anti-cancer, anti-diabetic and chemo- protective effects, genotoxicity, clinical trials involving Phyllanthus, and various formulations containing different plants from the genus Phyllanthus.

    Phyllanthus Species: Scientific Evaluation and Medicinal Applications describes in detail the taxonomy, cultivation, and marketing, identification of geographic and genetic hot spots, chemistry, scientific evaluation, and clinical trials of various species of Phyllanthus. Written for researchers and educators in academia, industry, agriculture, and the interested general public, this book’s up-to-date references make it a powerful resource providing first-hand information on Phyllanthus.

    Taxonomy of the Genus Phyllanthus
    Sheeja T. Tharakan
    Identification Manual for Some Species of the Genus Phyllanthus L. of Phyllanthaceae with Special Reference to the Indian Subcontinent
    A. Lalithamba
    Current Pharmacopoeial Status of Phyllanthus Species: P. emblica, P. amarus, and P. fraternus
    Raman Mohan Singh and Vivekanandan Kalaiselvan
    Cultivation, Economics, and Marketing of Phyllanthus Species
    B. R. Rajeswara Rao
    Phylogenetic Analysis of Phyllanthus Species
    Srinivasu Tadikamalla
    Genetic Resources of Phyllanthus in Southern India: Identification of Geographic and Genetic Hot Spots and Its Implication for Conservation
    G. Ravikanth, R. Srirama, U. Senthilkumar, K. N. Ganeshaiah, and R. Uma Shaanker
    Phytochemistry of the Genus Phyllanthus
    Lutfun Nahar, Satyajit D. Sarker, and Abbas Delazar
    Hyphenated Techniques in the Study of the Genus Phyllanthus
    Satyajit D. Sarker, Lutfun Nahar, and Abbas Delazar
    Anti-inflammatory Activity of Various Species of Phyllanthus
    K. B. Harikumar and Ramadasan Kuttan
    Hepatoprotective Effects of Plants in the Family Phyllanthaceae
    V. V. Asha
    Anticancer Studies of Phyllanthus amarus
    K. B. Harikumar and Ramadasan Kuttan
    Anticancer Activity of Phyllanthus emblica
    Jeena Joseph and Ramadasan Kuttan
    The In Vivo and In Vitro Proapoptotic and Antiangiogenic Effects of Phyllanthus urinaria
    Jong‑Hwei S. Pang, Sheng-Teng Huang, Rong-Chi Yang, and Hsiao‑Ting Wu
    and Hepatitis B, Hepatitis C, and HIV Infections
    S. P. Thyagarajan
    Antiviral Activities of Phyllanthus orbicularis, an Endemic Cuban Species
    Gloria del Barrio and Francisco Parra
    Diabetes and Diabetic Complications and Phyllanthus species Geereddy Bhanuprakash Reddy and Palla Suryanarayana
    Chemoprotective, Genotoxic, and Antigenotoxic Effects of Phyllanthus Sp.
    Rakesh K. Johri
    Antiaging Effects of Phyllanthus Species
    Vasudevan Mani and Shanmugapriya Thulasimani
    Toxicity Studies of Phyllanthus Species
    K. N. S. Sirajudeen
    Clinical Trials Involving Phyllanthus Species
    Mulyarjo Dirjomuljono and Raymond R. Tjandrawinata
    Immunomodulatory Activity of Brahma Rasayana, an Herbal Preparation Containing Phyllanthus emblica as the Main Ingredient
    Praveen K. Vayalil, Ramadasan Kuttan, and Girija Kuttan
    Triphala: An Ayurvedic Drug Formulation.
    Sandhya T. Das and K. P. Mishra
    Kalpaamruthaa: A Successful Drug against Various Ailments
    P. Sachdanandam and P. Shanthi


    Ramadasan Kuttan, Ph.D., has worked at the Amala Cancer Research Center, Thrissur, Kerala, India since 1984 and presently is the Research Director of the Center. He earned his doctoral degree from the University of Madras in 1973, receiving a Gold Medal for the outstanding thesis of the year. From 1973 to 1984, he conducted research in the United States, including stints at Roche Institute of Molecular Biology, Nutley, New Jersey, and M. D. Anderson Hospital and Cancer Center in Houston, Texas. His major areas of research include cancer drugs from plant sources and chemoprevention, chemoprotection, radioprotection, immunomodulation, and the like. He has done extensive work on the use of Phyllanthus amarus in cancer using animal models and cell culture.

    K. B. Harikumar, Ph.D., received his bachelor’s and master’s degrees in biochemistry from Nagpur University in India. His doctoral research on cancer chemoprevention by natural products was conducted under the direction of Dr. Ramadasan Kuttan at Amala Cancer Research Center, affiliated with Mahatma Gandhi University at Kottayam in India. Presently, he is a postdoctoral associate in the Department of Biochemistry and Molecular Biology at Virginia Commonwealth University, Richmond, Virginia. He has over 40 peer-reviewed publications and several book chapters to his credit. His major research focuses are cancer chemoprevention, ubiquitination and nuclear factor kappa B signaling, and the role of bioactive lipids in cell signaling.