1st Edition

Physiological Optical Imaging

By Gennadi Saiko Copyright 2025
    240 Pages 18 Color & 17 B/W Illustrations
    by CRC Press

    Physiological optical imaging is a group of emerging technologies that aim to provide healthcare practitioners and biomedical researchers with information about tissue physiology or pathophysiology using approaches different from traditional medical imaging (PET, ultrasound, MRI, X-ray, or CT scan).

    This book provides a comprehensive review of this group of technologies, combing a current medical literature review with an overview of cutting-edge technologies, the physics behind them, and common features across different technologies. It presents technical and physiological considerations that impact the sensitivity and spatial resolution of each technology and practical ways to improve them. The book emphasises low-cost technologies, which can be implemented in Point-of-Care settings.It is illustrated primarily with examples from wound care and oncology, with additional examples from other medical fields, including ophthalmology and neuroimaging.

    It can be used as a one-stop reference and practical guide for healthcare professionals, clinical researchers, and engineers working with emerging bioimaging technologies who are looking to utilise physiological optical imaging technologies in biomedical research or clinical practice.

    Key Features:

    • Provides a comprehensive review of current technologies.
    • Written as a practical guide with physiological and design considerations and illustrations.
    • Presents a 360-degree view on the topic: a combination of clinical information alongside a technological background.

    Chapter 1: What is Physiological Optical Imaging? Chapter 2: Resolution of Physiological Optical Imaging Techniques. Chapter 3: Contrast Ratio in Physiological Optical Imaging. Chapter 4: Sampling Depth in Physiological Optical Imaging. Chapter 5: Absorption-Based Physiological Optical Imaging Techniques. Chapter 6: Scattering-Based Physiological Optical Imaging Techniques. Chapter 7: Fluorescence-Based Physiological Optical Imaging Techniques. Chapter 8: Thermographic Physiological Optical Imaging Techniques. Chapter 9: Vibrational and Terahertz Techniques in Physiological Optical Imaging. Chapter 10: Other Approaches in Physiological Optical Imaging. Chapter 11: Endoscopic Physiological Optical Imaging. Chapter 12: Microscopic Physiological Optical Imaging. Chapter 13: Future Directions in Physiological Optical Imaging. Appendix A: Surface Tissues Morphology. Appendix B: Light Propagation in Tissues.


    Gennadi Saiko is an accomplished scientist and entrepreneur with a successful track record in world-famous research institutes (Institute of General Physics, Moscow, Princess Margaret Hospital, Toronto), Fortune 500 companies (American Express), world-renown universities (Friedrich-Alexander-University of Erlangen-Nurnberg, Moscow Institute of Physics and Technology, Toronto Metropolitan University), and startups (Infinium Capital, Oxilight Inc, Swift Medical Inc). Gennadi has received MSc and Ph.D. in Physics from the Moscow Institute of Physics and Technology. His primary interest is in the development of innovative optical imaging modalities for healthcare, with primary focus on wound care, cardiology, emergency, and critical care. He combines both academic and industrial expertise. Gennadi has a successful experience in IP development and commercialization in MedTech. In particular, he developed a handheld multimodal imaging system primarily used in wound care, which Swift Medical Inc commercialized as Swift Ray 1. Gennadi authored more than 35 publications in peer-reviewed journals, two book, seven book chapters, and several patents. In addition, he delivered more than 30 presentations at international scientific conferences and chaired sessions at multiple international conferences. Gennadi is a reviewer at more than 20 peer-reviewed journals and serves on boards of several scientific journals. Gennadi is an Adjunct Professor of the Department of Physics at Toronto Metropolitan University (formerly Ryerson University).