Understanding phytochemical–gene interactions provides the basis for individualized therapies to promote health as well as prevent and treat disease. The authors of Phytochemicals: Nutrient–Gene Interactions examine the interactions between phytochemicals and the human genome and discuss the impact these interactions have on health, aging, and chronic conditions such as inflammation, heart disease, obesity, type II diabetes mellitus, and cancer.
Keeping pace with the most important trends in phytochemical research, the authors accentuate the latest understanding on the use of controlled clinical trials, new screening technologies, and the completed human genome project for researching the pharmacokinetics, safety, and efficacy of phytochemicals. The book covers a balanced range of topics beginning with experimental strategies and methodologies for identifying significant interactions between diet, genetic variants, and different markers of cardiovascular disease, inflammation, and obesity. Different authors explain the mechanisms of protective action that link diets rich in omega-3 fatty acids, unsaturated fats, fruits, vegetables, and whole grains with a decreased risk of chronic and degenerative diseases. They also review and summarize epidemiological research on plant-based foods and dietary patterns supporting the beneficial role of phytochemicals in health promotion and disease prevention.
Phytochemicals: Nutrient–Gene Interactions illustrates the growing role of nutrigenomics and nutrigenetics in disease prevention and in the responsible development of safe and effective phytochemical products within the food, pharmaceutical, and supplement industries.
Table of Contents
Nutrigenomics: Opportunities and Challenges. Gene–Diet Interactions, Blood Lipids, and Cardiovascular Disease Risk: The Rise of Nutrigenetics. Diet–Disease Interactions at the Molecular Level: An Experimental Paradigm. Anti-Inflammatory Phytochemicals: In Vitro and Ex Vivo Evaluation. Lipid Peroxidation, Gene Expression, and Resveratrol: Implications in Atherosclerosis. Adipose Tissue Gene Expression in the Context of Inflammation and Obesity. Gene–Environment Interactions in Obesity: Implications for the Prevention and Treatment of Obesity. Saturated Fat Consumption in Ancestral Human Diets: Implications for Contemporary Intakes. Plant-Based Diets and Prevention of Cardiovascular Disease: Epidemiologic Evidence. Evolutionary Aspects of Diet, the Omega-6/Omega-3 Ratio, and Gene Expression. Beyond Fiber: Whole Grains and Health. Molecular Activities of Vitamin E.
Mark S. Meskin, Wayne R. Bidlack, R. Keith Randolph