Phytochemistry of Plants of Genus Cassia
Cassia is an indigenous plant in Africa, Latin America, Northern Australia and Southeast Asia. Several Cassia species are of high commercial and medicinal significance since they are used as spices and in traditional medicines. Currently plants from genus Cassia is in great demand due to their immense medicinal properties. Cassia species have various pharmacological activities such as antibacterial, analgesic, antiinflammatory, antiarthritic, hepatoprotective, antitumor, antifertility, antifungal, antioxidant, antileishmaniatic, antimicrobial, CNS and hypoglycaemic activitiy. Different class of compounds reported from Cassia species are anthraquinones, phenolics, flavonoids, chromenes, terpenes, proanthocyanidins, coumarins, chromones and lignans. The taxonomy and nomenclature of Cassia species are quite complex. It is very difficult to differentiate them due to their overlapping morphological characters and close similarities. This usually leads to misidentification and misinterpretation of the components.
- Presents collection of Ayurvedic features and scientific evidence of most important medicinal plants of Cassia species
- Chemical signatures for identification of Cassia species
- Easy to use analytical procedure for quality control of Cassia species and its products.
1.1. Introduction. 1.2. Geographical Distribution of genus Cassia. 1.2. Phytography of genus Cassia. 1.3. Phytochemistry of genus Cassia. 1.4. Pharmacological activities of genus Cassia. 1.5. Traditional uses of genus Cassia. 1.6. Introduction of Selected Cassia Species. 2. Qualitative and Quantitative Determination of Bioactive phytochemicals in selected Cassia Species using HPLC-ESI-QTOF-MS and UPLC–ESI–QqQLIT–MS/MS. 2.1. Plant material and chemicals. 2.2. Extraction and sample preparation. 2.3. Preparation of Standard solution. 2.4. HPLC-ESI-QTOF-MS conditions. 2.5. UPLC-ESI-QqQLIT-MS/MS conditions. 2.6. Principal component analysis. 2.7. Optimization of UPLC conditions. 2.8. Optimization of MS/MS conditions. 2.7. Analytical Method Validation. 2.8. Optimization of MS/MS conditions. 2.9. Analytical Method Validation. 2.10. Qualittive Analysis of Cassia Species Samples. 2.11. Quantitative Analysis of Cassia Species Samples. 2.12. Principal Component Analysis to study chemical variations. 3. In-vitro Anti-Proliferative Screening in Selected Cassia Species. 3.1. Plant material. 3.2. Extraction and sample preparation. 3.3. Cell lines and anti-proliferative assay. 3.4. In-vitro anti-proliferative activity evaluation. 4. Bone regeneration effect of Cassia occidentalis Linn. extract and its isolated compounds. 4.1. Bone Healeing Property of Cassia occidentalis. 4.2. Osteoporosis and Arthritis. 4.3. The effects of CO extract fraction and formulation. 4.4. Effects of compounds derived from CO extract. 4. Conclusion.