Phytonutrients in the Treatment of Breast Cancer Molecular Aspects and Therapeutic Potential

1. Phytonutrients as a Therapeutic Modality: An Overview
Marwa A.A. Fayed, Muhammad Ajmal Shah, Waqar Aman, Uzma Saleem, Azhar Rasul, Syamsudin Abdillah, Peni Indrayudha and Agustina L. N. Aminin, Shahid Rasool, and Muhammad Yasir Ali

2. Breast Cancer Pathophysiology
Amira Yasmine Benmelouka, Muhammad Ajmal Shah, Yusra Talal Alnasser, Uzma Saleem, Avez Sharipov, Andi Hermansyah, Syamsudin Abdillah, Nazir Ahmad, and Kaisun Nesa Lesa

3. Breast Cancer Treatment: Limitations and Challenges
Rida Siddique, Zulfia Hussain, Uzma Saleem, Muhammad Qasim, Syamsudin Abdillah, Nazir Ahmad, Kaisun Nesa Lesa, Anthony Rios Marin, and Muhammad Ajmal Shah

4. Therapeutic Effects of Flavonoids in Breast Cancer
Rida Siddique, Faqir Muhammad, Uzma Saleem, Muhammad Qasim, Aqel Albutti, Samia Al-Shouli, Nazir Ahmad, Kaisun Nesa Lesa, and Muhammad Ajmal Shah

5. Therapeutic Role of Tannins in Breast Cancer
Muhammad Ibrar, Abdullah, Yaseen Hussain, Shah Zeb Khan, Fatima Saad Alaryani, Moneerah J. Alqahtani, and Muhammad Ajmal Shah

6. Therapeutic Role of Glycosides in Breast Cancer
Akbar Ali, Taseer Ahmad, Muhammad Ibrahim, Muhammad Ajmal Shah, Hina Anwar, Maira Ahmad, and Abdul Jabbar Shah

7. Therapeutic Effects of Alkaloids in Breast Cancer
Shahid Rasool, Muhammad Ajmal Shah, Adnan Amin, and Sadia Chaman

8. Therapeutic Effects of Terpenoids in Breast Cancer
Satya Prakash Singh, Anup Kumar Sirbaiya, Md. Habibur Rahman, Maria Silvana Alves, Chutha Takahashi Yupanqui, Putri Amelia, Ahmad Najib, and Muhammad Ajmal Shah

9. Protective Effects of Stilbenes on Breast Cancer
Mahendran Sekar and Amrita Muralikrishnan

10. Therapeutic Effects of Steroidal Compounds and Fatty Acids in Breast Cancer
Sadia Noor, Muhammad Ajmal Shah, Abdullah R. Alanzi, and Moneerah J. Alqahtani

11. Effect of Plant Derived Oils in Breast cancer
Faiza Waseem, Ali Sharif, Bushra Akhtar, Humaira Majeed Khan, Atif Ali Khan Khalil, Tanveer Khan, and Ayesha Tanveer

12. Genetic Effect of Phytonutrients in Breast cancer
Chenmala Karthika, Raman Sureshkumar, Fahad T. Alsulami,  Uswatun Khasanah, Md.,  Habibur Rahman, Abdullah R. Alanzi, Dikhnah Alshehri, and Muhammad Ajmal Shah

13. Therapeutic Role of Coumarins in Breast Cancer 

14. Therapeutic Effect of Plant-peptides in Breast Cancer
Yusuf Hussain, Waseem Raza, Jyoti Singh, Suaib Luqman, and Abha Meena 

15. Effects of Phytomedicines on Multi-Drug-Resistance in Breast Cancer
Hitesh Chopra, Rokeya Akter, and Tanima Bhattachary

16. Combining Effects of Phytomedicines with Synthetic Medicine in Breast Cancer; Interactions of Phytonutrients with Chemotherapeutic Agents
Tasahil Salih Albishi

17. Use of Bioinformatics Tools for the Discovery of Phytomedicines in Breast Cancer
Uzair Ahmed, Muhammad Qasim, Usman Ali Ashfaq, Mahmood-ur-Rahman, Muhammad Tariq, and Muhammad Shareef Masoud

18. Uses of Nanotechnologies of Phytonutrients in Breast Cancer
Faizullah Khan, Waseem ul Islam, Hanif Khan, Muhammad Waqas, Waqas Alam, Ahmed Zeb, and Haroon Khan

19. Microencapsulation of Phytonutrients in Breast Cancer
Muhammad Yasir Ali, Shahid Shah, Ghulam Abbas, Muhammad Ajmal Shah, Imran Tariq, and Muhammad Akhtar

20. Functional Foods Containing Phytonutrients in Breast Cancer
Esra Küpeli Akkol and Eduardo Sobarzo-Sánchez

21. Current Approaches to Prevent and Treat Breast Cancer Using Phytonutrients
Esra Küpeli Akkol, Methiye Mancak, and Gizem Türkcanoğlu

22. Challenges and Opportunities in Search of Phytonutrients in Breast Cancer
Mulazim Hussain Asim, Ifrah Arif, Shumaila Arshad, Muhammad Yasir Ali, and Alamgeer

23. Phytonutrients: Clinical Implications in Breast Cancer Prevention and Treatment
Arif Ali, Mac Dionys Rodrigues da Costa, Emanuel Paula Magalhães, and Alice Maria Costa Martins

24. Phytonutrients in the Treatment Of Breast Cancer: Focuses on Molecular Aspects
Faizullah Khan, Waseem ul Islam, Waqas Alam, Hanif Khan, Muhammad Waqas, and Haroon Khan

Biography

Dr. Haroon Khan (Fellow Royal Society of Chemistry; Member European Association for Cancer Research) is a Professor at the Department of Pharmacy, Abdul Wali Khan University Mardan. Dr. Khan has got PhD degree from University of Peshawar in Pharmaceutical Sciences.  He has more than twenty-three years’ experience in pharmacy teaching, research and professional expertise in various fields of pharmaceutical sciences. His research focus is phytomedicines/pharmacology. In this connection, he has already published 509 articles including Research, Reviews and Editorials in various national and international reputable journals. Prof. Khan is the editorial board member of a number of journals including Associate Editor in Phytomedicine and Frontiers in Nutrition, consulting editor of Pharmacological Research, Section Editor of Current Neuropharmacology, Current Molecular Pharmacology. The scientific contributions of Dr. Khan have been acknowledged by Pakistan Council for Science and Pakistan Council for Science and Technology (PCST), and awarded Research Productivity awards four times for the years 2011-2014. Dr. Khan is Clarivate Analytics Highly Cited Researchers. This clearly reflects the outstanding research potential of Dr. Khan acknowledged globally.

Dr. Muhammad Ajmal Shah is a registered pharmacist and an academic researcher. He obtained his PharmD and MPhil in Pharmacognosy degrees from Federal Urdu University, Karachi, Pakistan. He obtained his PhD in Pharmaceutical Sciences from Prince of Songkla University, Hat-Yai, Thailand by securing Thailand Education Hub for ASEAN Countries PhD Scholarship Award (TEH-AC 2014-17). He has published more than 100 scientific articles in well reputed international journals, edited one book with Elsevier and has authored over 60 chapters in different books published by Elsevier, Springer and other well recognized publishers. He has also been listed in Top 2% global research scientist’s category for the year 2024 as analysed and published by Stanford University, UK. He is a reviewer and an editorial board member of various reputed international journals. Dr. Shah is an active member of the American Society of Pharmacognosy, Phytochemical Society of Europe, American Society of Microbiology, and GA Society for Medicinal Plant and Natural Product Research Germany. Previously, he has worked as an assistant professor and head of department at the Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Pakistan and currently he is working as an Assistant Professor at Department of Pharmacy, Hazara University, Mansehra, Pakistan. He is also an adjunct professor at Department of Pharmacy, Diponegoro University, Indonesia, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Indonesia and Faculty of Pharmacy, Pancasila University Jakarta, Indonesia. His primary research interests include green extraction and enrichment of bioactive compounds, their isolation, and pharmacological evaluation in metabolic and aging-associated diseases.

Dr. Tarun Belwal is currently working at 7CNP, USA. Before this, Dr. Belwal worked at Texas A&M University, Texas, USA, the Department of Drug Science and Technology, University of Turin, Italy, and at the College of Biosystems Engineering and Food Science, Zhejiang University, China.

During his Ph.D., Dr. Belwal worked at G.B. Pant National Institute of Himalayan Environment (NIHE), Almora, Uttarakhand, India, on the utilization of natural products as nutraceutical agents and examined their functional activities, development of the plant in vitro cell culture, and advanced extraction techniques, for which he has awarded the prestigious ‘Governor award for Best Research’, by Uttarakhand Government, consequently for two years. He has completed a project as Principle Investigator (2018-20), funded by CPDSF, China. His excellent research credentials reflect over >100 peer-reviewed scientific publications, 15 book chapters, and 6 edited books with over more than 9000 citations. Dr. Belwal has guided several PhDs, postgraduates, and undergraduate students and jointly share the research outcomes. He also collaborated with several leading global researchers, which lead to fruitful collaborative outcomes.

PROF. DR. EDUARDO SOBARZO-SÁNCHEZ
Medicinal and Bioinorganic Chemistry Research Group
Grupo de Investigación “Química Médica y Bio-inorgánica” (QMEDBIN)
Instituto de Investigación y Doctorados
Facultad de Medicina y Ciencias de la Salud
Universidad Central de Chile CHILE

Full professor and researcher at the Instituto de Investigación y Doctorados, Facultad de Medicina y Ciencias de la Salud at the Universidad Central de Chile (UCEN, Chile). He was professor and researcher at the University of Chile (Chile) and University of Santiago de Compostela (USC, Spain), wherein he continues as an associate researcher at the Faculty of Pharmacy (USC) in the field of Natural Products-Medicinal Chemistry against CNS diseases and experimental studies about drug delivery systems.

From these research lines, there have been generated more than 170 scientific articles of high impact index in the field of the Chemistry, Pharmacy and Nanotechnology compiled in several journals. On the base of the excellent experimental results, and of direct application in the scope of the health, such results have been protected in more than 9 (European) protection patents and PCT (Patent Cooperation Treaty) that cover the scope of the applied nanomedicine in neuro-degenerative and parasitic diseases. At the present time, he is International Referee of Research Projects in the fields of Biomedicine, in Argentina and Chile (FONCYT and FONDECYT, respectively), and Spain for the National Agency of Evaluation and Prospective (ANEP).

He is Editor / Editorial Board member of the following journals; Molecules, International Journal of Nanomedicine, Journal of Nanomedicine and Nanotechnology, Archives of Natural Biological Research, Frontiers in Pharmacology, Mini-Reviews in Medicinal Chemistry, Current Medicinal Chemistry, Oxidative Medicine and Cellular Longevity and Current Topics in Medicinal Chemistry.

Inside the research activities carried out, two main research lines can be described; 1) Synthesis of compounds from natural sources or synthetic ways with pharmacological activity (neuro-degenerative dysfunctions and behavioral disorders as Parkinson’s and Alzheimer’s diseases and depression-anxiety, respectively), and parasitic diseases (Malaria, Leishmania), and; 2) Synthesis of supramolecular system derived from natural/synthetic polymers for controlled release of drugs.