During the past decade, a significant amount of research has been conducted on phytopharmaceuticals. Today, a growing body of evidence demonstrates the efficacy of a wide variety of natural products and affirms their potential in the treatment of cancer.
Phytopharmaceuticals in Cancer Chemoprevention focuses on the role of natural supplements in cancer prevention and therapy. The first section covers cancer epidemiology, as well as cancer statistics, current therapies, and potential toxicities involved with existing cancer drugs. The second section begins by discussing the pathophysiology of cancer including mechanistic and molecular aspects of cancer biology, and then explains the etiology of breast cancer, lung cancer, prostate cancer, tobacco and cancer, and gastrointestinal tract cancers, and concludes with the various risk factors related to obesity, exercise and aging. The third section covers phytopharmaceuticals and focuses on cancer health risk factors and the protective abilities of various natural products. The final section features commentary on cancer susceptibility and the value of natural remedies for healthy living.
With contributions from a diverse panel of renowned scientists and cancer biologists, this book covers a broad spectrum of phytopharmaceuticals in relation to their prospective roles in the future of cancer prevention and treatment. It is a valuable resource for nutrition scientists, oncologists, and dietitians in their efforts to conquer the challenge of cancer.
Table of Contents
Section 1. Introduction. Epidemiology of Cancer: An Overview with a Special Emphasis on Cancer Statistics 2003. Section 2. Pathophysiology of Cancer. Role of DNA Methylation in Cancer and Chemotherapy. Metals, Metalloids and Cancer. Molecular Mechanisms of Asbestos and Silica-induced Lung Cancer. Free Radicals, Environmental Radiation, and Cancer. Involvement of Receptor Tyrosine Kinases in Lung Cancer: Clinical Importance. Smokeless Tobacco, Oxidative Stress, and Cancer. The Regulatory Roles of Estrogen in Carcinogenesis: An Overview. NSAIDS and Colorectal Cancer. Current Perspectives in Gastric Adenocarcinoma. Adenocarcinoma of the Esophagus. Helicobacter pylori and Gastric Cancer. Free Radicals, Oxidative Stress and Cancer. Biotransformation and Mechanism of Action of Xenobiotics: What Lessons from the Past Forty Years?. Obesity and Cancer. Hemangioendothelioma as a Model to Study the Anti-Angiogenic Effects of Dietary Chemopreventive Agents in vivo. Modulation of Late Adverse Effects of Curative Radiation Therapy for Cancer.
Section 3. Phytopharmaceuticals and Chemoprevention
Development of Selected Phytochemicals for Cancer Chemoprevention, Vernon Steele
Phytochemicals as Potential Cancer Chemopreventive Agents, Rajendra G. Mehta and John M. Pezzuto
History of Natural Supplements in Cancer Therapy and Prevention, Gottumukkala V. Subbaraju and Golakoti Trimurtulu
Vitamin C, Vitamin E and b-Carotene in Cancer Chemoprevention, Balz Frei and Jane Higdon
Role of Polyphenols, Flavonoids and Oligomeric Proanthocyanidins in Cancer Chemoprevention, Sidhartha Ray and Debasis Bagchi
Curcumin Derived from Turmeric (Curcuma longa): A Spice for All Seasons, Bharat B. Aggarwal, Anushree Kumar, Manoj S. Aggarwal, and Shishir Shishodia
Tea in Chemoprevention of Cancer, Vaqar Mustafa Adhami, Moammir Hasan Aziz, Nihal Ahmad, and Hasan Mukhtar
Phytoestrogens in Cancer Prevention: Characterization and Beneficial Effects of a New Flavanone, Kurarinone
Debasis Bagchi, Harry G. Preuss