1st Edition
Plant-Derived Anticancer Drugs in the OMICS Era Biosynthesis, Functions, and Applications
The current anti-cancer synthetic medicines are deemed inefficient and unsafe, state the editors of this new book. Plant-based lead molecules, however, such as taxol, camptothecin, podophyllotoxins, vinblastine, vincristine, homoharringtonine, and numerous other anticancer compounds from nature’s arsenal, are potentially safe and can be powerful alternatives that effectively fight against cancer.
The volume looks at a variety of medicinal plants and approaches that have shown beneficial results against cancer. Topics in the book include Unani approaches of anticancer plants, genetic engineering and CRISPR/CAS-mediated editing to enhance a plant’s anticancer potential, computational approaches used in anticancer plants, and more. The volume also examines the metabolomics of plants that give them anti-cancer properties.
1. Evaluation of Extracts from Curcumalonga and Zingiber officinale as Growth Inhibitors of HeLa and HuH-7 Cell Lines
Jordi Orlando González-Osuna, Alberto Barbabosa-Pliego, Esvieta Tenorio-Borroto, Salvador Chavez-Salinas, María Uxua Alonso-Fresan, Jose Maria Eloy Contreras-Ortiz, Juan Carlos Vazquez-Chagoyan, Luis German Lopez-Valdez, Cesar Reyes, Braulio Edgar Herrera-Cabrera, Fabiola Zaragoza-Martinez, Gonzalo Guillermo Lucho-Constantino, and Hebert Jair Barrales-Cureno
2. Role of Herbal Medicines in Liver Cancer
S. Nizamudeen, Yumna Baqi, and Sarafraz Arqum Shah
3. Unani Approaches of Anticancer Plants Against Cancer
Sana Nafees and Huda Nafees
4. Exploration of Anticancer Medicinal Plants of Northern Hemisphere
Younis Ahmad Hajam, Aishwarya Sharma, Javid Ahmad Malik, Rajesh Kumar, and Raksha Rani
5. Genetic Engineering of Plants for Enhanced Anticancer Potential
Bushra Hafeez Kiani
6. Genetic Engineering of Plants of Enhancing Secondary Metabolites with Anti-Cancerous Properties
Nilanjana Das and Aryadeep Roychoudhury
7. Genomics of Plants with Anticancer Properties: Breaking New Ground in Cancer Therapy
Mubasshira Mohammed Mazhar Ul Haque, Lekha Bhagtaney, and Priya Sundarrajan
8. Metabolomics of Anti-Cancer Plants
S. Ruth Assumi, Khanmi Kasomva, and Pooja Bhadrecha
9. Computational Approaches Used in Anticancer Plants
Fulden Ulucan-Karnak, Zeynep Yilmaz-Sercinoglu, Onur Sercinoglu, and Ahmad Ali
10. CRISPR/CAS-Mediated Editing of Anticancer Plants
Muhammad Shan, Zulqurnain Khan, and Muhammad Arslan Akhtar
11. Zinc Finger Nuclease (ZFNs) and Transcription Activator-Like Effector Nucleases (TALENs): Based Genome Editing in Enhancement of Anticancer Activity of Plants
Pooja Saraswat, Ambika Chaturvedi, and Rajiv Ranjan
Biography
Deepu Pandita is a Senior Lecturer in the Government Department of School Education, Jammu, India. She has more than 19 years of teaching experience. She has published editorials, book chapters, reviews, and research articles in journals of national and international repute and also acts as a reviewer, associate editor, and editor of several international journals. She has presented her research at professional conferences and has received awards for her work.
Anu Pandita is a Dietician at Vatsalya Clinic, Krishna Nagar, New Delhi, India. Previously she worked as a lecturer at Bee Enn College of Nursing, Talab Tillo, Jammu, India, and as a Dietician at Ahinsa Dham Bhagwan Mahavir Charitable Health Centre, New Delhi, India. She conducted a case study at the Pediatric Gastroenterology Ward at Nehru Hospital, PGI, Chandigarh, India, on a patient suffering from chronic liver disease. She has published books, book chapters, and research articles in journals of national and international repute and has also presented her research at national and international conferences.
Titles of related interest from Deepu Pandita and Anu Pandita:
• Antidiabetic Plants for Drug Discovery: Pharmacology, Secondary Metabolite Profiling,
and Ingredients with Insulin Mimetic Activity
• Plant Transposable Elements: Biology and Biotechnology
• CRISPR/Cas-Mediated Genome Editing in Plants
• Antidiabetic Potential of Plants in the Era of Omics
• Potent Anticancer Medicinal Plants: Secondary Metabolite Profiling, Active Ingredients,
and Pharmacological Outcomes
