1st Edition

Polymeric Biomaterials Medicinal and Pharmaceutical Applications, Volume 2

Edited By Severian Dumitriu, Valentin Popa Copyright 2013
    790 Pages 244 B/W Illustrations
    by CRC Press

    790 Pages 244 B/W Illustrations
    by CRC Press

    Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set.

    This volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, contains 28 authoritative chapters written by experts from around the world. Contributors cover the following topics:

    • Processing polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for use in various applications in the medical and pharmaceutical arenas
    • Use of biomaterials to address medical issues such as pulmonary disease, cancer, heart disease, tissue damage, and bone disease
    • Applications including a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering

    Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials and the most up-to-date applications of biomaterials in medicine.

    Antithrombin–Heparin Complexes
    Leslie R. Berry and Anthony K.C. Chan

    Glucose-Sensitive Hydrogels
    Seong Hoon Jeong, Kyung T. Oh, and Kinam Park

    Advances in Polymeric and Lipid-Core Micelles as Drug Delivery Systems
    Tiziana Musacchio and Vladimir P. Torchilin

    Modular Biomimetic Drug Delivery Systems
    Carmen Alvarez-Lorenzo, Fernando Yañez- Gomez, and Angel Concheiro

    Polymeric Nanoparticles for Drug Delivery
    Karine Andrieux, Julien Nicolas, Laurence Moine, and Gillian Barratt

    Drug Carrier Systems for Anticancer Agents
    Hiroyuki Koide, Tomohiro Asai, Kosuke Shimizu, and Naoto Oku

    Application of Polymer Drugs to Medical Devices and Preparative Medicine
    M.R. Aguilar, L. García-Fernández, M.L. López-Donaire, F. Parra, L. Rojo, G. Rodríguez, M.M. Fernández, and J. San Román

    Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy
    Brent D. Weinberg and Jinming Gao

    Biological Stimulus-Responsive Hydrogels
    A.K. Bajpai, Sanjana Kankane, Raje Chouhan, and Shilpi Goswami

    Polymeric Materials for Surface Modification of Living Cells
    Yuji Teramura, Hao Chen, Naohiro Takemoto, Kengo Sakurai, and Hiroo Iwata

    Biomedical Applications of Shape Memory Polymers and Their Nanocomposites
    I. Sedat Gunes and Sadhan C. Jana

    Bioadhesive Drug Delivery Systems
    Ryan F. Donnelly and A. David Woolfson

    Nanomedicines Coming of Age
    Radoslav Savic, Jinzi Zheng, Christine Allen, and Dusica Maysinger

    Polymers for Myocardial Tissue Engineering
    J.A. Roether, H. Jawad, R. Rai, N.N. Ali, S.E. Hardling, and A.R. Boccaccini

    Acellular Tubular Grafts Constructed from Natural Materials in Vascular Tissue Engineering
    M.J.W. Koens, A.G. Krasznai, J.A. van der Vliet, T. Hendriks, R.G. Wismans, K.A. Faraj, W.F. Daamen, and T.H. van Kuppevelt

    pH-Responsive Polymers for Delivery of Nucleic Acid Therapeutics
    Yu Nie and Ernst Wagner

    Adhesive Biomaterials for Tissue Repair and Reconstruction
    Sujata K. Bhatia

    Polymeric Interactions with Drugs and Excipients
    James C. DiNunzio and James W. McGinity

    Manufacturing Multifunctional Scaffolds for Tissue Engineering
    Vincenzo Guarino, Antonio Gloria, Roberto De Santis, and Luigi Ambrosio

    Virus-Based Nanoparticles as Drug Delivery Systems
    Eva Roblegg and Andreas Zimmer

    Polymeric Biomaterials in Pulmonary Drug Delivery
    Nicole A. Beinborn and Robert O. Williams III

    Polymeric Gene Delivery Carriers for Pulmonary Diseases
    Xiang Gao, Regis R. Vollmer, and Song Li

    Biomedical Application of Membranes in Bioartificial Organs and Tissue Engineering
    Thomas Groth, Xiao-Jun Huang, and Zhi-Kang Xu

    Controlled Release Systems for Bone Regeneration
    Hossein Hosseinkhani

    Controlled Release Systems Targeting Angiogenesis
    Stéphanie Deshayes, Karine Gionnet, Victor Maurizot, and Gérard Déléris

    Bioceramics for Development of Bioartificial Liver
    Tomokazu Matsuura and Mamoru Aizawa

    Materials Biofunctionalization for Tissue Regeneration
    Laura Cipolla, Laura Russo, Nasrin Shaikh, and Francesco Nicotra

    Polymers-Based Devices for Dermal and Transdermal Delivery
    Donatella Paolino, Margherita Vono, and Felisa Cilurzo


    Severian Dumitriu (deceased) was a research professor in the Department of Chemical Engineering at the University of Sherbrooke, Quebec, Canada. He edited several books, including Polymeric Biomaterials, Second Edition, Polysaccharides in Medicinal Applications, and Polysaccharides: Structural Diversity and Functional Versatility. He also authored or coauthored more than 190 professional papers and book chapters in the fields of polymer and cellulose chemistry, polyfunctional initiators, and bioactive polymers and held 15 international patents. Professor Dumitriu received his BSc (1959) and MS (1961) in chemical engineering and his Ph.D. (1971) in macromolecular chemistry from the Polytechnic Institute of Jassy, Romania.

    Valentin I. Popa earned his BSc and MSc in chemical engineering (1969) and Ph.D. in the field of polysaccharide chemistry (1976) from Polytechnic Institute of Iasi, Romania. He was awarded the Romanian Academy Prize for his contributions in the field of seaweed chemistry (1976). He has published more than 500 papers in the following fields: wood chemistry and biotechnology, biomass complex processing, biosynthesis and biodegradation of natural compounds, allelochemicals, bioadhesives, and bioremediation. Dr Popa is also the author or coauthor of 37 books or book chapters. He holds six patents and has been involved in many Romanian and European research projects as scientific manager. He is also a professor of wood chemistry and biotechnology at "Gheorghe Asachi" Technical University of Iasi, and editor-in-chief of Cellulose Chemistry and Technology.

    "This third edition set is a versatile and comprehensive book, presenting new and substantially revised topics, and combining the basic fundamentals of the field of biomaterials with the industrial applications. Thus, the book is a very useful tool for scientists, engineers, pharmacists and other experts from different disciplines, as well as for teachers, graduate and undergraduate students interested in this area."
    —Diana Ciolacu, Cellulose Chem. Technol., 47 (5-6), 487-494 (2013)