1st Edition

Polymeric Drug Delivery Systems

Edited By Glen S. Kwon Copyright 2005
    666 Pages 173 B/W Illustrations
    by CRC Press

    Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

    Preface

    Contributors

    N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates

    Ruth Duncan

    Background

    HPMA Copolymer Conjugates—An Historical Perspective

    Synthesis and Characterization of HPMA Copolymer Conjugates

    Biological Rationale for Design and Potential Applications

    Clinical Status of HPMA Copolymer Conjugates

    Other Applications

    Related Technologies

    Future Prospects

    Functional PEG for Drug Delivery

    Motoi Oishi, Yukio Nagasaki, and Kazunori Kataoka

    Introduction

    Synthesis of Heterotelechelic Poly(ethylene Glycol)s

    Synthesis of an End-Functionalized Block Copolymer Possessing a PEG Segment

    Bioconjugation Using Heterotelechelic PEG

    Functionalized Polymeric Micelles by a Self-Assemblingof End-Functionalized PEG Block Copolymers

    Conclusion

    pH-Sensitive Polymers for Drug Delivery

    Kun Na and You Han Bae

    Introduction

    pH Variation in the Body

    pH-Sensitive Polymers

    Oral Delivery

    Parenteral Drug Carriers

    Conclusion

    Hydrogels for Oral Administration

    Seong Hoon Jeong, Yourong Fu, and Kinam Park

    Introduction

    Application of Hydrogels in Oral Drug

    Delivery

    Hydrogels for Specific Applications

    Hydrogels for the Controlled Release of Proteins

    Wim E. Hennink, Cornelus F. van Nostrum, Daan J. A. Crommelin, and Jeroen M. Bezemer

    Introduction

    Hydrogels: General Features

    Dextran Hydrogels as Protein-Releasing Matrices

    Amphiphilic Poly(ether Ester) Multiblock Copolymers as Protein-Releasing Matrices

    The Stability of Hydrogel-Associated Pharmaceutical Proteins

    Concluding Remarks

    Thermosensitive Biodegradable Hydrogels for the Delivery of Therapeutic Agents

    Young Min Kwon and Sung Wan Kim

    Introduction

    Poly(N-Isopropylacrylamide) and Its Copolymers

    PEO-PPO-PEO Triblock Copolymers

    Thermosensitive and Biodegradable Polymer Hydrogels

    Biodegradable Microspheres Based on the Thermosensitive Property of PLGA-PEG-PLGA

    Conclusions

    Hydrogels: Stimuli-Sensitive Hydrogels

    Akihiko Kikuchi and Teruo Okano

    Introduction

    Stimuli-Responsive Hydrogels and Their Applications in Drug Delivery Systems

    Conclusions

    Treatment of Malignant Brain Tumors with Controlled-Release Local-Delivery Polymers . .

    Alex A. Khalessi, Paul P. Wang, Robert S. Langer, and Henry Brem

    Introduction

    Drug Delivery Considerations in the CNS

    Biocompatible Polymer Development: An Historical Perspective

    Clinical Applications of Polyanhydride Polymers for Intracranial Drug Delivery

    Future Directions

    Conclusions

    Improving the Stability of PLGA-Encapsulated Proteins

    Steven P. Schwendeman and Jichao Kang

    Overview and Historical Perspective

    Evidence of Protein Instability

    What Is the Instability Pathway?

    Examples of Stabilizing PLGA-Encapsulated Proteins

    Concluding Remarks

    Recombinant Polymers for Drug Delivery

    Zaki Megeed and Hamidreza Ghandehari

    Introduction

    Synthesis and Characterization

    Drug Delivery Applications

    Gene Delivery Applications

    Tissue Repair Applications

    Biocompatibility and Biodegradation

    Conclusions

    Polymeric Nanoparticle Delivery of Cancer Vaccines

    John Samuel and Glen S. Kwon

    Introduction

    Cancer Vaccines: Promise and Problems

    Critical Issues in Cancer Vaccine Delivery

    Cancer Vaccine Delivery: Living vs. Non-Living Systems

    PLGA-Based Pharmaceutical Delivery Systems

    ‘‘Pathogen Mimicking’’ Nanoparticles for Cancer Vaccines

    Concluding Remarks

    Polymer Assemblies: Intelligent Block Copolymer Micelles for the Programmed Delivery of Drugs and Genes

    Younsoo Bae and Kazunori Kataoka

    Introduction

    Rationale for Delivery System Using Polymer Assemblies

    Block Copolymer Micelles for Drug Delivery

    Block Copolymer Micelles for the Delivery of Genes and Charged Materials

    Programmed Delivery Using Block Copolymer Micelles

    Future Prospects of Block Copolymer Micelles

    Polymeric Micelles for the Targeting of Hydrophobic Drugs

    Masayuki Yokoyama

    Polymeric Micelles for Drug Carriers

    The History of Polymeric Micelle Drug Carriers

    The Molecular Design of Polymeric Micelle Drug Carrier Systems

    Examples of Drug Targeting with Polymeric Micelle Carriers

    Pluronic_ Block Copolymers for Drug and Gene Delivery

    Alexander V. Kabanov and Jian Zhu

    Introduction

    Pluronic Structure and Synthesis

    Self-Assembly of Pluronic Block Copolymers

    Pluronic_ Formulations for Treatment of Drug-Resistant Tumors

    Pluronic Effects on Brain and Oral Bioavailability of Drugs

    Optimization of Pluronic Composition for PGP Inhibition

    Pluronic Block Copolymers for Gene Therapy

    Graft Copolymers for Therapeutic Gene Delivery

    Anurag Maheshwari, James W. Yockman, and Sung Wan Kim

    Non-viral gene Therapy

    Nomenclature of Graft Copolymers

    Cationic Graft Copolymers

    Biodegradable and Targetted Polymeric Gene Carriers

    Index

    Biography

    Glen S. Kwon