Polymorphism in Pharmaceutical Solids: 2nd Edition (Hardback) book cover

Polymorphism in Pharmaceutical Solids

2nd Edition

Edited by Harry G. Brittain

CRC Press

656 pages | 200 B/W Illus.

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Hardback: 9781420073218
pub: 2009-07-27
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pub: 2018-11-12
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Description

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.

Topics include:

  • Computational methodologies
  • High-throughput screening methods
  • Pharmaceutical cocrystals
  • Thermally-induced and solution-mediated phase transformations
  • Amorphous solids
  • Crystallography preparation and characterization
  • The amorphous state

Table of Contents

THERMODYNAMIC AND THEORETICAL ISSUES

Theory and Principles of Polymorphic Systems, Harry G. Brittain

Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems, Harry G. Brittain

Computational Methodologies: Toward Crystal Structure and Polymorph Prediction, Sarah (Sally) L. Price

PREPARATIVE METHODS FOR POLYMORPHS AND SOLVATOMORPHS

Classical Methods of Preparation of Polymorphs and Alternative Solid Forms, Peter W. Cains

Approaches to High-Throughput Physical Form Screening and Discovery, Alastair J. Florence

STRUCTURAL PROPERTIES OF POLYMORPHS AND SOLVATOMORPHS

Structural Aspects of Polymorphism, Harry G. Brittain, Stephen R. Byrn, and Eunhee Lee

Structural Aspects of Solvatomorphic Systems, Harry G. Brittain, Kenneth R. Morris, and Stephan X. M. Boerrigter

Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds, Kapildev K. Arora and Michael J. Zaworotko

CHARACTERIZATION METHODS FOR POLYMORPHS AND SOLVATOMORPHS

Thermoanalytical and Crystallographic Methods, Sisir Bhattacharya, Harry G. Brittain, and Raj Suryanarayanan

Vibrational Spectroscopy, Harry G. Brittain

Solid-State Nuclear Magnetic Resonance Spectroscopy, Patrick A. Tishmack

Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate, Harry G. Brittain, David J. R. Grant, and Paul B. Myrdal

INTERCONVERSION OF POLYMORPHS AND SOLVATOMORPHS

Solid-State Phase Transformations, Harry G. Brittain

Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials, Peter L. D. Wildfong

SPECIAL TOPICS RELATED TO POLYMORPHISM AND SOLVATOMORPHISM

Structural Aspects of Molecular Dissymmetry, Harry G. Brittain

Amorphous Solids, Lynne S. Taylor and Sheri L. Shamblin

Index

About the Series

Drugs and the Pharmaceutical Sciences

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Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology