1st Edition

Practical Aspects of Trapped Ion Mass Spectrometry, Volume V Applications of Ion Trapping Devices

Edited By Raymond E. March, John F.J Todd Copyright 2010
    566 Pages 237 B/W Illustrations
    by CRC Press

    Widely used in medical research, pharmaceutical and fine chemicals industries, biological and physical sciences, and security and environmental agencies, mass spectrometry techniques are continually under development. In Practical Aspects of Trapped Ion Mass Spectrometry: Volume V, Applications of Ion Trapping Devices, an international panel of authors presents a world-wide view of the practical aspects of recent progress using trapped ion devices.

    In contrast to previous texts, which have concentrated generally on a single or limited range of ion trapping techniques, a key feature of this compilation of contributions is its coverage of all the ion trapping techniques currently in use. Spanning sixteen chapters, the text examines:

    • Ion/neutral and ion/ion reactions
    • Structural characterization of proteins and peptides using quadrupole ion trap mass spectrometry, Fourier transform – ion cyclotron resonance (FT-ICR) mass spectrometry, and traveling wave ion mobility mass spectrometry
    • Ion spectroscopy and electron diffraction
    • Conformational analysis of protein isobaric charge states
    • Practical examples of trapped-ion technology that reflect the wide diversity of applications of trapped-ion devices

    This text is the first detailed account of the application of new and established mass spectrometric techniques utilizing trapped or confined ions for prolonged investigation and increased sensitivity. Each chapter contains complete references and utilizes a consistent format and writing style, with all terms, acronyms, procedures, and equations thoroughly explained. The strong editorial input to the diverse sections enables readers to readily appreciate the commonalities of topics ranging from theory of instrument operation to proteins, flavonoids, atomic clocks, and single ion mass spectrometry.

    Ion Reactions

    Ion/Ion Reactions in Electrodynamic Ion Traps, J. Liu and S. A. McLuckey

    Gas-Phase Hydrogen/Deuterium Exchange in Quadrupole Ion Traps, J. E. Chipuk and J. S. Brodbelt

    Methods for Multi-Stage Ion Processing Involving Ion/Ion Chemistry in a Quadrupole Linear Ion Trap, G. C. McAlister and J. J. Coon

    Ion Conformation and Structure

    Chemical Derivatization and Multistage Tandem Mass Spectrometry for Protein Structural Characterization, J. M. Froelich, Y. Lu, and G. E. Reid

    Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in the Analysis of Peptides and Proteins, H. J. Cooper

    MS/MS Analysis of Peptide-Polyphenols Supramolecular Assemblies: Wine Astringency Approached by ESI-IT-MS, B. Plet and J.-M. Schmitter

    Structure and Dynamics of Trapped Ions, J. H. Parks

    Applications of Traveling Wave Ion Mobility-Mass Spectrometry, K. Thalassinos and J. H. Scrivens

    Ion Spectroscopy

    The Spectroscopy of Ions Stored in Trapping Mass Spectrometers, M. W. Forbes, F. O. Talbot, and R. A. Jockusch

    Sympathetically-Cooled Single Ion Mass Spectrometry, P. F. Staanum, K. Højbjerre, and M. Drewsen

    Ion Trap: A Versatile Tool for the Atomic Clocks of the Future! F. Vedel

    Practical Applications

    Boundary-Activated Dissociations (BAD) in a Digital Ion Trap (DIT), F. L. Brancia, L. Raveane, A. Berton, and P. Traldi

    The Study of Ion/Molecule Reactions at Ambient Pressure with Ion Mobility Spectrometry and Ion Mobility/Mass Spectrometry, G. A. Eiceman and J. A. Stone

    The Role of Trapped Ion Mass Spectrometry for Imaging, T. J. Garrett and R. A. Yost

    Technology Progress and Application in GC/MS and GC/MS/MS, M. Wang and J. E. George III

    Remote Monitoring of Volatile Organic Compounds in Water by Membrane Inlet Mass Spectrometry, R. Pozzi, P. Bocchini, F. Pinelli, and G. C. Galletti



    Raymond E. March, PhD, DSc, D(hc), FCIC, is presently Professor Emeritus of Chemistry at Trent University in Peterborough, Ontario, Canada. John F.J. Todd, BSc, PhD, CChem, FRSC, CEng, FInstMC, is currently Emeritus Professor of Mass Spectroscopy at the University of Kent, Canterbury, UK.