Practical Aspects of Trapped Ion Mass Spectrometry, Volume V : Applications of Ion Trapping Devices book cover
1st Edition

Practical Aspects of Trapped Ion Mass Spectrometry, Volume V
Applications of Ion Trapping Devices

ISBN 9781420083736
Published November 11, 2009 by CRC Press
566 Pages 237 B/W Illustrations

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Book Description

Widely used in medical research, pharmaceutical and fine chemicals industries, biological and physical sciences, and security and environmental agencies, mass spectrometry techniques are continually under development. In Practical Aspects of Trapped Ion Mass Spectrometry: Volume V, Applications of Ion Trapping Devices, an international panel of authors presents a world-wide view of the practical aspects of recent progress using trapped ion devices.

In contrast to previous texts, which have concentrated generally on a single or limited range of ion trapping techniques, a key feature of this compilation of contributions is its coverage of all the ion trapping techniques currently in use. Spanning sixteen chapters, the text examines:

  • Ion/neutral and ion/ion reactions
  • Structural characterization of proteins and peptides using quadrupole ion trap mass spectrometry, Fourier transform – ion cyclotron resonance (FT-ICR) mass spectrometry, and traveling wave ion mobility mass spectrometry
  • Ion spectroscopy and electron diffraction
  • Conformational analysis of protein isobaric charge states
  • Practical examples of trapped-ion technology that reflect the wide diversity of applications of trapped-ion devices

This text is the first detailed account of the application of new and established mass spectrometric techniques utilizing trapped or confined ions for prolonged investigation and increased sensitivity. Each chapter contains complete references and utilizes a consistent format and writing style, with all terms, acronyms, procedures, and equations thoroughly explained. The strong editorial input to the diverse sections enables readers to readily appreciate the commonalities of topics ranging from theory of instrument operation to proteins, flavonoids, atomic clocks, and single ion mass spectrometry.

Table of Contents

Ion Reactions. Ion/Ion Reactions in Electrodynamic Ion Traps. Gas-Phase Hydrogen/Deuterium Exchange in Quadrupole Ion Traps. Methods for Multi-Stage Ion Processing Involving Ion/Ion Chemistry in a Quadrupole Linear Ion Trap. Ion Conformation and Structure. Chemical Derivatization and Multistage Tandem Mass Spectrometry for Protein Structural Characterization. Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in the Analysis of Peptides and Proteins. MS/MS Analysis of Peptide-Polyphenols Supramolecular Assemblies: Wine Astringency Approached by ESI-IT-MS. Structure and Dynamics of Trapped Ions. Applications of Traveling Wave Ion Mobility-Mass Spectrometry. Ion Spectroscopy. The Spectroscopy of Ions Stored in Trapping Mass Spectrometers. Sympathetically-Cooled Single Ion Mass Spectrometry. Ion Trap: A Versatile Tool for the Atomic Clocks of the Future! Practical Applications. Boundary-Activated Dissociations (BAD) in a Digital Ion Trap (DIT). The Study of Ion/Molecule Reactions at Ambient Pressure with Ion Mobility Spectrometry and Ion Mobility/Mass Spectrometry.The Role of Trapped Ion Mass Spectrometry for Imaging.Technology Progress and Application in GC/MS and GC/MS/MS. Remote Monitoring of Volatile Organic Compounds in Water by Membrane Inlet Mass Spectrometry. Index.

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Raymond E. March, PhD, DSc, D(hc), FCIC, is presently Professor Emeritus of Chemistry at Trent University in Peterborough, Ontario, Canada. John F.J. Todd, BSc, PhD, CChem, FRSC, CEng, FInstMC, is currently Emeritus Professor of Mass Spectroscopy at the University of Kent, Canterbury, UK.