4th Edition

Principles of Biochemical Toxicology

By John A. Timbrell Copyright 2009
    464 Pages 232 B/W Illustrations
    by CRC Press

    This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.

    Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching.

    New to the Fourth Edition:

    • reorganized sections that cover basic principles followed by sections on different types of toxicity
    • extensive use of examples throughout and numerous explanatory diagrams
    • new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more
    • questions with answers for each chapter for review and self-checking
    • expanded and updated chapter bibliographies

    An Introduction to Epigenetics

    Manel Esteller

    Epigenetics and Cancer: DNA Methylation

    Santiago Ropero and Manel Esteller

    Epigenetics and Cancer: Histone Modifications

    Mario F Fraga and Manel Esteller

    Epigenetic Drugs: DNA Demethylating Agents

    Ehab Atallah and Guillermo Garcia-Manero

    Epigenetic Drugs: Histone Deacetylase Inhibitors

    Melissa Peart and Ricky W Johnstone

    Sirtuins in Biology and Disease

    Alejandro Vaquero and Danny Reinberg

    MicroRNAs in Cell Biology and Diseases

    Muller Fabbri, Carlo M Croce, and George A Calin

    Chromatin Modifications by Polycomb Complexes

    Miguel Vidal

    Epigenetics and its Genetic Syndromes

    Richard J Gibbons

    Epigenetics and Immunity

    Esteban Ballestar and Bruce Richardson

    Etiology of Major Psychosis: Why Do We Need Epigenetics?

    Gabriel Oh and Arturas Petronis

    Epigenetics and Cardiovascular Disease

    Gertrud Lund and Silvio Zaina

    Plant Epigenetics

    Mónica Meijón, Luis Valledor, Jose Luis Rodríguez,

    Rodrigo Hasbún, Estrella Santamaría, Isabel Feito,

    Maria Jesús Cañal, Maria Berdasco, Mario F Fraga,

    and Roberto Rodríguez

    Epigenetics, Environment, and Evolution

    Douglas M Ruden, Parsa Rasouli, and Xiangyi Lu

    Epigenetics and Epigenomics

    José Ignacio Martín-Subero and Reiner Siebert









    An Introduction to Epigenetics. Epigenetics and Cancer: DNA Methylation. Epigenetics and Cancer: Histone Modifications. Epigenetic Drugs: DNA Demethylating Agents. Epigenetic Drugs: Histone Deacetylase Inhibitors. Sirtuins in Biology and Disease. MicroRNAs in Cell Biology and Diseases. Chromatin Modifications by Polycomb Complexes. Epigenetics and its Genetic Syndromes. Epigenetics and Immunity. Etiology of Major Psychosis: Why Do We Need Epigenetics?. Epigenetics and Cardiovascular Disease. Plant Epigenetics. Epigenetics, Environment, and Evolution Epigenetics and Epigenomics. Index.


    John A. Timbrell