1st Edition

Principles of Computational Genomics

By Paolo Provero Copyright 2025
212 Pages 83 Color Illustrations
by Chapman & Hall

212 Pages 83 Color Illustrations
by Chapman & Hall

212 Pages 83 Color Illustrations
by Chapman & Hall

The advent of high-throughput experimental assays, and in particular of next-generation sequencing, has revolutionized life sciences by enabling the generation of data at the scale of the whole genome. Extracting biologically useful or clinically actionable information from this data requires analytical methods quite different from the ones used to analyze low-throughput experimental results. The... Read more

Chapter 1 ■ Sequence alignment and phylogenetics

Chapter 2 ■ Transcriptomics, part I: class comparison

Chapter 3 ■ Transcriptomics, part II: class discovery and enrichment analysis

Chapter 4 ■ Transcriptomics, part III: single-cell RNA-sequencing

Chapter 5 ■ Transcriptional regulation

Chapter 6 ■ Variation and phenotype

Bibliography

Index

 

Biography

Paolo Provero obtained his PhD in Theoretical Physics in 1992. Since 2000, his research focuses on computational genomics, and in particular on the evolution and variation of gene expression and gene regulation. He is currently Full Professor of Molecular Biology at the University of Turin, Italy.