614 Pages 225 Color Illustrations
    by Garland Science

    614 Pages 225 Color Illustrations
    by Garland Science

    614 Pages 225 Color Illustrations
    by Garland Science

    This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces.  Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.

    Preface

    Contributors

    PART I. DEVELOPMENT AND STRUCTURE OF MUCOSAL TISSUE

    1. Overview of the mucosal immune system structure

    Reinhard Pabst and Per Brandtzaeg

    2. Phylogeny of the mucosal immune system

    Robert D. Miller and Irene Salinas

    3. Immunologic and functional differences among individual compartments of the mucosal immune system

    Hiroshi Kiyono, Kohtaro Fujihashi, and Jiri Mestecky

    4. Secreted effectors of the innate mucosal barrier

    Michael A. McGuckin, Andre J. Ouellette, and Gary D. Wu

    PART II. CELLULAR CONSTITUENTS OF MUCOSAL IMMUNE SYSTEMS AND THEIR FUNCTION IN MUCOSAL HOMEOSTASIS

    5. Immune function of epithelial cells

    Richard S. Blumberg, Wayne Lencer, Arthur Kaser, and Jerrold R. Turner

    6. Intraepithelial T cells: Specialized T cells at epithelial surfaces

    Hilde Cheroutre

    7. T lymphocyte populations within the lamina propria

    Thomas T. MacDonald and Antonio Di Sabatino

    8. Innate lymphoid cells

    Gerard Eberl and Nicholas Powell

    9. Role of regulatory T cells in mucosal immunity

    Kenya Honda and Shohei Hori

    10. Mucosal B cells and their function

    Jo Spencer, Edward N. Janoff, and Per Brandtzaeg

    11. Secretory immunoglobulins and their transport

    Charlotte S. Kaetzel, Jiri Mestecky, and Jenny M. Woof

    12. Role of dendritic cells in integrating immune responses to luminal antigens

    Brian L. Kelsall and Maria Rescigno

    13. Intestinal macrophages in defense of the mucosa

    Lesley E. Smythies and Phillip D. Smith

    14. Mucosal basophils, eosinophils, and mast cells

    Edda Fiebiger and Stephan C. Bischoff

    15. M cells and the follicle-associated epithelium

    Hiroshi Ohno, Marian Neutra, and Ifor R. Williams

    16. Lymphocyte trafficking from inductive sites to effector sites

    Valerie Verhasselt, William Agace, Oliver Pabst, and Andrew Stagg

    17. Mucosal tolerance

    Charles O. Elson and Oliver Pabst

    PART III. MICROBIAL COMMENSALISM

    18. Recognition of microbe-associated molecular patterns by pattern recognition receptors

    Elke Cario

    19. Commensal microbiota and its relationship to homeostasis and disease

    Jonathan Braun, Elaine Y. Hsiao, and Nicholas Powell

    PART IV. GENITOURINARY TRACT

    20. The immune system of the genitourinary tract

    David A. MacIntyre and Kenneth W. Beagley

    21. Mucosal immune responses to microbes in genital tract

    Akiko Iwasaki

    PART V. NOSE, AIRWAYS, ORAL CAVITY, AND EYES

    22. Nasopharyngeal and oral immune system

    Hiroshi Kiyono and Kohtaro Fujihashi

    23. Bronchus-associated lymphoid tissue and immune-mediated respiratory diseases

    Dale T. Umetsu and Bart Lambrecht

    24. Ocular surface as mucosal immune site

    Rachel R. Caspi and Anthony St. Leger

    PART VI. INFECTIOUS DISEASES OF MUCOSAL SURFACES

    25. Mucosal interactions with enteropathogenic bacteria

    Nadine Cerf-Bensussan, Pamela Schnupf, Valérie Gaboriau-Routhiau, and Philippe J. Sansonetti

    26. Helicobacter pylori infection

    Diane Bimczok, Anne Müller, and Phillip D. Smith

    27. Mucosal responses to helminth infections

    William Gause and Richard Grencis

    28. Viral infections

    Sarah Elizabeth Blutt, Mary K. Estes, Satya Dandekar, and Phillip D. Smith

    29. Infection-driven periodontal disease

    Thomas E. Van Dyke and Mike Curtis

    30. Mucosal vaccine strategies

    Nils Lycke, Jan Holmgren, and Harry B. Greenberg

    PART VII. SPECIFIC IMMUNE-MEDIATED DISEASES OF MUCOSAL SURFACES

    31. Celiac disease

    Bana Jabri and Ludvig M. Sollid

    32. IgA nephropathy

    Jan Novak, Bruce A. Julian, and Jiri Mestecky

    33. Mucosal manifestations of immunodeficiencies

    Scott Snapper, Jodie Ouahed, and Luigi D. Notarangelo

    34. Inflammatory bowel disease

    Giovanni Monteleone, Markus F. Neurath, and Britta Siegmund

    35. Food allergies and eosinophilic gastrointestinal diseases

    Cathryn Nagler and Glenn T. Furuta

    Index

    Biography

    The Society for Mucosal Immunology advances research and education related to the field of mucosal immunology.

    Phillip D. Smith, MD, is Professor of Medicine and Microbiology and The Mary J Bradford Professor of Gastroenterology, Department of Medicine at the University of Alabama at Birmingham, Alabama.

    Thomas T. MacDonald, PhD, FRCPath, FMedSci, is Dean for Research and Professor of Immunology, Centre for Immunology and Infectious Disease, at Barts and the London School of Medicine and Dentistry, London.

    Richard S. Blumberg, MD, is Professor of Medicine, Harvard Medical School, Chief, Gastroenterology and Hepatology Division, Brigham and Women’s Hospital, Boston, Massachusetts.