1st Edition

Prognostic and Predictive Factors in Gynecologic Cancers

    Gynecologic oncology takes a fresh look at a critical aspect of cancer treatment planning. An international team of authors reviews the traditional prognostic and predictive factors such as tumor grade, histologic subtype, and grade and then goes a step further to review the growing number of molecular discoveries that have increasing clinical significance. The book is organized into comprehensive sections on ovarian, endometrial and cervical cancer and includes up to date reviews, newly discovered molecular pathways, genetic markers, molecular imaging techniques, and their relevance to clinical medicine.

    Prognostic and Predictive Factors in Gynecologic Oncology is illustrated with over 100 figures and is essential reading for oncologists, translational and basic scientists, as well as fellows, residents and students with a special interest in gynecologic oncology.

    Part I. Ovary 1. Clinical predictors of outcome in epithelial ovarian carcinoma 2. Influence of BRCA1 and BRCA2 on survival 3. Cell-cycle and apoptotic markers 4. p53 as a prognostic factor 5.Use of microarray and CGH technologies for predicting outcome 6. Angiogenesis and epithelial ovarian carcinoma 7. Cell-adhesion and matrix-associated proteins in ovarian carcinoma 8. Effect of immune factors on prognosis 9. Predictive factors in germ-cell and stromal tumors Part II. Endometrium 10. Rethinking traditional surgical-pathologic criteria for early stage endometrial cancer: studies of patterns of failure 11. Molecular prognostic and predictive factors in advanced endometrial cancer: implications for therapy 12. Inherited and acquired mismatch repair deficiency 13. Molecular profiling in endometrial cancer: Current research and implications for the future 14. Traditional and molecular predictors of behavior in uterine papillary serous carcinoma and clear cell carcinoma Part III. Cervical 15. Clinical pathologic predictors in patients with cervical cancer 16. Predictors of radiation sensitivity and resistance 17. Molecular prognostic and predictive factors for cervix cancer 18. Virology in the prevention and management of cervical cancer 19. Molecular imaging for cervical cancer 20. Neuroendocrine cancer of cervix: prognostic and predictive factors 21. Predictive values of sentinel lymph nodes


    Charles F. Levenback, Anil Sood, Karen H Lu, Robert Coleman