1st Edition
Proteasomes: The World of Regulatory Proteolysis
389 Pages
68 B/W Illustrations
by
CRC Press
389 Pages
by
CRC Press
Also available as eBook on:
This book highlights proteasome structures and how they are related to different aspects of proteasome function. Moreover, the book reports on the functional roles these highly developed proteolytic machines play within the cell. It was a great surprise to the scientific world that proteolysis provides crucial functions in cellular regulation. The surprise was even greater when it was found that... Read more
1. Proteasomes: A Historical Retrospective 2. Proteasomes in Prokaryotes 3. Proteasome Crystal Structures 4. Subunit Arrangement in the Human Proteasome 5. Active Sites and Assembly of the 20S Proteasome 6. The Regulatory Particle of the Yeast Proteasome 7. The Mammalian Regulatory Complex of the 26S Proteasome 8. The 20S Proteasome Activator PA28 or 1IS Regulator 9. Proteasome Activators and Synthetic Modulators 10. The Proteasome Inhibitors and Their Uses 11. Intracellular Localization of Proteasomes 12. Primary Destruction Signals 13. The Ubiquitin System in Yeast 14. The Ubiquitin-Proteasome Pathway in Mammals: Mechanisms of Action and Involvement in Pathogenesis of Human Diseases 15. Deubiquitinating Enzymes and the Regulation of Proteolysis 16. Degradation of Ornithine Decarboxylase, a Ubiquitin-independent Proteasomal Process 17. The Ubiquitin-Proteasome System in Cell Cycle Control 18. p53 and the Proteasome Pathway 19. The Role of the Proteasome in Apoptosis 20. Function of the Proteasome in the Protein Quality Control Process of the Endoplasmic Reticulum 21. M H C Class I Antigen Presentation and the Proteasome Pathway 22. Ubiquitin, Proteasomes and Neurodegenerative Disease 23. The Proteasome in Posttranscriptional Control: A Protease with Endonuclease Activity?
Biography
Wolfgang Hilt, Institut fur Biochemie Universitat Stuttgart Stuttgart, Germany. Dieter H. Wolf, lnstitut fur Biochemie Universitat Stuttgart Stuttgart, Germany.
