Protein Folding and Metal Ions: Mechanisms, Biology and Disease, 1st Edition (Hardback) book cover

Protein Folding and Metal Ions

Mechanisms, Biology and Disease, 1st Edition

Edited by Cláudio M. Gomes, Pernilla Wittung-Stafshede

CRC Press

308 pages | 75 B/W Illus.

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The role of metal ions in protein folding and structure is a critical topic to a range of scientists in numerous fields, particularly those working in structural biology and bioinorganic chemistry, those studying protein folding and disease, and those involved in the molecular and cellular aspects of metals in biological systems. Protein Folding and Metal Ions: Mechanisms, Biology and Disease presents the contributions of a cadre of international experts who offer a comprehensive exploration of this timely subject at the forefront of current research.

Divided into four sections, this volume:

  • Provides case study examples of protein folding and stability studies in particular systems or proteins that comprise different metal ions of co-factors
  • Reviews the proteins that shuttle metal ions in the cell to a particular target metalloprotein
  • Illustrates how metal binding can be connected to pathological protein conformations in unrelated diseases, from cancer to protein deposition disorders such as Parkinson’s disease
  • Addresses protein redesign of metal-containing proteins by computational methods, folding simulation studies, and work on model peptides — dissecting the relative energetic contribution of metals sites to protein folding and stability

Together, the 13 chapters in this text cogently describe the state of the science today, illuminate current challenges, propose future possibilities, and encourage further study in this area that offers much promise especially with regard to novel approaches to the treatment of some of the most challenging and tragic diseases.

Table of Contents


Metal Ions, Protein Folding, and Conformational States: An Introduction, Cláudio M. Gomes and Pernilla Wittung-Stafshede

The Folding Mechanism of c-Type Cytochromes, Carlo Travaglini-Allocatelli, Stefano Gianni, and Maurizio Brunori

The Mechanism of Cytochrome c Folding: Early Events and Kinetic Intermediates, Eefei Chen, Robert A. Goldbeck, and David S. Kliger

Stability and Folding of Copper-Binding Proteins, Irina Pozdnyakova and Pernilla Wittung-Stafshede

Iron-Sulfur Clusters, Protein Folds, and Ferredoxin Stability, Sónia S. Leal and Cláudio M. Gomes

Folding and Stability of Myoglobins and Hemoglobins, David S. Culbertson and John S. Olson


Frataxin: An Unusual Metal-Binding Protein in Search of a Function, Annalisa Pastore

Mechanism of Human Copper Transporter Wilson’s Disease Protein, Amanda Barry, Zara Akram, and Svetlana Lutsenko


α-Synuclein and Metals, Aaron Santner and Vladimir N. Uversky

Zinc and Misfolding, James S. Butler and Stewart N. Loh

The Octarepeat Domain of the Prion Protein and Its Role in Metal Ion Coordination and Disease, Glenn L. Millhauser


Metallopeptides as Tools to Understand Metalloprotein Folding and Stability, Brian R. Gibney

The Folding Landscapes of Metalloproteins, Patrick Weinkam and Peter G. Wolynes

About the Editors

Cláudio M. Gomes is group leader at the Instituto Tecnologia Química e Biológica, a research institute affiliated with the Universidade Nova de Lisboa, Oeiras, Portugal. Born in 1970, Cláudio earned his PhD from the Instituto Tecnologia Química e Biológica in 1999, as a Gulbenkian PhD program in biology and medicine graduate. From 2000 onward, he gradually switched his research interests from bioenergetics and metalloprotein structure-function toward protein folding and structural biophysics of misfolding diseases. Until setting up his independent laboratory in 2003, he was assistant professor at the Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, where he started teaching in 2000. Cláudio has published more than 70 peer-reviewed papers.

Pernilla Wittung-Stafshede has been a professor in biological chemistry in the Chemistry Department at Umeå University, Umeå, Sweden since 2008. Born in 1968, she earned a PhD in physical chemistry from Chalmers University, Gothenburg, Sweden, in 1996. During 1997–1998, she did a postdoctoral period at Caltech, Pasadena, California. In 1999 she began her independent research career, with a focus on the role of metals in protein folding, as a chemistry professor at Tulane University, New Orleans, Louisiana. After 5 years at Tulane, she moved to Rice University, Houston, Texas in 2004 and became a professor in biochemistry. Pernilla has graduated 10 PhD students to date, has obtained several awards, and has published over 150 peer-reviewed papers.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Chemistry / General
SCIENCE / Chemistry / Inorganic
SCIENCE / Life Sciences / Biology / Molecular Biology
SCIENCE / Physics