1st Edition
Protein Misfolding in Neurodegenerative Diseases Mechanisms and Therapeutic Strategies
Edited By Robert D. E. Sewell
Copyright 2008
596 Pages
by
CRC Press
596 Pages
by
CRC Press
592 Pages
by
CRC Press
Also available as eBook on:
Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and... Read more
INTRODUCTION. Protein Folding. ALZHEIMER’S DISEASE. Alzheimer’s Disease: Epidemiology, symptoms and clinical pathology. Improving Cholinergic Transmission. Reduction in Plaque Formation. Carbonic Anhydrase Activation. Reduction of Intracellular Neurofibrillary Tangles from Tau Protein. Oxidative Stress Reduction. Enhancement of Brain Retinoic Acid Levels. Sulfatase Inhibitors and Cognitive Enchancement. PARKINSON’S DISEASE. Epidemiology, Symptoms and Clinical Pathology. Restoring Dopamine Levels. Anticholinergics. RARER NEURODEGENERATIVE DISEASES. Huntington’s Disease. Amyotrophic Lateral Sclerosis (Motor Neurone Disease). Transmissible Spongiform Encephalopathies (TSEs) – Bovine Spongiform Encephalopathy (BSE) – Creutzfeldt-Jacob Disease (CJD, vCJD) – Scrapie. Overview – Common Role of Protein Misfolding in Neurodegenerative Diseases.
Biography
H. John Smith, Claire Simons, Robert D. E. Sewell
