Protein-Solvent Interactions  book cover
1st Edition

Protein-Solvent Interactions

Edited By

Roger Gregory

ISBN 9780824792398
Published January 4, 1995 by CRC Press
592 Pages

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Book Description

This work covers advances in the interactions of proteins with their solvent environment and provides fundamental physical information useful for the application of proteins in biotechnology and industrial processes. It discusses in detail structure, dynamic and thermodynamic aspects of protein hydration, as well as proteins in aqueous and organic solvents as they relate to protein function, stability and folding.

Table of Contents

The new paradigm for protein research; solvent interactions with proteins as revealed by X-ray crystallographic studies; protein hydration and glass transition behavior; dielectric studies of protein hydration; protein dynamics - hydration, temperature and solvent viscosity effects as revealed by Rayleigh Scattering of Mossbauer Radiation (RSMR); proteins in essentially non-aqueous environments; solvent viscosity effects on protein dynamics - updating the concepts; effect of solvent on protein internal dynamics - the kinetics of ligand binding to myoglobin; solvent effects on protein stability and protein association; thermodynamic mechanisms for enthalpy-entropy compensation; preferential interactions of water and cosolvents with proteins; thermodynamic nonideality and protein solvation; molecular basis for protein separations.

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". . .a broad and much-needed survey of biophysical aspects of the interplay between proteins and their solvent. . . . . .uniformly well-written. . .of value to anyone with an active interest in the physical chemistry of proteins. "
---FEBS Letters