Proteins and Peptides : Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes book cover
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Proteins and Peptides
Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes





ISBN 9780367385057
Published October 10, 2019 by CRC Press
288 Pages

 
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Book Description

Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.

Key features include:

  • issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics


  • lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones


  • innovations for protein and peptide delivery such as needle-less delivery


  • strategies for delivery of these molecules to locations such as the eye and brain


  • generic issues of proteins and peptides
  • Table of Contents

    In Vitro/In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Hematologic Growth Factors and Cytokines. In Vitro–In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Antibody Therapeutics. In Vitro/In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Extracellular Matrix–Binding Growth Factors. Metabolic Processes at Injection Sites Affecting Pharmacokinetics, Pharmacodynamics, and Metabolism of Protein and Peptide Therapeutics. Local Tissue Responses to Polymer Implants Affecting Pharmacokinetics, Pharmacodynamics, and Metabolism of Proteins and Peptides. Engineering as a Means to Improve the Pharmacokinetics of Injected Therapeutic Proteins. Ophthalmic Delivery of Protein and Peptide Therapeutics; Pharmacokinetics, Pharmacodynamics, and Metabolism Considerations. Pharmacokinetic and Pharmacodynamic Aspects of Intranasal Delivery. Oral Delivery of Protein and Peptide Therapeutics: PK/PD and Metabolism Considerations. Drug Interaction Studies of Therapeutic Biologics: Protein and Peptide Actions and Interactions That Alter Their Pharmacokinetics, Pharmacodynamics, and Metabolism. Intersection of Pharmacogenomics with Pharmacokinetics and Pharmacodynamics.

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    Editor(s)

    Biography

    Randall J. Mrsny, Ann Daugherty