Proteotronics: Development of Protein-Based Electronics, 1st Edition (Hardback) book cover

Proteotronics

Development of Protein-Based Electronics, 1st Edition

By Eleonora Alfinito, Jeremy Pousset, Lino Reggiani

Jenny Stanford Publishing

280 pages | 30 Color Illus. | 140 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9789814613637
pub: 2015-10-14
SAVE ~$32.00
$160.00
$128.00
x
eBook (VitalSource) : 9780429083532
pub: 2015-10-22
from $28.98


FREE Standard Shipping!

Description

Protein-mediated charge transport is of relevant importance in the design of protein-based electronics and in attaining an adequate level of understanding of protein functioning. This book reviews a variety of experiments devoted to the investigation of charge transport in proteins and presents a unified theoretical model to interpret macroscopic results in terms of the amino acids backbone-structure of the single protein. It aims to serve a broad audience of researchers involved in the field of electrical characterization of biological materials and in the development of new molecular devices based on proteins and also as a reference platform that surveys existing data and presents the basis for future development of a new branch of nano-electronics, which by mixing proteomics, that is, the large-scale study of proteins, particularly their structures and functions, and electronics is introduced here as proteotronics.

Reviews

"This book presents the first structured approach to the new field of protein-based electronics, which has opened possibilities for the development of new concepts of nanobiosensors for health applications. It presents a solid theoretical approach which is validated by the existing experimental evidence, and will be of relevance for both young and experienced researchers who are interested in the frontier between electronics and biology."

— Prof. Joan Bausells, Barcelona Microelectronics Institute (CSIC), Spain

"This book presents a newly emerging discipline, proteotronics, investigating the coupling between the protein world and electronics. It opens the field of protein-based nanobiosensors that are able to bypass the complicated sequence of biological events for signal generation in e-sensing."

— Prof. Nicole Jaffrezic-Renault, Institute of Analytical Chemistry, University of Lyon, France

"Alfinito and her coworkers have made the very first steps of analyzing the electrical transport characteristics of the building elements of potentially important protein-based electronics. Highly recommended reading for all those who are involved with these developments and anybody who is interested in these challenging issues."

— Prof. Lazlo B. Kish, Texas A&M University, USA

Table of Contents

Preface

Introduction

General on Proteins

Structural Properties

Structure Levels

Protein Folding

Experimental Techniques to Investigate Structure and Functions of Proteins

Classification of Proteins

Sensing Proteins

Type-One Opsins

G-Protein Coupled Receptors

GPCR Activation Models

Structure and Sensing Action

Electrical Characterization

Main Properties of Investigated Proteins

Electrical Properties: Experiments

General

Electrochemical Impedance Spectroscopy

Model Lipid Bilayer

Immobilization of GPCRs

Experimental Results

Carbon Nanotube Field-Effect-Transistor

Metal-Protein-Metal Structure: Thin Film Technique

Metal-Protein-Metal Structure: Nanolayer Technique

Atomic Force Microscopy Technique

Electrical Properties: Theory

Theoretical Model

Impedance Random Network

Electrical Properties of a Single Protein

Network Properties of the Protein Under Test

Calculation of a Single-Protein Molecular Volume

Conformational Process: General

Conformation Process: Coordinate Model

Conformation Process: Length Model

Topological Investigation

Resistance and Impedance Spectrum

Random Fluctuations in the Impedance Network

Dynamic Fluctuations of the Impedance Network: Oscillator Models

Classical Harmonic Oscillator

Link oscillation model

Node Oscillation Model

Results on Average Quantities

Variance of Impedance Fluctuations

Quantum Harmonic Oscillator

Current-Voltage Characteristics

Bacteriorhodopsin as Testing Prototype

Modeling

Topological Properties

Current–Voltage Characteristics

Scaling and Universality of High-Field Conductance in Bacteriorhodopsin Monolayers

Global Quantities

Generalized Gumbel Distributions

Discussion

Conclusion

Survey of Other Proteins

Proteorhodopsin

Modeling

Topological Properties

Experiments

A Comparative Analysis of Proteorhodopsin and Bacteriorhodopsin Electrical Properties

Protein Resistance

Small-signal electrical properties

Current–voltage characteristics

Conclusion

Bovine Rhodopsin

Modeling

Engineering of Bovine Rhodopsin Spatial Structure

Small-Signal Electrical Properties

Current–Voltage Characteristics

Conclusion

Rat OR-I7

Modeling

Topological Properties

Small-Signal Electrical Properties

Current–Voltage Characteristics

Conclusion

Human OR 17-40

Modeling

Topological Properties

Protein Resistance

Small-Signal Electrical Properties

Conclusion

OR 7D4

Modeling

Topological Properties

Protein Resistance

Small-Signal Electrical Properties

Conclusion

Human OR 2AG1

Modeling

Topological Properties

Protein Resistance

Small-Signal Electrical Properties

Conclusion

Canine Cf OR 5269

Modeling

Topological Properties

Protein Resistance

Small-Signal Electrical Properties

Conclusion

Azurin

Modeling

Topological Properties

Protein Resistance

Current–Voltage Characteristics

Conclusion

AChE

Modeling

Topological Properties

Small-Signal Electrical Properties

Conclusion

Conclusion and Perspectives

Appendix: Computational Details

Calculation of Small-Signal Impedance Spectrum

Analysis of the Protein Equivalent Circuit Obtained from Calculations of Bovinerhodopsin and AChE

Calculations of Intrinsic Fluctuations of the Single-Protein Impedance Due to the Presence of Defects

Calculations of Intrinsic Fluctuations of the Single-Protein Impedance due to Thermal Fluctuations

Calculations of Static High-Field Current–Voltage Characteristics

Inclusion of the Fowler–Nordheim Tunneling Mechanism

List of acronyms

Bibliography

Index

About the Authors

Eleonora Alfinito is a researcher in condensed matter physics at the University of Salento, Lecce, Italy. Her research activity is founded on quantum field theory, physics of matter, and mathematical physics. At present, her main interests concern with the electrical properties of biological matter, proteins in particular, and the statistical characterization of electrical fluctuations.

Jeremy Pousset is a researcher at the Institute for Microelectronics and Microsystems of the National Research Council, Lecce, Italy. His research activity has been devoted to the problem of terahertz plasma waves in nano-devices and the development of Monte Carlo codes and the investigation of electron transport modelling of biological matter. Currently, he is working on the electrical characterization of organic materials.

Lino Reggiani is full professor in physics of matter at the University of Salento, where he is carrying out a research activity finalized to the study of electrical properties and fluctuations to characterize materials and devices to be used in nano-electronics and in the development of sensors. He has authored and co-authored over 500 scientific publications in specialized international magazines.

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
SCI055000
SCIENCE / Physics
SCI086000
SCIENCE / Life Sciences / General
TEC008000
TECHNOLOGY & ENGINEERING / Electronics / General