237 Pages
35 B/W Illustrations
by
CRC Press
237 Pages
by
CRC Press
Also available as eBook on:
Using as a theme the encounter between protozoan parasites and macrophages, this volume brings together cell biologists, immunologists and protozoologists to review current developments in this broad and dynamic research area. Discussed are ways protozoans establish their intracellular niche, how they activate macrophage effector functions, what these functions are, and means by which several... Read more
Introduction: Macrophage Biology, What Is a Macrophage? Macrophage Origin; Activation States of Macrophages; Types of Macrophages; Recognition and Destruction by Macrophages and Subversion by Pathogens 1. Invasion and Intracellular Survival by Toxoplasma 2. Macrophages, Alternative Niches for Intracellular Growth of Trypanosomacnm 3. Macrophage - Leishmania Interactions: Complexities and Uncertainties from the Study o f Leishmaniasis in Viv o 4. Innate Recognition, Cell Signaling and Pro-Inflammatory Response during Infection with Trypanosoma cruzi 5. Modulation of Positive Signaling and Proinflammatory Responses by Hemozoin, a Plasm odium Metabolic Waste 6. Pro-Inflammatory Responses and Cell Signaling during Malaria Infection: The Parasite Glycosylphosphatidylinositol igand7. Pro-Inflammatory Responses in Macrophages during Toxoplasma gondii Infection 8. Down-Modulation of Proinflammatory Signal Transduction in Toxoplasma gondii-Infected Macrophages 9. Avoidance of Innate Immune Mechanisms by the Protozoan Parasite, Leishmaniaspp 10. Survival Strategies of Toxoplasma gondir. Interference with Regulatory and Effector Functions of Macrophages. 11. Targeting SHP-1 to Prevent Macrophage Activation Promotes Leishmania Pathogenesis 12. Negative Signaling and Modulation of Macrophage Function in Trypanosomacruzi Infection 13. Effector Functions of Macrophages in Plasmodium Parasite Infections 14. Innate Control of Toxoplasma gondii through Macrophage-Based Effector Mechanisms 15. Phagocyte Effector Functions against Leishmania Parasites 16. Effector Mechanisms of Macrophages Infected
Biography
Eric Y. Denkers, Ph.D. Department of Microbiology and Immunology College of Veterinary Medicine Cornell University, Ithaca, New York, U.S.A. Ricardo T. Gazzinelli, Ph.D. Laboratory of Immunopathology Rene Rachou Research Center - FIOCRUZ Belo Horizonte, MG, Brazil and Division of Infectious Diseases and Immunology University of Massachusetts Medical School Worchester, Massachusetts, U.S.A.
