Pulmonary Nanomedicine : Diagnostics, Imaging, and Therapeutics book cover
1st Edition

Pulmonary Nanomedicine
Diagnostics, Imaging, and Therapeutics

Edited By

Neeraj Vij

ISBN 9789814316484
Published August 6, 2012 by Jenny Stanford Publishing
300 Pages 14 Color & 10 B/W Illustrations

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Book Description

This book provides an in-depth view on engineered nanomaterials (ENM) pulmonary effects and familiarizes readers with unique aspects of nanomaterial application and research, such as the effects of physicochemical properties on cellular uptake and toxicity. It focuses on the diagnostic and therapeutic utilities of nanomaterials in different lung diseases. The book discusses the novel applications of nanotechnology for the treatment of airway diseases such as asthma, allergy, chronic obstructive pulmonary diseases, cystic fibrosis, and lung cancer. It also discusses the strategies to overcome the pathophysiological and technical barriers as an attempt to synchronize the efforts of pulmonary biologists, chemists and clinicians to develop novel nano-based diagnostics, imaging, and therapeutics tools for airway diseases.

Table of Contents

Theranostic Applications of Nanotechnology in Chronic Obstructive Lung Diseases Neeraj Vij and Aakruti Gorde
Pulmonary Physiology and Pathogenesis of Chronic Obstructive Lung Diseases
Application of Nano-Based Systems in Treating Chronic Obstructive Lung Diseases
Multifunctional Tumor-Targeted Nanoparticles for Lung Cancer Shinji Kuroda, Tomohisa Yokoyama, Justina O. Tam, Ailing W. Scott, Li Leo Ma, Manish Shanker, Jiankang Jin, Corbin Goerlich, David Willcutts, Jack A. Roth, Konstantin Sokolov, Keith P. Johnston, and Rajagopal Ramesha
Biomarkers for Tumor Targeting
Nanotechnology in Medicine
EGFR-Targeted Hybrid Plasmonic Magnetic Multifunctional Nanoparticles
Nasal and Pulmonary Delivery of Macromolecules to Treat Respiratory and Nonrespiratory Diseases Durga Paturi, Mitesh Patel, Ranjana Mitra, and Ashim K. Mitra
Nasal Drug Delivery
Pulmonary Drug Delivery
In vitro and in vivo Diagnosis of Pulmonary Disorders Using Nanotechnology Indrajit Roy
In vitro Diagnosis, Techniques, and Challenges
In vivo Diagnosis, Challenges, and Techniques
Toxicological Studies Using Nanoparticles
Nanoparticles for Targeting T Cells in Allergy and Inflammatory Airway Conditions Adham Bear, Laura B. Carpin, Conrad R. Cruz, Rebekah A. Drezek, and Aaron E. Foster
Role of T Cells in the Pathogenesis of Asthma
Treatment Strategies for Asthma
Potential T Cell–Targeted Strategies for Nanoparticle-Based Therapies
T Cell-Targeting Ligands
Alternative Approaches
Multifunctional Chitosan Nanocarriers for Respiratory Disease Gene Therapy Shyam S. Mohapatra, Subhra Mohapatra, Gary Hellermann, and Rhonda R. Wilbur
Therapeutic Effects and Safety of Chitosan in Human Disease
Safety and Efficacy Studies in Dogs
Safety of Chitosan-Gene Nanocomplexes in Nonhuman Primates
Respiratory Disease Applications
Future of Immunotherapy
Concluding Remarks
Targeted Delivery to the Pulmonary Endothelium Yifei Zhang, Jiang Li, Xiang Gao, and Song Li
Pulmonary Endothelium as a Target for Drug Delivery
Targeting the Pulmonary Endothelium for Imaging and Therapeutic Applications
Nanosystems for Selective Epithelial Barrier Targeting in Chronic Airway Diseases Heather A. Parsons, Rachel L. Damico, and Venkataramana K. Sidhaye
Obstructive Lung Diseases
NP Delivery of Airway Diseases
Toxicity of NPs
Conclusions and Future Directions
Potential Respiratory Health Risks of Engineered Carbon Nanotubes James C. Bonner, Jeffrey W. Card, Stavros Garantziotis, and Darryl C. Zeldin
Immune Cell Interaction with CNTs
Fibrogenic Reactions to CNTs
CNTs and Preexisting Allergic Asthma
CNTs and LPS-Induced Airway Inflammation
Effects of CNTs on Other Organ Systems
DNA Damage and Aneuploidy Caused by CNTs
Pleural Toxicity of CNTs

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"Pulmonary Nanomedicine presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases. It describes numerous drug delivery, gene delivery, and theragnostic approaches for managing pulmonary disease outcomes. The book’s editor, Dr. Neeraj Vij, is an expert in pulmonary medicine and has done an excellent job in producing a high-class textbook."
—Prof. Rajiv R. Mohan - University of Missouri—Columbia, USA

"This book is a comprehensive treatise on emerging nanotechnology applications in the diagnosis and treatment of pulmonary diseases. It beautifully presents new drug delivery, gene delivery, and theragnostic approaches to improve pulmonary disease outcomes."
—Prof. Uday B. Kompella - University of Colorado, USA