1st Edition

Pulsed Electromagnetic Fields for Clinical Applications

Edited By Marko Markov, James Ryaby, Eric I. Waldorff Copyright 2020
    280 Pages
    by CRC Press

    280 Pages 25 B/W Illustrations
    by CRC Press

    Pulsed Electromagnetic Fields for Clinical Applications presents the historical development, the state of art, and the future of the application of pulsed electromagnetic fields (PEMFs) for the treatment of various medical problems, including initiating various healing processes from delayed fractures and pain relief to multiple sclerosis and Parkinson’s disease. The emphasis is on the development of scientific methods to be implemented in clinical application.

    In perspective, this modality provides a practical, exogenous method for inducing cell and tissue modification attempted to the injured tissues to their normal physiological status. The book reviews the current state of equipment for PEMFs and highlights worldwide therapeutic achievements.

    • It explores the past, present, and future of PEMF therapies.

    • It presents the development of theory and laboratory research during the last 70 years.

    • It reviews the available equipment for PEMF.

    • It reviews the state of the art of worldwide therapeutic achievements.

    • It includes recent achievements and applications of electroporation modalities.

    1. Electric-Electromagnetic Stimulation-Electroporation  2. Pulsed Electromagnetic Fields: From Signaling to Healing  3. Biophysical stimulation of bone growth in fractures  4. Biophysical stimulation of articular cartilage for chondroprotection and chondroregeneration  5. Electromagnetic Field Effects on Soft Tissues – Muscles and Tendons  6. Clinical use of pulsed electromagnetic fields (PEMFs)  7. Electromagnetic Fields in relation to Cardiac and Vascular Function  8. Towards ELF magnetic fields for the treatment of cancer  9. Terahertz electromagnetic fields in diagnostic and therapeutic settings – potentials and challenges  10. Nano-Pulse Stimulation therapy: a novel, non-thermal method for clearing skin lesions  11. Calcium Electroporation – A Novel Treatment to Overcome Cancer-Mediated Immune Suppression  12. A History of Pulsed Electromagnetic Fields  13. A Brief History of Orthofix Medical Inc. Bio-Stimulation  14. History of the Frank Reidy Research Center for Bioelectrics


    Marko S. Markov received his BS, MS and PhD from Sofia University, Bulgaria. He has been Professor and Chairman of the Department of Biophysics and Radiobiology at Sofia University for 22 years. He had been invited professor and lecturer in a number of European, Japanese and American academic and industry entities. For the years his research was on biological and clinical studies of the effects of various electromagnetic fields. He is a founder and member of the Editorial board of the journal "Electromagnetic biology and medicine". He has ben author and co-author of more that 200 peer-reviewed papers. Dr. Markov is author, editor and co-editor of 26 books, published by Plenum Press, Springer, Marcel Dekker and CRC. His book "Electromagnetic fields in biology and medicine" published by CRC Press is being translated on mandarin in China.

     Jim Ryaby, PhD joined Orthofix as Chief Scientific Officer in July 2013 after serving as a consultant. Before joining the Company, he served as Vice President of Research and Clinical Affairs for musculoskeletal applications at Mesoblast. Dr. Ryaby has also held the position of Senior Vice President of Research and Clinical Affairs and Chief Scientific Officer at OrthoLogic Corp in Tempe, AZ.  where he led the development of the CMF technology for spine fusion and nonunions and the TP508 peptide therapeutic development program in orthopedic and diabetic ulcer applications. Additionally, he has served as Adjunct Professor of Bioengineering at Arizona State University. Dr. Ryaby received his PhD degree in cellular and molecular biology from the Mt. Sinai School of Medicine, New York.

    Erik I. Waldorff, PhD, is the Principal Scientist and Research Manager for the orthopedic medical device company, Orthofix, which he joined in 2012. Prior to this Dr. Waldorff served as a Clinical Research Scientist for the Neuromodulation Division at St. Jude Medical (now Abbott) where he performed pre-clinical studies in addition to post-market clinical trials for spinal cord stimulation and deep brain stimulation patients. In addition following his doctoral studies, Dr. Waldorff held a position as a Postdoctoral Fellow at the Michigan Institute for Clinical and Health Research (MICHR) at the University of Michigan where he led orthopaedic human and animal studies. Dr. Waldorff received his PhD and MSE degrees in Biomedical Engineering and MSE and BSE degrees in Aerospace Engineering from the University of Michigan (Ann Arbor, Michigan).