1st Edition
Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs
Part One. Isotopically Labeled Analog as Internal Standard for Drug Quantitation — Methodology
Quantitation of Drug in Biological Specimen — Isotopically Labeled Analog of the Analyte as Internal Standard
Introduction
Significance of Accurate Quantitation
Preferred Calibration Method
Internal Standard and Quantitation Ions
Inadequate Isotopic Purity — An Extrinsic Factor
Cross-Contribution Derived from Ion Fragmentation Mechanism — An Intrinsic Factor
Fitting Calibration Data
2
H- Versus 13C-Analogs as Internal StandardsConcluding Remarks
References
Isotopically Labeled Analog of the Analyte as Internal Standard for Drug Quantitation — Chemical Derivatization and Data Collection and Evaluation
Introduction
Chemical Derivatization
Production of Most Favorable Ion-Pairs for Drug Quantitation
Exemplar Studies
Isotopically Labeled Analogs and Chemical Derivatization Groups
Ion Intensity Cross-Contribution Data
Full-Scan Mass Spectra
Selected Ion Monitoring and Calculation of Cross-Contribution Data:
Direct Measurement, Normalized Direct Measurement, Internal Standard Method, Standard Addition Method
Assessing the Accuracy of Empirically Determined Cross-Contribution Data:
Experimentally Observed Concentration, Theoretically Calculated Concentration, Comparing Empirically Derived and Theoretically Calculated Concentrations — Graphic Presentation, Summary
Compilation of Full-Scan Mass Spectra and Ion Intensity Cross-Contribution Tables:
Derivatization Procedures, Instrumentation, and Analytical Parameters
Collection of Mass Spectrometric Data
Ion Intensity Cross-Contribution Data
Concluding Remarks
References
Part Two. Mass Spectra of Commonly Abused Drugs and Their Isotopically Labelled Analogs in Various Derivatization Forms
Table of Contents for Appendix One
Stimulants
Opioids
Hallucinogens
Depressants/Hypnotics
Antianxiety Agents
Antidepressants
Others
Part Three. Cross-Contributions of Ion Intensity Between Analytes and Their Isotopically Labeled Analogs in Various Derivatization Forms
Table of Contents for Appendix Two
Stimulants
Opioids
Hallucinogens
Depressants/Hypnotics
Antianxiety Agents
Antidepressants
Others
Index
Biography
Ray H. Liu is a professor in the Department of Medical Technology at Fooyin University in Taiwan and professor emeritus in the Department of Justice Sciences at the University of Alabama in Birmingham. Sheng-Meng Wang is a professor of forensic science and director of scientific laboratories at Central Police University in Taiwan. Dennis V. Canfield is the manager of the Bioaeronautical Sciences Research Laboratory at the U.S. Federal Aviation Administration’s Civil Aerospace Medical Institute (CAMI) in Oklahoma City, Oklahoma.
The information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs.
—Maria Reid, Royal Canadian Mounted Police, Canadian Society of Forensic Science, Vol. 43, No. 1, March 2010The book is of obvious utility to those analysts who work in
drug analysis and to those who are confronted occasionally with
a drug-analysis problem. The strategies outlined in this work are
important to anyone who is conducting trace analysis by
chromatography coupled with mass spectrometry.
—Michael L. Gross, Journal of the American Society for Mass Spectrometry
