Quantitative Biology: From Molecular to Cellular Systems, 1st Edition (Hardback) book cover

Quantitative Biology

From Molecular to Cellular Systems, 1st Edition

Edited by Michael E. Wall

CRC Press

392 pages | 21 Color Illus. | 111 B/W Illus.

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pub: 2012-08-25
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Quantitative methods are revolutionizing modern molecular and cellular biology. Groundbreaking technical advances are fueling the rapid expansion in our ability to observe, as seen in multidisciplinary studies that integrate theory, computation, experimental assays, and the control of microenvironments. Integrating new experimental and theoretical methods, Quantitative Biology: From Molecular to Cellular Systems gives both new and established researchers a solid foundation for starting work in this field.

The book is organized into three sections:

  • Fundamental Concepts covers bold ideas that inspire novel approaches in modern quantitative biology. It offers perspectives on evolutionary dynamics, system design principles, chance and memory, and information processing in biology.
  • Methods describes recently developed or improved techniques that are transforming biological research. It covers experimental methods for studying single-molecule biochemistry, small-angle scattering from biomolecules, subcellular localization of proteins, and single-cell behavior. It also describes theoretical methods for synthetic biology and modeling random variations among cells.
  • Molecular and Cellular Systems focuses on specific biological systems where modern quantitative biology methods are making an impact. It incorporates case studies of biological systems for which new concepts or methods are increasing our understanding. Examples include protein kinase at the molecular level, the genetic switch of phage lambda at the regulatory system level, and Escherichia coli chemotaxis at the cellular level.

In short, Quantitative Biology presents practical tools for the observation, modeling, design, and manipulation of biological systems from the molecular to the cellular levels.

Table of Contents

Free Energies, Landscapes, and Fitness in Evolution Dynamics, Robert H. Austin

System Design Principles, Michael A. Savageau

Chance and Memory, Theodore J. Perkins, Andrea Y. Weiße, and Peter S. Swain

Information Theory and Adaptation, Ilya Nemenman

Quantitative In Vitro Biochemistry, One Molecule at a Time, Jeffrey A. Hanson and Haw Yang

Small-Angle Scattering, Cy M. Jeffries and Jill Trewhella

Subcellular Signaling Dynamics, Jeffrey J. Saucerman and Jin Zhang

Single-Cell Behavior, Philippe Cluzel

Modeling Genetic Parts for Synthetic Biology, Ying-Ja Chen, Kevin Clancy and Christopher A. Voigt

Modeling Cellular Variability, Brian Munsky

PKA: Prototype for Dynamic Signaling in Time and Space, Susan S. Taylor and Alexandr P. Kornev

Stochastic Simulation of the Phage Lambda Gene Regulatory Circuitry, John W. Little and Adam P. Arkin

Chemotaxis, Howard C. Berg

About the Editor

Michael E. Wall is with the Computer, Computational, and Statistical Sciences Division of the Los Alamos National Laboratory in New Mexico.

About the Series

Chapman & Hall/CRC Mathematical Biology Series

This series aims to capture new developments in mathematical biology, as well as high quality work summarizing or contributing to more established topics. Publishing a broad range of textbooks, reference works, and handbooks, the series is designed to appeal to students, researchers, and professionals in mathematical biology, as well as interdisciplinary researchers involved in associated fields.

For more information or to submit a book proposal, please contact Callum Fraser ([email protected]) or Bob Ross ([email protected])

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Biotechnology
SCIENCE / Life Sciences / Biology / Molecular Biology
SCIENCE / Physics