Precision medicine involves the treatment of diseases through a therapeutic strategy precisely tailored to a patient’s requirements. This book presents statistical methods for designing precision medicine strategies based on mapping the genetic interactions involved in drug response. It covers pharmacodynamic and pharmacokinetic processes and genetic mapping techniques. Both simulated and real examples illustrate the methods, with software code and data available online.
Table of Contents
Toward Precision Medicine. Principle of Study Design. Pharmacogenetic Detection: From Functional Mapping to Systems Mapping. Mapping Pharmacodynamic-Pharmacokinetic Interactions. Interplay Modeling of Pharmacodynamics-Pharmacokinetics and Disease Progression. Mapping Genes for Drug Resistance Dynamics. Genetic Mapping of Drug-Body Interactions. Pleiotropic Genes for Drug Efficacy and Toxicity. Reconstruction of Regulatory Networks toward Drug Response. Genetic Mapping of Drug Chronotherapy. Mathematical Issues of Systems Mapping. High-Dimensional Data Modeling in Clinical Pharmacogenomics. Future Directions. References. Index.