1st Edition

Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens

Edited By Romualdo Benigni Copyright 2003

    Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals.
    This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on

    General Introduction to QSAR. Mechanisms of Action of Chemical Carcinogens and their Role in Structure-Activity Relationships (SAR) Analysis and Risk Assessment. QSARs for Individual Classes of Chemical Mutagens and Carcinogens. QSARs for the Mutagenicity and Carcinogenicity of the Aromatic Amines. SAR in the Assessment of Carcinogenesis: the Multicase Approach. Predicting Mutagenicity of Congeneric and Diverse Sets of Chemicals Using Computed Molecular Descriptors: A Hierarchical Approach. Quantitative Structure-Activity Relationships for Acute Aquatic Toxicity: The Role of Mechanisms of Toxic Action in Successful Modelling. SARs and QSARs of Mutagens and Carcinogens: Understanding Action Mechanisms and Improving Risk Assessment.


    Romualdo Benigni