Offering lower toxicity and higher accuracy than conventional therapies, this source offers illustrative coverage of this new method to treat tumors associated with brain, breast, lung, and neuroendocrine cancers. Accompanied by a CD offering color images, radiolabeling procedures, and tips on radiopharmceutical administration, this source will offer comprehensive and expert guidance on this burgeoning therapeutic technique.
THEORY AND PRODUCTION OF PEPTIDES FOR RADIONUCLIDE THERAPY. Peptide Structure and Analysis. Molecular Pharmacology of Receptors. Receptors Distribution and Biochemical Characterization. RADIOLABELING MECHANISMS AND STRATEGIES. Developments of Radiolabeled Peptides. Receptor Targeting for Tumor Therapy with Radiopeptides. New Radionuclides for Peptide Therapy. Pre-Clinical Comparison of Radiolabeled Peptides for Radionuclide Therapy. CLINICAL THERAPEUTIC APPLICATIONS. Phase I Therapeutic Studies. Response to Treatment with Radiolabeled Peptides. Receptor Radionuclide Therapy: From 90Y to 177Lu Labeled Peptides. Therapeutic Potential of Radiolabeled Peptides with Beta and Alpha Emitters. Receptor-Mediated Radionuclide Therapy: The European Institute of Oncology Experience. DOSIMETRIC ASPECTS AND REGULATORY REQUIREMENTS. Radiation Dosimetry in Preparation to Therapy. Dosimetry and Critical Organs. Regulatory Requirements for Therapy Trials. FUTURE PERSPECTIVES. Advances in the Field of Radiopeptides for Therapy