Radiopharmaceuticals and Brain Pathophysiology Studied with Pet and Spect
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First published in 1991, this book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.
Table of Contents
Historical Background of PET (William Feindel). Recent Advances in Radiotracers for PET Studies of the Brain (Joanna S. Fowler and Alfred P. Wolf). Perfusion Radiotracers (Richard C. Reba and B. Leonard Holman). The Testing of Putative Receptor Binding Radiotracers In Vivo (W. C. Eckelman). PET Instrumentation for Quantitative Tracing of Radiopharmaceuticals (Iwao Kanno). SPECT: State-of-the-Art Scanners and Reconstruction Strategies (Ronald J. Jaszczak). Biochemistry of the BBB with Respect to Functional Analysis by PET (L. E. Feinendegen and H. Herzog). Kinetic Analysis of Glucose Tracer Uptake and Metabolism by Brain In Vivo (Albert Gjedde and Hiroto Kuwabara). 15O Studies with PET (E. Meyer). PET Studies of the Human Brain During Mental Activity. Some Theoretical and Practical Considerations (Lennart Widén). Use of PET to Evaluate Acute Stroke and Other Cerebrovascular Disorders (K. Herholz and W.-D. Heiss). Evaluation of Cerebral Hemodynamics with Positron Emission Tomography (William J. Powers). The Use of SPECT in Focal Epilepsy (Samuel F. Berkovic and Christopher C. Rowe). Mapping of Local Cerebral pH with Positron Emission Tomography (N. M. Alpert, M. Senda, and J. A. Correia). Regional Cerebral Metabolic and Structural Changes in Normal Aging and Dementia as Detected by PET and MRI (David W. Weiss, Elaine Souder, and Abass Alavi). Evaluation of Brain Tumors by PET (G. J. Meyer and O. Schober). Kinetic Analysis of Radioligand Binding in Brain In Vivo (Albert Gjedde). In Vivo Studies of the Central Benzodiazepine Receptors in the Human Brain with Positron Emission Tomography (Pascale Abadie and J.-C. Baron). Positron Emission Tomography (PET) Imaging of Neuroreceptors in Mental Illness (Henry N. Wagner, Jr.). The Study of Schizophrenia with SPECT (Jörg J. Pahl, Karim Rezai, Daniel S. O'Leary, and Nancy C. Andreasen). PET Studies of Movement Disorders (Mark Guttman and Gabriel Léger). Cognitive and Physiological Factors that Affect Regional Blood Flow and Other Measures of Brain Function (Karen Faith Berman and Daniel R. Weinberger). Index.