Radiopharmaceuticals and Brain Pathophysiology Studied with Pet and Spect  book cover
1st Edition

Radiopharmaceuticals and Brain Pathophysiology Studied with Pet and Spect

ISBN 9780367232580
Published September 30, 2021 by CRC Press
478 Pages

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Book Description

First published in 1991, this book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.

Table of Contents

1. Historical Background of PET.  2. Recent Advances in Radiotracers for PET Studies of the Brain.  3. Brain Perfusion Radiotracers.  4. The Testing of Putative Receptor Binding Radiotracers In Vivo.  5. PET Instrumentation for Quantitative Tracing of Radiopharmaceuticals.  6. SPECT: State-of-the-Art Scanners and Reconstruction.  7. Biochemistry of the BBB: Functional Analysis by PET.  8. Kinetic Analysis of Glucose Tracer Uptake and Metabolism by Brain In Vivo.  9. ¹⁵O Studies with PET.  10. PET Studies of the Human Brain During Mental Activity. Some Theoretical and Practical Considerations.  11. Use of PET to Evaluate Acute Stroke and Other Cerebrovascular Disorders.  12. Evaluation of Cerebral Hemodynamics with Positron Emission Tomography.  13. The Use of SPECT in Focal Epilepsy.  14. Mapping of Local Cerebral pH with Positron Emission Tomography.  15. Regional Cerebral Metabolic and Structural Changes in Normal Aging and Dementia as Detected by PET and MRI.  16. Evaluation of Brain Tumors by PET.  17. Kinetic Analysis of Radioligland Binding in Brain In Vivo.  18. In Vivo Studies of the Central Benzodiazepine Receptors in the Human Brain with Positron Emission Tomography.  19. Positron Emission Tomography (PET) Imaging of Neuroreceptors in Mental Illness.  20. The Study of Schizophrenia with SPECT.  21. PET Studies of Movement Disorders.  22. Cognitive and Physiological Factors that Affect Regional Blood Flow and Other Measures of Brain Function.  Index.

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