Radioprotectors: Chemical, Biological, and Clinical Perspectives, 1st Edition (Hardback) book cover

Radioprotectors

Chemical, Biological, and Clinical Perspectives, 1st Edition

By Edward A. Bump, Kamal Malaker

CRC Press

448 pages

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Hardback: 9780849347566
pub: 1997-12-29
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Description

It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics:

  • Early research on radioprotectors

  • WR-2721, an aminothiol prodrug, as a radioprotector

  • New results with naturally occurring thiols

  • Nitroxides as effective radioprotectors in vitro and in vivo

  • Radioprotection observed with radical scavengers or antioxidants

  • Bone marrow radioprotection with cytokines and biological modifiers

  • Multiple mechanisms of altering radiation response by eicosanoids

  • Vascular response to radiation and the importance of vascular damage to normal tissue

  • Modifiers of radiation-induced apoptosis

  • Survey of clinical trials with radioprotectors

    Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.

  • Table of Contents

    Chemical Aspects of Radioprotection

    Introduction, E.A. Bump

    History of Radioprotector Development, W. Foye

    The Mechanisms of Radioprotection by Non-Protein Sulfhydryls: Glutathione, Cysteine, and Cysteamine, C. Koch

    Aminothiols, D. Murray

    Stable Free Radicals As Radiation Protectors, S.M. Hahn, C.M. Krishna, and J.B. Mitchell

    Radioprotection by Superoxide Dismutase, R.M. Das

    DNA-Binding Bibenzimidazoles As Radioprotectors, R.F. Martin

    Protection against Radiation Damage to DNA Bases, A. Laayoun, J. Lhomme, M. Berger, and J. Cadet

    Biological Perspectives of Radioprotection

    Introduction, W.F. Blakely, J.F. Weiss, and E.A. Bump

    Eicosanoid-Induced Radioprotection and Chemoprotection: Laboratory Studies and Clinical Applications, W.R. Hanson

    Immunomodulators and Cytokines: Their Use in the Mitigation of Radiation-Induced Hemopoietic Injury, M.L. Patchen

    Modulation of the Radiation Response by Cytokines, R. Neta

    Radiation-Induced Apoptosis in Lymophoid Cells: Induction, Prevention, and Molecular Mechanisms, N. Ramakrishnan, J.F. Kalinich, and D.E. McClain

    Modulation of Radiation-Induced Apoptosis, S.T. Palayoor, R.E. Langley, C.N. Coleman, and E.A. Bump

    Chemoprevention with WR-2721 and Its Metabolites, J.S. Murley and D.J. Grdina

    Radioprotection of Normal Tissues

    Introduction, E.L. Travis

    Protection against Radiation Damage to Vascular Tissues, S.J. Braunhut

    Radiation Protection in the Developing Central Nervous System: Investigation of a Biological Approach, P. Mullenix

    Clinical Trials with Radioprotectors, K. Malaker

    Index

    Subject Categories

    BISAC Subject Codes/Headings:
    MED062000
    MEDICAL / Oncology
    MED080000
    MEDICAL / Radiology & Nuclear Medicine