Radioprotectors : Chemical, Biological, and Clinical Perspectives book cover
1st Edition

Chemical, Biological, and Clinical Perspectives

ISBN 9780849347566
Published December 29, 1997 by CRC Press
448 Pages

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Book Description

It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics:

  • Early research on radioprotectors
  • WR-2721, an aminothiol prodrug, as a radioprotector
  • New results with naturally occurring thiols
  • Nitroxides as effective radioprotectors in vitro and in vivo
  • Radioprotection observed with radical scavengers or antioxidants
  • Bone marrow radioprotection with cytokines and biological modifiers
  • Multiple mechanisms of altering radiation response by eicosanoids
  • Vascular response to radiation and the importance of vascular damage to normal tissue
  • Modifiers of radiation-induced apoptosis
  • Survey of clinical trials with radioprotectors
    Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.
  • Table of Contents

    Chemical Aspects of Radioprotection
    Introduction, E.A. Bump
    History of Radioprotector Development, W. Foye
    The Mechanisms of Radioprotection by Non-Protein Sulfhydryls: Glutathione, Cysteine, and Cysteamine, C. Koch
    Aminothiols, D. Murray
    Stable Free Radicals As Radiation Protectors, S.M. Hahn, C.M. Krishna, and J.B. Mitchell
    Radioprotection by Superoxide Dismutase, R.M. Das
    DNA-Binding Bibenzimidazoles As Radioprotectors, R.F. Martin
    Protection against Radiation Damage to DNA Bases, A. Laayoun, J. Lhomme, M. Berger, and J. Cadet
    Biological Perspectives of Radioprotection
    Introduction, W.F. Blakely, J.F. Weiss, and E.A. Bump
    Eicosanoid-Induced Radioprotection and Chemoprotection: Laboratory Studies and Clinical Applications, W.R. Hanson
    Immunomodulators and Cytokines: Their Use in the Mitigation of Radiation-Induced Hemopoietic Injury, M.L. Patchen
    Modulation of the Radiation Response by Cytokines, R. Neta
    Radiation-Induced Apoptosis in Lymophoid Cells: Induction, Prevention, and Molecular Mechanisms, N. Ramakrishnan, J.F. Kalinich, and D.E. McClain
    Modulation of Radiation-Induced Apoptosis, S.T. Palayoor, R.E. Langley, C.N. Coleman, and E.A. Bump
    Chemoprevention with WR-2721 and Its Metabolites, J.S. Murley and D.J. Grdina
    Radioprotection of Normal Tissues
    Introduction, E.L. Travis
    Protection against Radiation Damage to Vascular Tissues, S.J. Braunhut
    Radiation Protection in the Developing Central Nervous System: Investigation of a Biological Approach, P. Mullenix
    Clinical Trials with Radioprotectors, K. Malaker

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