Reactive Oxygen Metabolites: Chemistry and Medical Consequences, 1st Edition (Hardback) book cover

Reactive Oxygen Metabolites

Chemistry and Medical Consequences, 1st Edition

By Manfred K. Eberhardt

CRC Press

608 pages | 100 B/W Illus.

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pub: 2000-07-21
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Description

In recent years, the field of radical chemistry has undergone explosive growth. Although its roots lie in organic chemistry, the implications of its findings are having enormous impact in a broad range of disciplines, and we now have evidence for radical involvement in over 100 diseases. As important as this is, however, the subject of radicals and reactive oxygen metabolites (ROMs) is complex and barely touched upon in the curriculum of medical schools.

Reactive Oxygen Metabolites brings the subject within the grasp of even those with little preparation in chemistry. From the basic chemistry of radicals through the pathology, the author provides a clear and thorough introduction to ROMs and their importance to human health and disease. Exhaustively researched and referenced, this highly readable work will give you the ability to critically analyze and evaluate many pathological problems arising from the chemistry of ROMs and reduce them to their lowest common denominator. It is the ideal vehicle for people who need to understand the importance of reactive oxygen and nitrogen species in human health and disease but have neither the time, the inclination, nor perhaps the background to work their way through the mountain of original literature.

Reviews

"The author discusses the basic chemistry of reactive oxygen metabolites with great expertise and then applies this knowledge to the analysis of pathological processes. It is a treasure trove of information, but does not overwhelm and is fun to read. Due to the ever increasing importance of reactive oxygen metabolites, this text should be required reading in medical schools."

--Angel A. Roman Franco, M.D.

"…To write a single-authored, compact introductory text which encompasses all the different aspects of ROM chemistry, biology and pathology is a challenging task: the author has succeeded formidably…The text is throughout well referenced. It not only represents an easy to read overview of this complex interdisciplinary subject of biological and medical relevance, but serves also as a fountain of valuable information for more in-depth considerations. As an introductory text, this book should have wide appeal and is highly recommended. It should be a welcomed text for a special topic course at the interphase of chemistry, biology and medicine: I certainly would adopt it for my course at the advanced undergraduate and graduate level."

- Prof. Dr. W. Adam, Institut für Organische Chemie der Universität Würzburg

Table of Contents

THE PROS AND CONS OF LIVING IN AN OXYGEN ATMOSPHERE

BASIC CHEMISTRY OF RADICALS

Definition and History

Formation of Radicals

Reactions of Radicals

CHEMISTRY OF OXYGEN-DERIVED RADICALS

Historical Perspective

Definitions

One-Electron Reduction of Oxygen

Superoxide Radical Anion

Peroxyl Radicals

Hydroxyl Radical

CHEMISTRY OF ELECTRONICALLY EXCITED STATES

Singlet Oxygen

Excited Carbonyl Compounds

FORMATION OF REACTIVE OXYGEN METABOLITES IN VIVO

Introduction

Mitochondrial Electron Transport

Hemoproteins

Flavin-Linked Oxidases

The Microsomal Enzymme System

Phagocytosis

Electronically Excited Carbonyl

Compounds via Enzymatic Oxidations

Endothelium-Derived Relaxing Factor (EDRF)

REACTIONS OF REACTIVE OXYGEN METABOLITES WITH IMPORTANT BIOMOLECULES

General Remarks about Oxygen Radical Investigations

Reactions of Hydroxyl Radicals with Fatty Acids

Mechanism of Lipid Peroxidation-Induced Pathogenesis

Chemistry of Oxygen Radical Damage to DNA

DNA Damage via Electronically Excited States

Biological Markers for in vivo Oxidative Damage

NITRIC OXIDE

Chemical Formation of Nitric Oxide

Chemistry of Nitric Oxide

Important Reactions in the Deactivation of Nitric Oxide

Reactions of Nitrogen Dioxide

Nitric Oxide and Superoxide Dismutase

The Chemical Nature of EDRF

Chemistry of Peroxynitrite-Peroxynitrous Acid

The Role of Peroxzynitrite-Peroxynitrous Acid in vivo

Protective Effect of Nitric Oxide in Oxygen Radical Induced Damage

Toxicity of Nitric Oxide via Release of Fe(II) from Ferritin

Protein Derived Radicals and Nitric Oxide

ANTIOXIDANTS

Introduction

Superoxide Dismutases

Reactions of Oxygen and Oxygen Radicals with Ascorbic Acid

Uric Acid

Melatonin

Vitamin E

Antioxidan and Prooxidant Activity of Flavonoids

Carotenoids

Proteins which form Complexes with Transition-Metal Ions

Peptides as Antioxidants

Do Antioxidants Prevent Diseases in vivo?

PATHOLOGICAL PROCESSES INVOLVING REACTIVE OXYGEN METABOLITES

Introduction

Aging and Cancer

Inflammation, Cell Division, and Cancer

Neurodegenerative Disorders

Lung Diseases

Atherosclerosis

Ischemia-Reperfusion

Oxidative Stress and Lifestyle

CONCLUSION

REFERENCES

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI013040
SCIENCE / Chemistry / Organic