Reactive Oxygen Species in Biology and Human Health  book cover
1st Edition

Reactive Oxygen Species in Biology and Human Health

Edited By

Shamim I. Ahmad

ISBN 9781032339979
Published July 12, 2022 by CRC Press
584 Pages 32 Color & 73 B/W Illustrations

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Book Description

Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress.

Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders.

The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens.

Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.

Table of Contents


Introduction to Reactive Oxygen Species: Emphasizing Their Importance in the Male Reproductive System
Bongekile Skosana, Ibukun P. Oyeyipo, and Stefan S. Du Plessis

Detection of Reactive Oxygen Species
Oluwasesan Adegoke and Patricia B.C. Forbes

Ultraviolet Light, Chromophores, Reactive Oxygen Species, and Human Health
Shamim I. Ahmad

Ultraviolet A Radiation and ROS: Observations from Studies with Bacteria
Abraham Eisenstark and James Hoerter

ROS and Phenolic Compounds
Mario C. Foti and Riccardo Amorati

Lipoprotein-Associated Oxidative Stress
Ngoc-Anh Le


Role of Oxidative Damage in Neurodegeneration with Brain Iron Accumulation Disorders
Vincenzo Lupo, Alejandra Darling, Cristina Tello, Belén Pérez-Duenas, and Carmen Espinós


Reactive Oxygen Species in Amyotrophic Lateral Sclerosis
Finley J. Allgaier and J. Jefferson P. Perry

Alzheimer’s Disease, Oxidative Stress, and Neuroprotective Approaches
Anami Ahuja, Kapil Dev, and Pankaj K. Tyagi

Oxidative Stress and Mitochondrial Dysfunction in Huntington’s and Other Neurodegenerative Diseases
Abhishek Chandra and Ashu Johri

Free Radicals, Oxidative Stress, and Epilepsy
Jaroslava Folbergrová

Oxidative Stress and Neuropsychiatric Disorders in the Life Spectrum
Akihiko Nunomura, Toshio Tamaoki, Nobutaka Motohashi, Hyoung-gon Lee, Xiongwei Zhu, and George Perry

Reactive Oxygen Species and Antioxidant Therapies for Multiple Sclerosis Treatment
Elzbieta Miller, Dominika Ksiazek-Winiarek, Tomasz Wlodarczyk, and Andrzej Glabinski


Pulmonary Oxidant-Antioxidant Dysregulation in Asthma
Ahmed Nadeem, Ahmed M. El-Sherbeeny, Mohammed M. Al-Harbi, and Sheikh F. Ahmad

Smoking and ROS: Catalyst for Autoimmune Liver Diseases
Tanima Bose


Inflammation and Lung Cancer: Oxidative Stress, ROS, and DNA Damage
Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo, and Rui Medeiros

ROS and Breast Cancer
Lenora Ann Pluchino and Hwa-Chain Robert Wang

Reactive Oxygen Species and Redox Signaling in Breast Cancer
Carolina Panis, Bruno Ricardo Barreto Pires, Ana Carolina de Andrade, Mateus Batista Silva, and Vanessa Jacob Victorino

Reactive Oxygen Species in Melanoma Etiology
Feng Liu-Smith


Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Disease
Eric L. Johnson

Reactive Oxygen Species in the Cardiovascular System
Hiroaki Shimokawa and Kimio Satoh

Reactive Oxygen Species, Antioxidants, Inflammation, and Cardiovascular Disease
Harald Mangge and Johanna M. Gostner

Carotenoids, ROS, and Cardiovascular Health
Maria Alessandra Gammone


Oxidative Stress and Sickle Cell Disease
Danilo Grünig Humberto da Silva, Edis Belini Junior, Claudia Regina Bonini-Domingos, and Eduardo Alves de Almeida

Oxidative Stress in Nonalcoholic Steatohepatitis
Akinobu Takaki, Daisuke Uchida, and Kazuhide Yamamoto

Reactive Oxygen Species and Diabetic Retinopathy
Mohammad Shamsul Ola and Haseeb Ahsan

Reactive Oxygen Species: Physiology and Pathogenesis in Systemic Lupus Erythematosus
Ashish Aggrwal, Nidhi Mahajan, Mansoor Ali Syed, Bishnuhari Paudyal, Swapan K. Nath, and Dilip Shah

Oxidative Stress in Fibromyalgia Syndrome
Ghizal Fatima

Redox Mechanisms in Pulmonary Diseases
Li Zuo, Chia-Chen Chuang, and Tingyang Zhou

Pathological Effects of Elevated Reactive Oxygen Species on Sperm Function
Gulfam Ahmad and Ashok Agarwal

Reactive Oxygen Species and Male Fertility: The Physiological Role
Ibukun P. Oyeyipo, Bongekile Skosana, and Stefan S. Du Plessis

Impact of Oxidative Stress on DNA Damage in Human Spermatozoa
J.V. Villegas, P. Uribe, R. Boguen, and F. Treulen

Skin Aging, Reactive Oxygen Species, and Its Prevention
Vibha Rani

ROS and Ataxia Telangiectasia
Tetsuo Nakajima

Role of Oxidative Stress in RNA Virus-Induced Cell Death
Mohammad Latif Reshi and Jiann-Ruey Hong

Organophosphate-Induced Oxidative Stress and Neurotoxicity
Alan J. Hargreaves

Reactive Oxygen Species and Morphine Addiction
Zheng Qiusheng and Ma Jun

Exercise, Nitric Oxide, and ROS
Leonardo Y. Tanaka, Luiz Roberto G. Bechara, and Paulo R. Ramires

ROS and Epigenetics
Eric Hervouet, Jianhua Zhang, and Michaël Boyer-Guittaut

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Shamim I. Ahmad, after earning his master’s degree in botany from Patna University, Bihar, India, and his PhD in molecular genetics from the University of Leicester, England, joined Nottingham Polytechnic as a grade 1 lecturer and was subsequently promoted to the senior lecturer post. Nottingham Polytechnic subsequently became Nottingham Trent University, where, after serving for about 35 years, he took early retirement, yet continued serving as a part-time senior lecturer. Dr. Ahmad is now spending much of his time producing/writing medical books. His present interests include DNA damage and repair, specifically by near-ultraviolet light.