1st Edition

Reactive Oxygen Species in Biology and Human Health

Edited By Shamim I. Ahmad Copyright 2016
    584 Pages 32 Color & 73 B/W Illustrations
    by CRC Press

    567 Pages 32 Color & 73 B/W Illustrations
    by CRC Press

    567 Pages 32 Color & 73 B/W Illustrations
    by CRC Press

    Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress.

    Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders.

    The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens.

    Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.


    Introduction to Reactive Oxygen Species: Emphasizing Their Importance in the Male Reproductive System
    Bongekile Skosana, Ibukun P. Oyeyipo, and Stefan S. Du Plessis

    Detection of Reactive Oxygen Species
    Oluwasesan Adegoke and Patricia B.C. Forbes

    Ultraviolet Light, Chromophores, Reactive Oxygen Species, and Human Health
    Shamim I. Ahmad

    Ultraviolet A Radiation and ROS: Observations from Studies with Bacteria
    Abraham Eisenstark and James Hoerter

    ROS and Phenolic Compounds
    Mario C. Foti and Riccardo Amorati

    Lipoprotein-Associated Oxidative Stress
    Ngoc-Anh Le


    Role of Oxidative Damage in Neurodegeneration with Brain Iron Accumulation Disorders
    Vincenzo Lupo, Alejandra Darling, Cristina Tello, Belén Pérez-Duenas, and Carmen Espinós


    Reactive Oxygen Species in Amyotrophic Lateral Sclerosis
    Finley J. Allgaier and J. Jefferson P. Perry

    Alzheimer’s Disease, Oxidative Stress, and Neuroprotective Approaches
    Anami Ahuja, Kapil Dev, and Pankaj K. Tyagi

    Oxidative Stress and Mitochondrial Dysfunction in Huntington’s and Other Neurodegenerative Diseases
    Abhishek Chandra and Ashu Johri

    Free Radicals, Oxidative Stress, and Epilepsy
    Jaroslava Folbergrová

    Oxidative Stress and Neuropsychiatric Disorders in the Life Spectrum
    Akihiko Nunomura, Toshio Tamaoki, Nobutaka Motohashi, Hyoung-gon Lee, Xiongwei Zhu, and George Perry

    Reactive Oxygen Species and Antioxidant Therapies for Multiple Sclerosis Treatment
    Elzbieta Miller, Dominika Ksiazek-Winiarek, Tomasz Wlodarczyk, and Andrzej Glabinski


    Pulmonary Oxidant-Antioxidant Dysregulation in Asthma
    Ahmed Nadeem, Ahmed M. El-Sherbeeny, Mohammed M. Al-Harbi, and Sheikh F. Ahmad

    Smoking and ROS: Catalyst for Autoimmune Liver Diseases
    Tanima Bose


    Inflammation and Lung Cancer: Oxidative Stress, ROS, and DNA Damage
    Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo, and Rui Medeiros

    ROS and Breast Cancer
    Lenora Ann Pluchino and Hwa-Chain Robert Wang

    Reactive Oxygen Species and Redox Signaling in Breast Cancer
    Carolina Panis, Bruno Ricardo Barreto Pires, Ana Carolina de Andrade, Mateus Batista Silva, and Vanessa Jacob Victorino

    Reactive Oxygen Species in Melanoma Etiology
    Feng Liu-Smith


    Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Disease
    Eric L. Johnson

    Reactive Oxygen Species in the Cardiovascular System
    Hiroaki Shimokawa and Kimio Satoh

    Reactive Oxygen Species, Antioxidants, Inflammation, and Cardiovascular Disease
    Harald Mangge and Johanna M. Gostner

    Carotenoids, ROS, and Cardiovascular Health
    Maria Alessandra Gammone


    Oxidative Stress and Sickle Cell Disease
    Danilo Grünig Humberto da Silva, Edis Belini Junior, Claudia Regina Bonini-Domingos, and Eduardo Alves de Almeida

    Oxidative Stress in Nonalcoholic Steatohepatitis
    Akinobu Takaki, Daisuke Uchida, and Kazuhide Yamamoto

    Reactive Oxygen Species and Diabetic Retinopathy
    Mohammad Shamsul Ola and Haseeb Ahsan

    Reactive Oxygen Species: Physiology and Pathogenesis in Systemic Lupus Erythematosus
    Ashish Aggrwal, Nidhi Mahajan, Mansoor Ali Syed, Bishnuhari Paudyal, Swapan K. Nath, and Dilip Shah

    Oxidative Stress in Fibromyalgia Syndrome
    Ghizal Fatima

    Redox Mechanisms in Pulmonary Diseases
    Li Zuo, Chia-Chen Chuang, and Tingyang Zhou

    Pathological Effects of Elevated Reactive Oxygen Species on Sperm Function
    Gulfam Ahmad and Ashok Agarwal

    Reactive Oxygen Species and Male Fertility: The Physiological Role
    Ibukun P. Oyeyipo, Bongekile Skosana, and Stefan S. Du Plessis

    Impact of Oxidative Stress on DNA Damage in Human Spermatozoa
    J.V. Villegas, P. Uribe, R. Boguen, and F. Treulen

    Skin Aging, Reactive Oxygen Species, and Its Prevention
    Vibha Rani

    ROS and Ataxia Telangiectasia
    Tetsuo Nakajima

    Role of Oxidative Stress in RNA Virus-Induced Cell Death
    Mohammad Latif Reshi and Jiann-Ruey Hong

    Organophosphate-Induced Oxidative Stress and Neurotoxicity
    Alan J. Hargreaves

    Reactive Oxygen Species and Morphine Addiction
    Zheng Qiusheng and Ma Jun

    Exercise, Nitric Oxide, and ROS
    Leonardo Y. Tanaka, Luiz Roberto G. Bechara, and Paulo R. Ramires

    ROS and Epigenetics
    Eric Hervouet, Jianhua Zhang, and Michaël Boyer-Guittaut


    Shamim I. Ahmad, after earning his master’s degree in botany from Patna University, Bihar, India, and his PhD in molecular genetics from the University of Leicester, England, joined Nottingham Polytechnic as a grade 1 lecturer and was subsequently promoted to the senior lecturer post. Nottingham Polytechnic subsequently became Nottingham Trent University, where, after serving for about 35 years, he took early retirement, yet continued serving as a part-time senior lecturer. Dr. Ahmad is now spending much of his time producing/writing medical books. His present interests include DNA damage and repair, specifically by near-ultraviolet light.