1st Edition
Recent Advances in the Science of Cannabis
Recent Advances in the Science of Cannabis describes progress in a variety of significant areas of cannabis science. This unique book covers topics in cultivation and secondary metabolites, aroma and chemotypes, cannabinoid structures, physiology and pharmacology, as well as the development of unique topical products. State-of-the-art analytical methods and instrumentation are covered, including current developments in mass spectrometry and chromatography, as well as microbial testing. Given the popularity of smoking and vaporizing cannabis, the chemistry of vaping cannabinoid and terpene concentrates is also presented, along with emerging regulatory issues.
Key Features:
-
A guide to emerging modern cannabis technology in a dynamic regulatory climate and appealing to both novices and specialists.
- Building upon pioneering studies of terpene and cannabinoid chemistry, this distinctive volume describes current best practices, technological breakthroughs and historical context.
- Written by researchers in industry and academia, a greater understanding of the risks of exposure to emissions from vaping or dabbing cannabis concentrates is provided here.
- A selection of the book content reviewing Thermal Degradation of Cannabinoids and Cannabis Terpenes has been included in “Hot 2021” RSC Advances.
Contents
Preface......................................................................................................................vii
Editors........................................................................................................................ix
Contributors...............................................................................................................xi
Chapter 1 Cultivation Stress Techniques and the Production of Secondary
Metabolites in Cannabis sativa.............................................................1
Callie Seaman
Chapter 2 Aroma in Cannabis: A Foundation for Chemotype Classification..... 31
John S. Abrams, William J. T. Ellyson, Victor J. Gomez, and
Jean L. Talleyrand
Chapter 3 Cannabinoid Chemistry of Cannabis.................................................. 49
David Dawson and Markus Roggen
Chapter 4 Use of Mass Spectrometry for the Analysis of Cannabis
sativa spp......................................................................................... 79
Allegra Leghissa and Zacariah L. Hildenbrand
Chapter 5 New Trends in the Analysis of Cannabis-Based Products................ 111
Laura Mercolini, Roberto Mandrioli and Michele Protti
Chapter 6 Cannabis Microbial Testing: Methodologies and Considerations..... 131
Kyle Boyar
Chapter 7 Cannabis Extract Formulations and Devices.................................... 161
Brad Douglass and Robert M. Strongin
Chapter 8 Transdermal Delivery........................................................................ 193
Carolyn Burek, Jessica Painter, and Monica Vialpando
Chapter 9 Thermal Degradation of Cannabinoids and Cannabis Terpenes:
A Review........................................................................................... 215
Jiries Meehan-Atrash and Robert M. Strongin
Chapter 10 Cannabis Pharmacokinetics and Pharmacodynamics...................... 235
Ted W. Simon
Index....................................................................................................................... 267
Biography
Robert M. Strongin is a Professor of Organic Chemistry at Portland State University.
He has studied the chemistry of vaping since 2013. He has been interested in determining
how flavorings, including terpenes and other vape constituents, react and
degrade when heated and aerosolized. In 2017 he began to investigate cannabis vaping
and published the first peer-reviewed reports on the specific byproducts formed
when dabbing terpenes, and, more recently, on the reactions and products that form
upon vaping and dabbing concentrated cannabis oil mixtures. Dr. Strongin runs an
internationally recognized research program, is a founder of two biotech startup
companies, and is known for his contributions to STEM education. In addition to
tobacco control and cannabis science, he is an expert in the field of biosensors and
targeted molecular probes for imaging cancer tissue.
Monica Vialpando is a pharmaceutically trained product development scientist,
specializing in the formulation of poorly water-soluble drugs. As founder and CEO
of Via Innovations, a bespoke product development company, she integrates this
background with plant-based medicines to create fit-for-purpose designed products.
In addition to her entrepreneurial endeavors, she is active in education and thought
leadership and often focuses on cannabis-based strategies to support women’s health,
and is a scientific advisor to multiple organizations. With a passion for diversity and
global connection, Dr. Vialpando’s reach extends beyond typical barriers to collaborate
with international experts and companies. She also leverages this throughout
her company to design their differentiated products through the integration of plantbased
medicines, science, technology, and art.
Jiries Meehan-Atrash graduated from the State University of New York at New
Paltz with a Bachelor of Science in Chemistry in 2014 and in 2021 earned his PhD in
Chemistry from Portland State University after studying e-cigarette aerosol chemistry
and analytical methods under the mentorship of Dr. Robert M. Strongin. Jiries is
currently a postdoctoral fellow at the University of Rochester Medical Center in the
laboratory of Dr. Irfan Rahman.
