Receptor - Based Drug Design: 1st Edition (e-Book) book cover

Receptor - Based Drug Design

1st Edition

Edited by Paul Leff

CRC Press

400 pages

Purchasing Options:$ = USD
Hardback: 9780824701628
pub: 1998-04-10
eBook (VitalSource) : 9780429121326
pub: 1998-04-10
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Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.

Explains the experimental and theoretical methods used to characterize interactio

Table of Contents

Introduction, James Black

Principles and Measurement of Drug-Receptor Interactions

The Characterization and Classification of Receptors, Patrick P. A. Humphrey

Functional Methods for Quantifying Agonists and Antagonists, Iain G. Dougall

Quantification of Receptor Interactions Using Binding Methods, Sebastian Lazareno

Drug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors, T. Kendall Harden, Jose L. Boyer, and Robert W. Dougherty

The Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions, John G. Connolly and Charles Kennedy

Receptor-Based Drugs in Medicine

Selective Adrenergic and Glucocorticoid Treatments for Asthma, David Jack

Serotonin 5-HT1B/D Receptor Agonists, Graeme R. Martin

Histamine H2-Receptor Antagonists, Michael E. Parsons

Angiotensin Antagonists, Mark J. Robertson

Experimental and Emerging Drugs

-Adrenoceptor Agonists and Antagonists, J. Paul Hieble and Robert R. Ruffolo, Jr.

P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases, Eduardo R. Lazarowski, William C. Watt, T. Kendall Harden, and Richard C. Boucher

Muscarinic Receptor Antagonists Pharmacological and Therapeutic Utility, Richard M. Eglen

NMDA Receptor Antagonists, John A. Kemp and James N. C. Kew

New Trends in Drug Design

Computational Chemistry in Receptor-Based Drug Design, Ad P. IJzerman, Eleonora M. van der Wenden, and Wilma Kuipers

Recombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery, A. Donny Strosberg and Prabhavathi B. Fernandes

Inverse Agonists and G-Protein-Coupled Receptors, Richard A. Bond and Michel Bouvier

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Pharmacology