This book summarizes rapid progress and innovation in transplantation and regenerative medicine - the merger of reconstructive plastic surgery and transplantation - called Vascularized Composite Allotransplantation. This merger includes face, hand, uteri, larynx, tongue, penis and trachea translplantations as well as other body part transplants using grafts derived from organ donors. These sorts of transplants are now performed more commonly. Cell therapies for immunomodulation are surrogates for immune responses after transplantation to non-invasive imaging of neuroregeneration for improving functional outcomes after transplant.
Table of Contents
SECTION I: CELLULAR THERAPIES IN RECONSTRUCTIVE TRANSPLANTATION
1. Cell Therapies in Reconstructive Transplantation
Curtis L. Cetrulo, Jr., Amalya S. Wilson, Abraham Matar, Radbeh Torabi, Mohammadreza S. Pakyari, Elise Lupon, Marion Goutard, and Alexandre G. Lellouch
2. Novel T-Regulatory Cell-Based Therapies in Vascularized Composite Allotransplantation: Translational Implications
Yalcin Kulahci, Hulya Kapucu, James D. Fisher, and Steven R. Little
SECTION II: UNIQUE CONSIDERATIONS AND EMERGING INDICATIONS IN RECONSTRUCTIVE TRANSPLANTATION
3. Invasive and Non-Invasive Surrogates for Chronic Rejection in Vascularized Composite Allotransplantation: Claims and Controversies
Nicholas L. Robbins and Warren C. Breidenbach
4. Reperfusion Injury in Vascularized Composite Tissue Allografts: Impact on Graft Outcomes and Preventive Strategies
5. Pediatric Upper Extremity Vascularized Composite Allotransplantation: Progress and Insights
Kevin J. Zuo, Anna Gold, Randi Zlotnik Shaul, Emily S. Ho, Gregory H. Borschel, and Ronald M. Zuker
SECTION III: GRAFT MONITORING IN RECONSTRUCTIVE TRANSPLANTATION
6. Targeted Imaging and Therapeutic Technologies in Neuroregeneration
Jelena M. Janjic, Mihály Balogh, Sandeep Kumar Reddy Adena, Amanda Fitzpatrick, John A. Pollock, Vijay Gorantla, and Andrew J. Shepherd
7. Biomarkers and Surrogates of Acute Rejection in Vascularized Composite Allograft Transplantation
Calum Honeyman, Helen Stark, Hayson Chenyu Wang, Joanna Hester, Henk Giele, and Fadi Issa
SECTION IV: COMPOSITE TISSUE GRAFT MANIPULATION AND ENGINEERING
8. Bioengineering Composite Tissue Constructs: Concepts and Challenges
Kavit Amin, David Leonard, Li Yenn Yong, Ralph Murphy, Roxaana Moscalu, Kristen Liggat, and Jason Wong
9. Advances in Biomaterials for Reconstructive Transplantation
Ashish Dhayani and Praveen Kumar Vemula
10. Gene Editing Strategies for Immunomodulation: Translation from Cells to Vascularized Tissues
Fatih Zor, Esra Goktas, and Vijay Gorantla
Dr. Vijay Gorantla, MD, PhD, FRCS, is Professor of Surgery, Ophthalmology and Bioengineering and Director, Vascularized Composite Allotransplantation Program at the Atrium Health Wake Forest Baptist Medical Center, Winston Salem, North Carolina. Dr. Gorantla’s widely published expertise involves reconstructive transplantation after civilian or combat trauma with specific focus on graft targeted strategies for immune modulation, extended preservation, or non-invasive surveillance of these complex transplants.
Dr. Fatih Zor, MD, is Assistant Professor of Surgery at the Wake Forest Institute for Regenerative Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston Salem, North Carolina. Dr. Zor was recruited from the Gulhane Military Medical Academy in Turkey and holds a long-published track record with over 140 publications spanning clinical reconstructive surgery, microsurgery, and translational research in reconstructive transplantation.
Dr. Jelena M. Janjic, PhD, is Associate Professor of Pharmaceutics, at the Duquesne University School of Pharmacy, Pittsburgh, Pennsylvania. Dr. Janjic pioneered pain nanomedicine with distinguished expertise in theranostics, nanoimaging and targeted nanodrug delivery in inflammation, nerve regeneration, organ preservation and transplantation. Her research has led to multiple imaging technology patents and highlighted in over 50 publications including special journal issues and book chapters.