1st Edition

Rediscovering Cancer: From Mechanism to Therapy

Edited By Sayali Mukherjee, Somali Sanyal, Sonia Chadha Copyright 2018
    684 Pages 41 B/W Illustrations
    by Apple Academic Press

    684 Pages 41 B/W Illustrations
    by Apple Academic Press

    684 Pages 41 B/W Illustrations
    by Apple Academic Press

    This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.


    Genetic Instability in Cancer

    Gloria Ravegnini, Patrizia Hrelia, and Sabrina Angelini

    Oncogenesis and Telomerase Activity in Cancer

    Sutapa Mukherjee, Madhumita Roy, and Jaydip Biswas

    Cell Cycle Checkpoints in Cancer

    Sreeparna Chakraborty and Abhik Sen

    Angiogenesis, Its Importance and Implication in Tumor Growth and Progression and in Anticancer Therapy: An Update

    Chandrani Sarkar and Debanjan Chakroborty

    The Tumor Microenvironment and Metastasis

    Sonia Chadha

    Apoptosis: A Regulatory Mechanism in Cancer

    Sutapa Mukherjee, Apurba Mukherjee, Souvick Biswas, and Madhumita Roy

    Cytoplasmic Signaling Circuitry: An Important Trait of Cancer

    Subhra Dash, K. Lohitesh, and Sudeshna Mukherjee

    Cancer: An Overview of Risk Factors

    Sayali Mukherjee and Shabana Siddique

    Single Nucleotide Polymorphisms as Susceptibility Markers for Cancer

    Suresh Kumar Yadav and Somali Sanyal

    Dietary Phytochemicals in the Prevention and Therapy of Cancer: Modulation of Molecular Targets

    Shamee Bhattacharjee

    Health Benefits and Preventive Effects of Common Beverages in Cancer

    Vivek Kumar Gaur, Sanjay Gupta, and Janmejai Kumar Srivastava

    Cancer Chemotherapy

    Sonal Srivastava, Sakshi Mishra, Jayant Dewangan, Aman Divakar, Prabhash Kumar Pandey, and Srikanta Kumar Rath

    Non-Coding RNAs : The New Reins in Malignancies

    Deba Prasad Mandal

    Epigenetics in Cancer Prevention and Therapy: Role of Phytochemicals

    Sajid Khan, Samriddhi Shukla, and Syed Musthapa Meeran

    Cancer Stem Cell: Current Understanding and Future Perspectives

    Sonal Srivastava, Jayant Dewangan, Divya Tandon, and Srikanta Kumar Rath

    Tumor Microenvironment and Cancer Stem Cells: Therapeutic Potential of Epigenetic Inhibitors to Target CSCs

    Anup Kumar Singh, Priyank Chaturvedi, and Dipak Datta

    Nanoparticles in Cancer Therapy

    Madhuchanda Banerjee

    Cancer Immunotherapy: Extending New Horizons in Cancer Treatment

    Deba Prasad Mandal


    Sayali Mukherjee, PhD, is an Assistant Professor at the Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She completed her PhD from the Chittaranjan National Cancer Institute, Kolkata India, registered under Jadavpur University in Life Sciences. She received a NET-CSIR Research Fellowship. During her PhD she has worked on the toxicological and carcinogenic effects of air pollutants on human health. After completing her PhD, she has worked on stem cell culture as a Research Associate at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India. Presently she is working on immunological and biochemical aspects of oral cancer and oral diseases.

    Somali Sanyal, PhD, is an Assistant Professor at Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She received her PhD from the Karolinska Medical University, Stockholm, Sweden. During her PhD she has worked on molecular epidemiology of urinary bladder cancer. After her PhD she worked as a postdoctoral fellow at the Karolinska Medical University, Stockholm, Sweden. Later on she moved to the Central Drug Research Institute, Lucknow, India, as a Research Associate. Her current research focuses on genetic aspects of head and neck, oral, and gall bladder cancer. She has published several research articles in journals of national and international repute.

    Sonia Chadha, PhD, is presently working as a faculty member at the Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She completed her PhD from the Central Drug Research Institute, Lucknow, India, in biochemistry. During her PhD she has worked on the interaction of rat polymorphonuclear leukocyte derived free radical generation and nitric oxide in normal and in various pathological conditions. She has pursued her PDF from the National Environmental Engineering Research Institute (NEERI), Nagpur, India, where she worked on cytochrome P450. Her research interests include biochemical and molecular aspects of cancer and hypertensive disorders. She has several publications in national and international peer-reviewed journals.

    “One of the few books that sheds light on the causes and mechanisms of the disease itself as well as the possible therapeutic aspects. The book contains intricately woven chapters on cell cycle checkpoints on cancer, oncogenes, tumor suppressor genes, apoptosis, cell signaling, angiogenesis and metastasis. The modern approaches toward cancer diagnosis and therapy, like cancer stem cell, immunotherapy, chemotherapy, and nanoparticle-based therapy, have also been thoroughly covered. The contributors of each and every chapter are experts in their respective field and have summarized their research findings in a very concise manner. The best part of the book is that the chapters have been grouped into major divisions to have continuity and synchronization among them. The volume can be used by students and researchers who are working in the field of cancer. It covers new approaches toward cancer treatment and therefore may be useful handbook for clinicians. Overall, this informative volume covers the present knowledge and future direction on the field of cancer research.”

    — Dr. Naibedya Chattopadhyay, Scientist G, CSIR-Central Drug Research Institute, Lucknow, India