Redox Proteins in Supercomplexes and Signalosomes: 1st Edition (Hardback) book cover

Redox Proteins in Supercomplexes and Signalosomes

1st Edition

Edited by Ricardo O. Louro, Irene Diaz-Moreno

CRC Press

338 pages | 8 Color Illus. | 60 B/W Illus.

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Get Insight on the Function of Supercomplexes in Biological Systems

Redox Proteins in Supercomplexes and Signalosomes is one of the first books to explore the key role played by redox proteins and their interaction network in a wide range of essential cellular processes in all domains of life. The book explains how the mitochondrial respiratory chain is dynamically organized in supercomplexes even under physiological conditions. It also addresses the impact of supercomplex assembly on mitochondrial morphology, physiology, and biogenesis to shed light on the molecular mechanisms of pathological situations, including aging.

Discover the Connection between Bioenergetic Supercomplexes and Signalosomes

Compiling state-of-the-art research from leading practitioners in the field, this book gives you guidance on dealing with these biological systems in your investigations. The book shows that supercomplexes and signalosomes provide the link between reductive and systems biology, which enables us to understand how the molecular properties of individual macromolecular components trigger cellular function.


"This book covers perfectly the remarkable development and progress achieved in this multi-disciplinary field of modern biosciences. Thanks to the excellent selection of themes and well-recognized authors, it will be extremely useful for a broad scientific community. Clearly a book indispensable for both the expert as well as for the graduate student, bringing together the essential knowledge in a compact and up-to-date manner. The readers are introduced in a professional way to the exciting world of supercomplexes and signalosomes, which will enable them to grasp the state of the art and advancements in this rapidly developing research area."

—Peter M.H. Kroneck, Professor of Biochemistry, Department of Biology, University of Konstanz

Table of Contents

Multi-Electron Transfer in Biological Systems

Catarina M. Paquete, Bruno M. Fonseca, and Ricardo O. Louro

Diversity of Interactions in Redox Systems: From Short- to Long-Lived Complexes

Antonio Díaz-Quintana, IsabeL Cruz-Gallardo, Miguel A. De La Rosa, and Irene Díaz-Moreno

ATPases and Mitochondrial Supercomplexes

Sara Cogliati, Rebeca Acín-Pérez, and José A. Enriquez

Role of Cardiolipin in Mitochondrial Supercomplex Assembly

Eugenia Mileykovskaya and William Dowhan

Mitochondrial Supercomplexes and ROS Regulation: Implications for Ageing

Maria L. Genova and Giorgio Lenaz

Mitochondrial Respiratory Supercomplexes in Physiology and Diseases

Anna M. Ghelli, Valentina C. Tropeano, and Michela Rugolo

Regulation of Photosynthetic Electron Transport via Supercomplex Formation in the Thylakoid Membrane

Kentaro Ifuku and Toshiharu Shikanai

Microbial Redox Proteins and Protein Complexes for Extracellular Respiration

Liang Shi, Ming Tien, James K. Fredrickson, John M. Zachara, and Kevin M. Rosso

Unravelling New Metabolic Pathways: Supramolecular Organisation of Aerobic Bacteria Respiratory Chains

Ana M.P. Melo, Emma B. Gutiérrez-Cirlos, and Miguel Teixeira

Membrane Organisation and Electron Transport Switches in Cyanobacteria

Conrad W. Mullineaux and Tchern Lenn

Regulation of Cellular Signalling by Thioredoxin

Toshiya Machida, Hidenori Ichijo, and Isao Naguro

Cytochrome c–Based Signalosome

Katiuska González-Arzola, Blas Moreno-Beltrán, Jonathan Martínez-Fábregas, Miguel A. De La Rosa, and Irene Díaz-Moreno

Cell Membrane Raft Redox Signalosomes: Platform Responding to Danger Signals

Pin-Lan Li, Justine M. Abais, Jun-Xiang Bao, and Yang Zhang


Irene Díaz-Moreno and Ricardo O. Louro

About the Editors

Ricardo O. Louro is the leader of the Inorganic Biochemistry and NMR Laboratory at the Instituto de Tecnologia Química e Biológica (ITQB) António Xavier of the Universidade Nova de Lisboa. Dr. Louro is a member of the Portuguese Biochemical Society, the Society for Biological Inorganic Chemistry, and the International Society for Microbial Electrochemical Technologies. His research work focuses on the investigation of the molecular bases for biological electron-transfer phenomena relevant for bioenergetic processes and the applications of this knowledge to blue-, red- or white-biotechnology.

Irene Díaz-Moreno is an associate professor of biochemistry and molecular biology in the Instituto de Bioquímica Vegetal y Fotosíntesis (IBVF) at the Centro de Investigaciones Científicas Isla de la Cartuja (cicCartuja). Her past research has focused on molecular recognition between metalloproteins involved in electron-transfer processes and the regulatory mechanisms of mRNA decay by RNA-binding proteins. Dr. Díaz-Moreno is currently developing research projects in biointeractomics as well as on the posttranslational regulation of biological macromolecules.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Life Sciences / Cytology
SCIENCE / Physics