1st Edition

Regenerative Engineering

Edited By Cato T. Laurencin, Yusuf Khan Copyright 2013
    435 Pages 114 Color Illustrations
    by CRC Press

    436 Pages 114 Color Illustrations
    by CRC Press

    Distinct from tissue engineering, which focuses primarily on the repair of tissues, regenerative engineering focuses on the regeneration of tissues: creating living, functional tissue that has the ability to replace organs that are dysfunctional. The challenge of working in an area like regenerative engineering lies, in part, in the breadth of information required to truly appreciate and begin to think about this field. Regenerative Engineering introduces the field through the presentation of fundamental concepts of cell biology, stem cell science, materials science, and cell-material interactions. It also focuses on specific organ and tissue types and presents up-to-date examples of ongoing work, often in the context of a specific clinical need.

    Regenerative medicine focuses on the biological aspects of tissue regeneration via stem cells, factors, and cytokines, while tissue engineering focuses on the integration of materials science and life sciences. This book integrates these two areas, presenting each concept in the framework of regenerative engineering.


    • Covers a number of cutting-edge topics related to regenerative medicine and tissue engineering
    • Includes an introductory chapter on materials science
    • Features a number of the contributors who are world-class researchers, one of whom is Dr. Anthony Atala, whose work dealing with organ regenerative engineering was featured on Sixty Minutes
    • Incorporates problem-based learning throughout the text, which is not hypothetical but based on actual biological, engineering, or clinical scenarios

    Combining science, engineering and medicine, Regenerative Engineering incorporates all of the essential elements needed for further advancement in this field. The book explores the development and examination of vital organs and tissue types and addresses concerns as it relates to the regenerative engineering of various organ tissues, vascular tissues, bone, ligament, neural tissue, and the interfaces between tissues.

    Regenerative Engineering: The Future of Medicine

    Saadiq F. El-Amin III , MD , PhD; Joylene W.L. Thomas, MD ; Ugonna N. Ihekweazu, MD ; Mia D. Woods, MS; and Ashim Gupta, MS

    Cell Biology

    Gloria Gronowicz, PhD and Karen Sagomonyants, DMD

    Stem Cells and Tissue Regeneration

    Kristen Martins-Taylor, PhD; Xiaofang Wang, MD , PhD; Xue-Jun Li, PhD; and Ren-He Xu, MD , PhD

    Introduction to Materials Science

    Sangamesh G. Kumbar, PhD and Cato T. Laurencin, MD , PhD


    A. Jon Goldberg, PhD and Liisa T. Kuhn, PhD

    In Vitro Assessment of Cell–Biomaterial Interactions

    Yong Wang, PhD

    Host Response to Biomaterials and Its Implications in Regenerative Engineering

    Lakshmi S. Nair, MPhil, PhD

    Organ Regenerative Engineering: Cell Sources, Considerations, and Strategies

    Anthony Atala, MD; Meng Deng, PhD; and Yusuf Khan, PhD

    Cardiovascular Regenerative Engineering

    Rebekah A. Neal, PhD; Anusuya Das, PhD; and Edward A. Botchwey, PhD

    Bone Regenerative Engineering

    Yusuf Khan, PhD; Anil Magge, BS; and Cato T. Laurencin, MD , PhD

    Engineering Tissue-to-Tissue Interfaces

    Nancy M. Lee, ME ng; Nora T. Khanarian, PhD; Jung Hyun Park, PhD; and Helen H. Lu, PhD

    Neural Regenerative Engineering

    Shyam Aravamudhan, PhD and Ravi V. Bellamkonda, PhD

    Ligament Regenerative Engineering

    Parimala S. Samuel, MS; Benjamin R. Mintz, BS; Kristen L. Lee, BS; and James A. Cooper, Jr., PhD

    Skeletal Muscle Regenerative Engineering

    Shaun W. McLaughlin, BS; Michael N. Wosc zyna, PhD; Cato T. Laurencin, MD , PhD; and David J. Goldhamer, PhD

    Engineering Limb Regeneration: Lessons from Animals That Can Regenerate

    David M. Gardiner, PhD; Susan V. Bryant, PhD; and Ken Muneoka, PhD




    Cato T. Laurencin, MD, PhD, earned his BSE in chemical engineering from Princeton University, his PhD in biochemical engineering/biotechnology from the Massachusetts Institute of Technology, and his MD magna cum laude from Harvard Medical School. Dr. Laurencin is currently the chief executive officer of the Connecticut Institute for Clinical and Translational Science and director of the Institute for Regenerative Engineering at the University of Connecticut. He previously served as the vice president for health affairs and dean of the School of Medicine. He is a university professor and holds the Van Dusen Endowed Chair in the Department of Orthopaedic Surgery.

    Yusuf Khan, PhD, earned his master’s degree and PhD from Drexel University in biomedical engineering. He is currently an assistant professor at the Institute for Regenerative Engineering and the Department of Orthopaedic Surgery at the University of Connecticut Health Center. He has an appointment in the Department of Chemical, Materials, and Biomolecular Engineering and is part of the Department of Biomedical Engineering within the School of Engineering at the University of Connecticut. His research interests include musculoskeletal tissue regeneration using implantable biodegradable scaffolds, development of composite structures for bone regeneration, and the development of clinically relevant healing modalities using ultrasound.

    "This is a good book to have on your bookcase so that it can be easily handed to a student or young investigator. I foresee this book as a stepping off point to stimulate interest in a field that is rapidly evolving and is likely to have a significant impact on our ability to treat disease, disfigurement and trauma in the future."
    —Biomaterials Forum, Fourth Quarter 2013

    "This book gives historical precedence for tissue engineering while providing the most up-to-date clinical examples. It is nice to see tissue engineering strategies that are tissue-specific, as the design requirements of clinical solutions will depend largely on the tissue of interest. This book is ideal for introductory coursework or reference for the initiate in the field of tissue engineering. … The authors are leaders in their respective fields and have knowledge of both the breadth and depth of tissue engineering strategies. The text is well-organized and will fit well into most introductory biomaterials/tissue engineering courses around the country."
    —Laura Suggs, University of Texas at Austin, USA

    "The text is well written and succinct. The references are up to date. Given the background of the senior editor as an orthopaedic surgeon, clinical details are provided in most of the chapters in a highly readable manner, and this can be useful for the non-clinician user."
    —The Journal of Histotechnology, March 2014