1st Edition

Repeat Amino Acid Sequences in Proteins Biochemical and Medical Consequences

Edited By Vladimir N. Uversky, Munishwar Nath Gupta Copyright 2026
180 Pages 9 Color & 14 B/W Illustrations
by CRC Press

180 Pages 9 Color & 14 B/W Illustrations
by CRC Press

Repeat amino acid sequences are important in protein structure, disorder, function and evolution. Repeats of some amino acids exist in proteomes across species. This volume highlights: Which repeat sequences have pathogenic consequences and why? Repeats which lead to surface hydrophobic clusters and their importance Role of aromatic amino acid clusters in protein‐protein and... Read more

Preface

 

1. Pathogenic Role of Repeat Polypeptides in Repeat Expansion Diseases

Yuzo Fujino and Yoshitaka Nagai

 

2. Pathologies Due to PolyQ Sequences

Raffaella Parlato and Patrick C.A. van der Wel

 

3. Importance of Surface Hydrophobic Clusters in Proteins

Fabio C.L. Almeida, Ramon Pinheiro-Aguiar and Ariana Azevedo Vasconcelos

 

4. Residue Cluster Classes in Protein-Protein Interactions

Juan Martín Hernández Castillo, Albros Hermes Poot and Gabriel Del Río

 

5. Aromatic Clusters in Proteins: Folding, Drug Interactions and Protein-Protein Complexes

Esteban Lanzarotti, Lucas Defelipe, Marcelo Marti and Adrian Turjanski

 

6. Cell Penetrating Peptides with Repeat Sequences of Amino Acids

Ngoc Hai Trieu Phong, Mohammed A. Kamal, Duy Binh Tran and Tohru Yamada

 

7. Recent Advances and Applications in Self-Assembling Short-Chain Elastin-Like Peptide Analogs

Takeru Nose and Keitaro Suyama

 

Unconventional Fluorescence Properties of Non-aromatic Amino Acids: Material and

Biological Applications

Vishnu N. Vijayan, Karthika Kannan and Sushabhan Sadhukhan

 

Index

Biography

Vladimir N. Uversky B.S., M.S., Ph.D., D.Sc., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida. He has a Ph.D. in physics and mathematics from Moscow Institute of Physics and Technology was followed by a D.Sc. in biophysics from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences. He is a fellow of the Royal Society of Biology, the Royal Society of Chemistry, the American Institute for Medical and Biological Engineering, and the American Association for the Advancement of Science. He has authored over 1,350 scientific publications and edited several books and book series on protein structure, function, folding and misfolding. He has an h‐index of 133. He has collaborated with more than 12,500 colleagues from more than 2,750 research organizations in 89 countries/territories.

Munishwar Nath Gupta taught chemistry, biochemistry and biotechnology at IIT Delhi [1975‐2018]. He has a Ph.D. in biochemistry from IISc Bangalore was followed by post‐docs at the University of Minnesota, USA; MIT, USA; UTC, France and Lund University, Sweden. He is a fellow of NASI, Allahabad and INSA, New Delhi. He is currently Series Editor of Foundations and Frontiers in Enzymology, Elsevier. He has published over 300 scientific articles and edited 7 books so far. His current h‐index is 64.