1st Edition

Reproductive and Developmental Toxicology




ISBN 9780824798574
Published March 27, 1998 by CRC Press
740 Pages

USD $220.00

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Book Description

This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction.
Describing biological actions common to both genders as well as gender-specific processes, Reproductive and Developmental Toxicology

  • provides an overview of the basic biology and physiology of organ systems affected by toxicants
  • furnishes detailed examples of developmental toxicology
  • analyzes germ cell toxicity and infertility
  • covers the developmental effects of neurotoxicity
  • considers periods of exposure and long-term toxicological consequences
  • explains how gonadal processes may be susceptible to toxicants in other reproductive organ systems
  • and more!
    With over 3700 bibliographic citations and more than 100 photographs, drawings, and tables, Reproductive and Developmental Toxicology is a useful reference for toxicologists; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; obstetricians/gynecologists; pediatricians; pharmacists and pharmacologists; physiologists; geneticists; poison control specialists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
  • Table of Contents

    Development and Neurotoxicity

    Müllerian-Inhibiting Substance Activity and Normal Male Sex Determination, David T. MacLaughlin and Patricia K. Donahoe
    Effect of Environmental Chemicals on Early Development, Rama S. Dwivedi and Philip M. Iannaccone
    Developmental Toxicology, John M. Rogers and Robert J. Kavlock
    Malformations in Pregastrulation Developmental Toxicology, Joe C. Rutledge and Walderico M. Generoso
    Developmental Effects of Dioxins, Linda S. Birnbaum
    Transgenic and Knockout Mice: Genetic Models for Environmental Stress, Robert S. Tebbs, Jack B. Bishop, and Roger A. Pedersen
    Genes and Reproductive Behavior Resulting from Normal or Abnormal Development, Sonoko Ogawa and Donald W. Pfaff
    Reproductive Neuroendocrine Regulation in the Female: Toward a Neurochemical Mechanism for the Preovulatory Luteinizing Hormone Surge, William R. Crowley
    The Hypothalamus and Pituitary as Targets for Reproductive Toxicants, Ralph L. Cooper, Jerome M. Goldman, and Lee Tyrey
    Developmental Neurotoxicology, Gaylia Jean Harry
    Lead Neuroendocrine Toxicology, Rebecca Z. Sokol

    Female Reproduction

    Female Reproduction and Toxicology of Estrogens, James H. Clark
    Phytoestrogens and Reproductive Medicine, Claude L. Hughes, Jr., and Ginger Tansey
    Human Health and Phytoestrogens, Herman Adlercreutz Ovarian Toxicants: Multiple Mechanisms of Action, Barbara J. Davis and Jerrold J. Heindel
    Toxicology of Early Pregnancy, Implantation, and Uterine Function, Audrey M. Cummings
    TCDD and Uterine Function, Kimberly Silvers and Ellen A. Rorke
    Antiestrogenic Activity of TCDD and Related Compounds, Timothy Zacharewski and Stephen H. Safe
    Reproductive and Developmental Toxicity of Metals: Issues for Consideration in Human Health Risk Assessments, Rafael A. Ponce and Elaine M. Faustman

    Male Reproduction

    The Biology of the Male Reproductive Tract, Michael J. McPhaul
    Reciprocal Mesenchymal-Epithelial Interactions in Development of the Male Urogenital Tract, Gerald R. Cunha, Annemarie A. Donjacour, and Simon W. Hayward
    Influence of Estrogenic Agents on Mammalian Male Reproductive Tract Development, Retha R. Newbold
    Toxicity of the Male Excurrent Ducts and Accessory Sex Glands, Gary R. Klinefelter and Rex A. Hess
    Developmental Male Reproductive Toxicology of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and PCBs, Beth L. Roman and Richard E. Peterson
    Toxicity to Spermatogenesis and Its Detection, Richard M. Sharpe
    Gamete Toxicology: The Impact of New Technologies, Sally D. Perreault
    Sertoli Cell Toxicants, Ling-Hong Li and Jerrold J. Heindel

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    Reviews

    "
    …Dr. Kenneth Korach…deserves to be complemented for publishing an exhaustive and excellent volume. The book will certainly be a valuable addition to the libraries in academic and research institutions dealing with the field of toxicology and allied sciences.
    "-Indian Journal of Toxicology