Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1 : Regulating Mechanisms of Chemical Sensitivity book cover
1st Edition

Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1
Regulating Mechanisms of Chemical Sensitivity

ISBN 9781439813423
Published June 18, 2010 by CRC Press
594 Pages 208 B/W Illustrations

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Book Description

The clinical approaches to the chronic degenerative diseases that drain our resources, and compromise our well-being, have become almost exclusively symptom-focused. The common wisdom is that they are idiopathic with final outcomes to be managed rather than prevented or cured. That they are potentially reversible rarely enters into any discussion between doctor and patient.

A Homeostatic approach to Cure and Prevention for Researchers and Clinicians Working in Toxicology, Immunology, Neurology, and Internal Medicine

Reversibility of Chronic Degenerative Disease and Hypersensitivity, a four-part encyclopedia, offers a much different perspective on chronic degenerative disease, one that disputes the idiopathic label attached to most, as well as the usual fatalistic prognosis. The first volume, Regulating Mechanisms of Chemical Sensitivity, demonstrates that one aspect common to chronic diseases is the disruption of systemic and cellular homeostasis. Environmental pollutants play a large role, along with the contributions of genetic and life style factors, in disrupting the self-regulating mechanisms built into our normally adaptive cells.

"As dyshomeostasis develops in the nervous system, causes should be found and removed before the metabolicinduced tissue changes take place and cause autonomous, irreversible fixednamed diseases to occur. …Single and multiple chemicals in various doses either individually and/or in combinations can cause individual or multiorgan dysfunction of the endocrine system. The astute clinician must be aware of these factors in order to help the patient with hypersensitivity and/or chronic degenerative disease." Chapter 2

Drawing on a vast amount of data and clinical cases attended to by the authors in their own medical practices, this volume examines the complex relation that environmental pollution has with chronic degenerative diseases. It considers its impact on the body’s vast communication networks and what excessive overload does to homeostatic mechanisms.

The authors factor in both general and specific environmental loads and how they alter and trigger genetic and non-genetic responses. Volume 1 begins with an overview of the physiologic basis of homeostasis, exploring various ways that the body deals with toxins and the networks it uses to communicate news of assault and makes provisions for adaptation. The text delves into the connective tissue matrix and considers vascular, neural, endocrine, and immune system responses to a variety of noxious assaults.

"Both innate and acquired immunity can be and are altered in individuals with chemical sensitivity and chronic degenerative disease. …With pollutant overload changes can occur in the lymphatic channels, the lymph nodes, and lymph node egress as well as the lymphatic cells. Changes in mucosal function and the effects of the autonomic nervous system are evident with environmental pollutant overload." Chapter 3

Written by two very knowledgeable clinicians, it brings together research of the highest caliber and provides extensive discussions involving sophisticated biochemical, endocrine, and neural science. The text provides clinicians with the knowledge to understand the triggering and processes of degenerative diseases, so that they might develop more efficient treatment and prevention plans. The book also supplies the knowledge and perspective that can lead research to more effective treatments.

"The ground regulation system consisting of the connective tissue matrix, fibroblast, macrophages, mast cell, leukocyte, end capillary vessel and autonomic nerves, is a global information system for regulating the dynamics of homeostasis in the body. …One’s knowledge of this process must be the guide to move through the onset of early end-stage disease and, eventually, see the manifestations to fixed-named autonomous diseases. It is this knowledge that offers us the greatest potential … for preventing and reversing early homeostatic dysfunction." Chapter 1

Table of Contents

Chapter 1 The Physiologic Basis of Homeostasis
Overview of the Dynamics of Noxious Incitant Entry and Fate
  The Nature of the Incitant Stimulus
  The Nature of the Body’s Homeostatic Response
  The Nature of Information Intake and Distribution
  Automating the Body—Energy
  The Clinical Signs and Symptoms after Chronic Noxious Incitant Entry
The Body’s Communication System—The Ground Regulation System
   Anatomical Categories Used in Communication for Regulating Homeostatic Mechanism
   Skin and Mucous Membranes
    Connective Tissue Matrix
       Mechanical Support System (Support Structure)
       Communication System Properties
       Connective Tissue and Electromagnetic Energy
       Molecular Sieve
       Latent Free Radical Response
   Vascular Function—Homeostasis
     Vascular Sieve
     Vascular Tone
   Intravascular Content
     Plasma Proteins
     Plasma Lipids
     Neurological Aspects of Homeostasis
Pollutant Entry and the Body’s Homeostatic Response to and Fate of the Noxious Stimuli
   Total Environmental Load
   Total Body Load
   The Local Receptors
     Local Homeostatic Responses and Information Reception
     Matrix Receptor
   Adjustment Responses
     Local Cell and Matrix Reactions for the Adjustment Response
     Regional Homeostatic Adjustment
     Central Homeostasic Adjustment
     Principles and Facts about Adjustment Responses
   Defense System
     Redox System Latency
     The Early Defense Mechanism
     Tissue Response to Local Entry (Initially Sub Inflammatory)   
     Immune Response
     Nonimmune Detoxification in Relation to Homeostasis and the Defense Mechanism
   Repair Mechanism—Healing
     The Nonspecific Mesenchyme Reaction
     Rate of Enzyme and Nutrient Deficiency

Homeostatic Dysfunction Leading to a Disordered Homeostatic Response
   Periodic Response
   Aperiodic Response
The Specific Mechanisms of Inflammation and Function of Neutrophils and Macrophages
   Proinflammatory Cytokines
Neurological System Connection with the Connective Tissue Matrix and Inflammation


Chapter 2 Nervous System
   Linear and Biphasic Effects of Noxious Stimuli Entry
Autonomic Nervous System
   Anatomy and Physiology of the Peripheral Autonomic Nervous System
   Central Connection of the Autonomic Nervous System with the Hypothalamus
   Reflex Pathways
   Dysfunction of the Autonomic Nervous System
   Denervation Supersensitivity
   Law of Denervation
   Denervation and Spondylosis: Neuropathic Pain
   Neurally Mediated Hypotension and Tachycardia
   Neuromuscular Hypotension and Chronic Fatigue
   Reflex Sympathetic Dystrophy (Causalgia)
Pollutant Injury to the Eye
Pollutant Injury to the Nervous System of the Eye
Cranial Nerves
Autonomic Nerves
Neurogenic Vascular Responses to Pollutant Stimuli
Pathogenesis of Neuroimmunological Mediators (Neuropeptide Triggering by Noxious Stimuli)
The Acupuncture Energy Flow System (AES)
Voluntary Central Nervous System
Noxious Injury to the Blood-Brain Barrier
Noxious Injury after Penetration of the Blood-Brain Barrier
General Principles of Neuronal Physiology
Principles of Response after Toxic Exposure
Reversibility vs. Irreversibility of Cell Damage after Pollutant Exposure

Mechanism of Acute Central Nervous System Injury
Neurological Effects of Toxic Chemicals
Fixed-Named Disease
Toxic Neuropathy

Chapter 3 Immune System
Properties of Entering Noxious Excitants
   Stem Cells
Lymph Nodes, Lymphatic Organs, and the Lymphatic System
   Development of Lymphatic Channels and Lymphocytes
Regionalization of the Immune Response by Lymphatic Tissue Nodes and Channels after Mucosal Entry
   Mucosa Associated Lymphoid Tissue (MALT); Nasal   Associated Lymphoid Tissue (NALT); Bronchial Associated Lymphoid Tissue (BALT); Gut Associated Lymphoid Tissue (GALT)
Neuroimmune Regulation
The Clinical Implications of Food and Chemical Sensitivity in Relation to the Autonomic Nervous System and Immune System
   Innate Immunity
   Transition to Innate and Humoral Immunity in the Newborn and Infant
   Acquired Immunity
   The T-lymphocytes
   General Intrinsic Mechanisms
Onset of Antibodies
   Classes of Antibodies
   Inflammatory Effects
   Clinical Regulation of the Immune System
   The Cell Cycle
   Abnormal Cell Cycle Progression in Patients with Chronic    Fatigue Syndrome (CFS)
   Cell Cycle and Cancer
Failure of the Tolerance Mechanism Causes Autoimmune Diseases
Autogenous Lymphocytic Factor (ALF)
Cell Death
Allergy and Hypersensitivity
Aging and the Immune System

Chapter 4 Endocrine System
Integrated Physiology
Pituitary Gland
   Pollutant Effects on the Nervous System of the Pituitary Gland
   Pollutant Effects on the Physiology of the Pituitary
   Growth Hormone
Pineal Gland
Neuroendocrine System (Paraganglia, Paraneuron)
   Neuroendocrine Phenotype
   Biosynthetic Profile
     Secretory Granules
   Specialization of Neuroendocrine Cells
   Topography of Neuroendocrine Cell Subsets
   Branchiomeric Group
   Intravagal Neuroendocrine Cells
   Visceral-Autonomic Paraganglion Cells
   Genitourinary Paraganglion Cells
   Clinical Manifestations of Neuroendocrine Stimulation
Adrenal Glands
   Physiology of the Dynamics of Homeostasis and Dyshomeostasis in the Adrenal Glands
   Clinical Picture of Pollutant Injury and Adrenal Dysfunction
   Adrenal Insufficiency/Hypoadrenalism
Parathyroid Gland
   Organization/Activation Hypothesis
   Male Homosexuality
   Sexual Dysfunction
Uterus and Tubes
   Premenstrual Syndrome
   Vasculitis of the Reproductive System
   Spontaneous Abortion
   The Influence of Toxics on Hormonal Homeostasis
     Menopause Dysfunction
Vagina and Vulva
Testes and Seminal Vesicles
   Mechanisms of Action and Fetal Vulnerability
   Hormones and Neurobehavioral Effect
   Beyond Endocrine Disruption
     Implications and Ongoing Activities
   Exogenous Estrogens
   Estrogens in Milk
   Estrogenic Chemicals
   Sertoli Cell Number and Sperm Output
   Physiology and Pathophysiology
   Agents Acting Directly on the Thyroid

     Class I
     Class II
     Class III
     Class IV
     Class V

   Agents Acting Indirectly on the Thyroid
   General Properties, Distribution, and Epidemiology
     Sulfurated Organics Thiocyanate (SCN), Isothiocyanates, and Thioglycosides (Goitrin)
     Aliphatic Disulfides
     Phenolic and Phenolic-Carboxylic Derivatives
     Phthalate Esters and Phthalic Acid Derivatives: DHBAs
     PCBs and PBBs
     PAH, 3,4,-BaP, MCA, and 7,12-DMBA

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