1st Edition

Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1 Regulating Mechanisms of Chemical Sensitivity

By William J. Rea, Kalpana Patel Copyright 2010
    594 Pages 208 B/W Illustrations
    by CRC Press

    Volume I of a four volume set focuses on homeostasis and the scientific basis of pollutant invasion and reversal. Chapters explain previously misunderstood mechanisms of chronic disease and hypersensitivity involving core molecular function; the connective tissue matrix; the neurological, immune, and endocrine systems; ground regulation system; genetics; the autonomic nervous system; and immune and non-immune functions. It includes numerous color figures and abundant supporting research.

    Chapter 1 The Physiologic Basis of Homeostasis
    Overview of the Dynamics of Noxious Incitant Entry and Fate
      The Nature of the Incitant Stimulus
      The Nature of the Body’s Homeostatic Response
      The Nature of Information Intake and Distribution
      Automating the Body—Energy
      The Clinical Signs and Symptoms after Chronic Noxious Incitant Entry
    The Body’s Communication System—The Ground Regulation System
       Anatomical Categories Used in Communication for Regulating Homeostatic Mechanism
       Skin and Mucous Membranes
        Connective Tissue Matrix
           Mechanical Support System (Support Structure)
           Communication System Properties
           Connective Tissue and Electromagnetic Energy
           Molecular Sieve
           Latent Free Radical Response
       Vascular Function—Homeostasis
         Vascular Sieve
         Vascular Tone
       Intravascular Content
         Plasma Proteins
         Plasma Lipids
         Neurological Aspects of Homeostasis
    Pollutant Entry and the Body’s Homeostatic Response to and Fate of the Noxious Stimuli
       Total Environmental Load
       Total Body Load
       The Local Receptors
         Local Homeostatic Responses and Information Reception
         Matrix Receptor
       Adjustment Responses
         Local Cell and Matrix Reactions for the Adjustment Response
         Regional Homeostatic Adjustment
         Central Homeostasic Adjustment
         Principles and Facts about Adjustment Responses
       Defense System
         Redox System Latency
         The Early Defense Mechanism
         Tissue Response to Local Entry (Initially Sub Inflammatory)   
         Immune Response
         Nonimmune Detoxification in Relation to Homeostasis and the Defense Mechanism
       Repair Mechanism—Healing
         The Nonspecific Mesenchyme Reaction
         Rate of Enzyme and Nutrient Deficiency

    Homeostatic Dysfunction Leading to a Disordered Homeostatic Response
       Periodic Response
       Aperiodic Response
    The Specific Mechanisms of Inflammation and Function of Neutrophils and Macrophages
       Proinflammatory Cytokines
    Neurological System Connection with the Connective Tissue Matrix and Inflammation


    Chapter 2 Nervous System
       Linear and Biphasic Effects of Noxious Stimuli Entry
    Autonomic Nervous System
       Anatomy and Physiology of the Peripheral Autonomic Nervous System
       Central Connection of the Autonomic Nervous System with the Hypothalamus
       Reflex Pathways
       Dysfunction of the Autonomic Nervous System
       Denervation Supersensitivity
       Law of Denervation
       Denervation and Spondylosis: Neuropathic Pain
       Neurally Mediated Hypotension and Tachycardia
       Neuromuscular Hypotension and Chronic Fatigue
       Reflex Sympathetic Dystrophy (Causalgia)
    Pollutant Injury to the Eye
    Pollutant Injury to the Nervous System of the Eye
    Cranial Nerves
    Autonomic Nerves
    Neurogenic Vascular Responses to Pollutant Stimuli
    Pathogenesis of Neuroimmunological Mediators (Neuropeptide Triggering by Noxious Stimuli)
    The Acupuncture Energy Flow System (AES)
    Voluntary Central Nervous System
    Noxious Injury to the Blood-Brain Barrier
    Noxious Injury after Penetration of the Blood-Brain Barrier
    General Principles of Neuronal Physiology
    Principles of Response after Toxic Exposure
    Reversibility vs. Irreversibility of Cell Damage after Pollutant Exposure

    Mechanism of Acute Central Nervous System Injury
    Neurological Effects of Toxic Chemicals
    Fixed-Named Disease
    Toxic Neuropathy

    Chapter 3 Immune System
    Properties of Entering Noxious Excitants
       Stem Cells
    Lymph Nodes, Lymphatic Organs, and the Lymphatic System
       Development of Lymphatic Channels and Lymphocytes
    Regionalization of the Immune Response by Lymphatic Tissue Nodes and Channels after Mucosal Entry
       Mucosa Associated Lymphoid Tissue (MALT); Nasal   Associated Lymphoid Tissue (NALT); Bronchial Associated Lymphoid Tissue (BALT); Gut Associated Lymphoid Tissue (GALT)
    Neuroimmune Regulation
    The Clinical Implications of Food and Chemical Sensitivity in Relation to the Autonomic Nervous System and Immune System
       Innate Immunity
       Transition to Innate and Humoral Immunity in the Newborn and Infant
       Acquired Immunity
       The T-lymphocytes
       General Intrinsic Mechanisms
    Onset of Antibodies
       Classes of Antibodies
       Inflammatory Effects
       Clinical Regulation of the Immune System
       The Cell Cycle
       Abnormal Cell Cycle Progression in Patients with Chronic    Fatigue Syndrome (CFS)
       Cell Cycle and Cancer
    Failure of the Tolerance Mechanism Causes Autoimmune Diseases
    Autogenous Lymphocytic Factor (ALF)
    Cell Death
    Allergy and Hypersensitivity
    Aging and the Immune System

    Chapter 4 Endocrine System
    Integrated Physiology
    Pituitary Gland
       Pollutant Effects on the Nervous System of the Pituitary Gland
       Pollutant Effects on the Physiology of the Pituitary
       Growth Hormone
    Pineal Gland
    Neuroendocrine System (Paraganglia, Paraneuron)
       Neuroendocrine Phenotype
       Biosynthetic Profile
         Secretory Granules
       Specialization of Neuroendocrine Cells
       Topography of Neuroendocrine Cell Subsets
       Branchiomeric Group
       Intravagal Neuroendocrine Cells
       Visceral-Autonomic Paraganglion Cells
       Genitourinary Paraganglion Cells
       Clinical Manifestations of Neuroendocrine Stimulation
    Adrenal Glands
       Physiology of the Dynamics of Homeostasis and Dyshomeostasis in the Adrenal Glands
       Clinical Picture of Pollutant Injury and Adrenal Dysfunction
       Adrenal Insufficiency/Hypoadrenalism
    Parathyroid Gland
       Organization/Activation Hypothesis
       Male Homosexuality
       Sexual Dysfunction
    Uterus and Tubes
       Premenstrual Syndrome
       Vasculitis of the Reproductive System
       Spontaneous Abortion
       The Influence of Toxics on Hormonal Homeostasis
         Menopause Dysfunction
    Vagina and Vulva
    Testes and Seminal Vesicles
       Mechanisms of Action and Fetal Vulnerability
       Hormones and Neurobehavioral Effect
       Beyond Endocrine Disruption
         Implications and Ongoing Activities
       Exogenous Estrogens
       Estrogens in Milk
       Estrogenic Chemicals
       Sertoli Cell Number and Sperm Output
       Physiology and Pathophysiology
       Agents Acting Directly on the Thyroid

         Class I
         Class II
         Class III
         Class IV
         Class V

       Agents Acting Indirectly on the Thyroid
       General Properties, Distribution, and Epidemiology
         Sulfurated Organics Thiocyanate (SCN), Isothiocyanates, and Thioglycosides (Goitrin)
         Aliphatic Disulfides
         Phenolic and Phenolic-Carboxylic Derivatives
         Phthalate Esters and Phthalic Acid Derivatives: DHBAs
         PCBs and PBBs
         PAH, 3,4,-BaP, MCA, and 7,12-DMBA


    William J. Rea, Kalpana Patel