Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1: Regulating Mechanisms of Chemical Sensitivity, 1st Edition (Hardback) book cover

Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1

Regulating Mechanisms of Chemical Sensitivity, 1st Edition

By William J. Rea, Kalpana Patel

CRC Press

594 pages | 208 B/W Illus.

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Hardback: 9781439813423
pub: 2010-06-18
eBook (VitalSource) : 9780429191527
pub: 2010-06-18
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The clinical approaches to the chronic degenerative diseases that drain our resources, and compromise our well-being, have become almost exclusively symptom-focused. The common wisdom is that they are idiopathic with final outcomes to be managed rather than prevented or cured. That they are potentially reversible rarely enters into any discussion between doctor and patient.

A Homeostatic approach to Cure and Prevention for Researchers and Clinicians Working in Toxicology, Immunology, Neurology, and Internal Medicine

Reversibility of Chronic Degenerative Disease and Hypersensitivity, a four-part encyclopedia, offers a much different perspective on chronic degenerative disease, one that disputes the idiopathic label attached to most, as well as the usual fatalistic prognosis. The first volume, Regulating Mechanisms of Chemical Sensitivity, demonstrates that one aspect common to chronic diseases is the disruption of systemic and cellular homeostasis. Environmental pollutants play a large role, along with the contributions of genetic and life style factors, in disrupting the self-regulating mechanisms built into our normally adaptive cells.

"As dyshomeostasis develops in the nervous system, causes should be found and removed before the metabolicinduced tissue changes take place and cause autonomous, irreversible fixednamed diseases to occur. …Single and multiple chemicals in various doses either individually and/or in combinations can cause individual or multiorgan dysfunction of the endocrine system. The astute clinician must be aware of these factors in order to help the patient with hypersensitivity and/or chronic degenerative disease."Chapter 2

Drawing on a vast amount of data and clinical cases attended to by the authors in their own medical practices, this volume examines the complex relation that environmental pollution has with chronic degenerative diseases. It considers its impact on the body’s vast communication networks and what excessive overload does to homeostatic mechanisms.

The authors factor in both general and specific environmental loads and how they alter and trigger genetic and non-genetic responses. Volume 1 begins with an overview of the physiologic basis of homeostasis, exploring various ways that the body deals with toxins and the networks it uses to communicate news of assault and makes provisions for adaptation. The text delves into the connective tissue matrix and considers vascular, neural, endocrine, and immune system responses to a variety of noxious assaults.

"Both innate and acquired immunity can be and are altered in individuals with chemical sensitivity and chronic degenerative disease. …With pollutant overload changes can occur in the lymphatic channels, the lymph nodes, and lymph node egress as well as the lymphatic cells. Changes in mucosal function and the effects of the autonomic nervous system are evident with environmental pollutant overload." Chapter 3

Written by two very knowledgeable clinicians, it brings together research of the highest caliber and provides extensive discussions involving sophisticated biochemical, endocrine, and neural science. The text provides clinicians with the knowledge to understand the triggering and processes of degenerative diseases, so that they might develop more efficient treatment and prevention plans. The book also supplies the knowledge and perspective that can lead research to more effective treatments.

"The ground regulation system consisting of the connective tissue matrix, fibroblast, macrophages, mast cell, leukocyte, end capillary vessel and autonomic nerves, is a global information system for regulating the dynamics of homeostasis in the body. …One’s knowledge of this process must be the guide to move through the onset of early end-stage disease and, eventually, see the manifestations to fixed-named autonomous diseases. It is this knowledge that offers us the greatest potential … for preventing and reversing early homeostatic dysfunction." Chapter 1

Table of Contents

Chapter 1 The Physiologic Basis of Homeostasis


Overview of the Dynamics of Noxious Incitant Entry and Fate

The Nature of the Incitant Stimulus

The Nature of the Body’s Homeostatic Response

The Nature of Information Intake and Distribution

Automating the Body—Energy

The Clinical Signs and Symptoms after Chronic Noxious Incitant Entry

The Body’s Communication System—The Ground Regulation System

Anatomical Categories Used in Communication for Regulating Homeostatic Mechanism

Skin and Mucous Membranes

Connective Tissue Matrix

Mechanical Support System (Support Structure)

Communication System Properties

Connective Tissue and Electromagnetic Energy

Molecular Sieve

Latent Free Radical Response

Vascular Function—Homeostasis


Vascular Sieve


Vascular Tone


Intravascular Content


Plasma Proteins

Plasma Lipids

Neurological Aspects of Homeostasis

Pollutant Entry and the Body’s Homeostatic Response to and Fate of the Noxious Stimuli

Total Environmental Load

Total Body Load

The Local Receptors

Local Homeostatic Responses and Information Reception

Matrix Receptor

Adjustment Responses

Local Cell and Matrix Reactions for the Adjustment Response

Regional Homeostatic Adjustment

Central Homeostasic Adjustment

Principles and Facts about Adjustment Responses

Defense System

Redox System Latency

The Early Defense Mechanism

Tissue Response to Local Entry (Initially Sub Inflammatory)

Immune Response

Nonimmune Detoxification in Relation to Homeostasis and the Defense Mechanism

Repair Mechanism—Healing

The Nonspecific Mesenchyme Reaction

Rate of Enzyme and Nutrient Deficiency

Homeostatic Dysfunction Leading to a Disordered Homeostatic Response

Periodic Response

Aperiodic Response

The Specific Mechanisms of Inflammation and Function of Neutrophils and Macrophages

Proinflammatory Cytokines


Neurological System Connection with the Connective Tissue Matrix and Inflammation




Chapter 2 Nervous System


Linear and Biphasic Effects of Noxious Stimuli Entry


Autonomic Nervous System

Anatomy and Physiology of the Peripheral Autonomic Nervous System

Central Connection of the Autonomic Nervous System with the Hypothalamus

Reflex Pathways

Dysfunction of the Autonomic Nervous System

Denervation Supersensitivity

Law of Denervation

Denervation and Spondylosis: Neuropathic Pain

Neurally Mediated Hypotension and Tachycardia

Neuromuscular Hypotension and Chronic Fatigue

Reflex Sympathetic Dystrophy (Causalgia)

Pollutant Injury to the Eye

Pollutant Injury to the Nervous System of the Eye

Cranial Nerves

Autonomic Nerves

Neurogenic Vascular Responses to Pollutant Stimuli

Pathogenesis of Neuroimmunological Mediators (Neuropeptide Triggering by Noxious Stimuli)

The Acupuncture Energy Flow System (AES)


Voluntary Central Nervous System

Noxious Injury to the Blood-Brain Barrier

Noxious Injury after Penetration of the Blood-Brain Barrier

General Principles of Neuronal Physiology

Principles of Response after Toxic Exposure

Reversibility vs. Irreversibility of Cell Damage after Pollutant Exposure

Mechanism of Acute Central Nervous System Injury

Neurological Effects of Toxic Chemicals

Fixed-Named Disease

Toxic Neuropathy



Chapter 3 Immune System


Properties of Entering Noxious Excitants

Stem Cells

Lymph Nodes, Lymphatic Organs, and the Lymphatic System

Development of Lymphatic Channels and Lymphocytes

Regionalization of the Immune Response by Lymphatic Tissue Nodes and Channels after Mucosal Entry

Mucosa Associated Lymphoid Tissue (MALT); Nasal Associated Lymphoid Tissue (NALT); Bronchial Associated Lymphoid Tissue (BALT); Gut Associated Lymphoid Tissue (GALT)

Neuroimmune Regulation

The Clinical Implications of Food and Chemical Sensitivity in Relation to the Autonomic Nervous System and Immune System


Innate Immunity

Transition to Innate and Humoral Immunity in the Newborn and Infant

Acquired Immunity


The T-lymphocytes

General Intrinsic Mechanisms


Onset of Antibodies

Classes of Antibodies

Inflammatory Effects

Clinical Regulation of the Immune System

The Cell Cycle

Abnormal Cell Cycle Progression in Patients with Chronic Fatigue Syndrome (CFS)

Cell Cycle and Cancer


Failure of the Tolerance Mechanism Causes Autoimmune Diseases

Autogenous Lymphocytic Factor (ALF)

Cell Death

Allergy and Hypersensitivity

Aging and the Immune System



Chapter 4 Endocrine System


Integrated Physiology

Pituitary Gland

Pollutant Effects on the Nervous System of the Pituitary Gland

Pollutant Effects on the Physiology of the Pituitary

Growth Hormone

Pineal Gland

Neuroendocrine System (Paraganglia, Paraneuron)

Neuroendocrine Phenotype

Biosynthetic Profile

Secretory Granules

Specialization of Neuroendocrine Cells

Topography of Neuroendocrine Cell Subsets

Branchiomeric Group

Intravagal Neuroendocrine Cells

Visceral-Autonomic Paraganglion Cells

Genitourinary Paraganglion Cells


Clinical Manifestations of Neuroendocrine Stimulation

Adrenal Glands

Physiology of the Dynamics of Homeostasis and Dyshomeostasis in the Adrenal Glands

Clinical Picture of Pollutant Injury and Adrenal Dysfunction


Adrenal Insufficiency/Hypoadrenalism

Parathyroid Gland


Organization/Activation Hypothesis

Male Homosexuality

Sexual Dysfunction

Uterus and Tubes

Premenstrual Syndrome

Vasculitis of the Reproductive System


Spontaneous Abortion


The Influence of Toxics on Hormonal Homeostasis



Menopause Dysfunction

Vagina and Vulva

Testes and Seminal Vesicles

Mechanisms of Action and Fetal Vulnerability

Hormones and Neurobehavioral Effect

Beyond Endocrine Disruption

Implications and Ongoing Activities

Exogenous Estrogens


Estrogens in Milk

Estrogenic Chemicals

Sertoli Cell Number and Sperm Output


Physiology and Pathophysiology

Agents Acting Directly on the Thyroid

Class I

Class II

Class III

Class IV

Class V

Agents Acting Indirectly on the Thyroid

General Properties, Distribution, and Epidemiology

Sulfurated Organics Thiocyanate (SCN), Isothiocyanates, and Thioglycosides (Goitrin)

Aliphatic Disulfides


Phenolic and Phenolic-Carboxylic Derivatives


Phthalate Esters and Phthalic Acid Derivatives: DHBAs

PCBs and PBBs

PAH, 3,4,-BaP, MCA, and 7,12-DMBA



Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Internal Medicine
MEDICAL / Pulmonary & Thoracic Medicine
MEDICAL / Toxicology
SCIENCE / Chemistry / General
SCIENCE / Environmental Science