1st Edition

Revival: Glutathione (1990)

ISBN 9781138558939
Published January 28, 2019 by CRC Press
392 Pages

USD $120.00

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Book Description

This important book is to present the reader with developments concerning glutathione research. This work focuses on the synthesis-degradation and oxidation-reduction cycles of glutathione, the physiological functions of glutathione (especially in mammalian cells), and the analytical methods used to accurately measure the glutathione status of cells. This resource addresses specific modification of glutathione metabolism that is of special interest in the treatment of some tumors. This rare volume also introduces some different, new techniques on how to accurately measure glutathione, specifically in its oxidized form. Anyone involved with biochemistry, physiology, toxicology, pharmacology, nutrition and radiation biology will find this publication interesting and filled with useful information. It is also a valuable reference for research scientists in such fields as aging, metabolism disorders, and glutathione research.

Table of Contents

1. Publications on Glutathione, 1983-1987, A Bibliometric Study  2. Determination of Tissue Glutathione  3. Manipulation of Liver Glutathione Status-A Double-Edged Sword  4. Compartmentation of Cellular Glutathione in Mitochondrial and Cytosolic Pools  5. Hormonal Influence of GSH Content in Isolated Hepatocytes  6. Glutathione Transport and Its Significance in Oxidative Stress  7. Glutathione and Alcohol. Glutathione in Prokaryotes  8. Biosynthesis and Regulation of g-Glutamyl Transpeptidase  9. The Role of g-Glutamyl Transpeptidase (g GTPase) in Mammary Tissue  10. Structure, Mechanism, Functions, and Regulatory Properties of Glutathione Reductase  11. Glutathione Transferase in Human Tumors and Human Cancer Cell Lines  12. The Formation of Disulphide Bonds in the Synthesis of Secretory Proteins: Properties and Role of Protein Disulfide-Isomerase  13. The Glyoxalase System: Towards Functional Characterization and a Role in Disease Processes  14. Glutaredoxin: Structure and Function 15. Glutathione and Protein Function  16. Role of Glutathione in the Regulation of Protein Synthesis and Degradation in Eukaryotes  17. Aging and Increased Oxidation of the Sulfur Pool  18. Glutathione Metabolism in the Mammalian Ocular Lens  19. Role of Glutathione in the Aging Process of the Lens  20. Renal Handling of Glutathione  21. Glutathione in Ischemia and Reperfusion-Induced Tissue Injury  22. Free Radicals and Thiol Compounds (The Role of Glutathione against Free Radical Toxicity)  23. N-Acetylcysteine Stereoisomers as in vivo Probes of the Role of Glutathione in Drug Detoxification  24. Glutathione Levels in Human Hepatocytes Exposed to Paracetamol  25. Biological Implications of the Nucleophilic Addition of Glutathione to Quinoid Compounds  26. Glutathione and Hepatobiliary Transport of Xenobiotics  27. The Role of Glutathione in the Enzymatic Deiodination of Thyroid Hormone  28. Glutathione in Pineal Mechanisms and Functions  29. Nutritional Significance of Glutathione  30. The Potential Benefits of Dietary Glutathione on Immune Function and Other Practical Implications  31. Hereditary Disorders in Glutathione Metabolism.

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Jose Vina is Professor of Physiology at the University of Valencia.