This important book is to present the reader with developments concerning glutathione research. This work focuses on the synthesis-degradation and oxidation-reduction cycles of glutathione, the physiological functions of glutathione (especially in mammalian cells), and the analytical methods used to accurately measure the glutathione status of cells. This resource addresses specific modification of glutathione metabolism that is of special interest in the treatment of some tumors. This rare volume also introduces some different, new techniques on how to accurately measure glutathione, specifically in its oxidized form. Anyone involved with biochemistry, physiology, toxicology, pharmacology, nutrition and radiation biology will find this publication interesting and filled with useful information. It is also a valuable reference for research scientists in such fields as aging, metabolism disorders, and glutathione research.
Table of Contents
1. Publications on Glutathione, 1983-1987, A Bibliometric Study 2. Determination of Tissue Glutathione 3. Manipulation of Liver Glutathione Status-A Double-Edged Sword 4. Compartmentation of Cellular Glutathione in Mitochondrial and Cytosolic Pools 5. Hormonal Influence of GSH Content in Isolated Hepatocytes 6. Glutathione Transport and Its Significance in Oxidative Stress 7. Glutathione and Alcohol. Glutathione in Prokaryotes 8. Biosynthesis and Regulation of g-Glutamyl Transpeptidase 9. The Role of g-Glutamyl Transpeptidase (g GTPase) in Mammary Tissue 10. Structure, Mechanism, Functions, and Regulatory Properties of Glutathione Reductase 11. Glutathione Transferase in Human Tumors and Human Cancer Cell Lines 12. The Formation of Disulphide Bonds in the Synthesis of Secretory Proteins: Properties and Role of Protein Disulfide-Isomerase 13. The Glyoxalase System: Towards Functional Characterization and a Role in Disease Processes 14. Glutaredoxin: Structure and Function 15. Glutathione and Protein Function 16. Role of Glutathione in the Regulation of Protein Synthesis and Degradation in Eukaryotes 17. Aging and Increased Oxidation of the Sulfur Pool 18. Glutathione Metabolism in the Mammalian Ocular Lens 19. Role of Glutathione in the Aging Process of the Lens 20. Renal Handling of Glutathione 21. Glutathione in Ischemia and Reperfusion-Induced Tissue Injury 22. Free Radicals and Thiol Compounds (The Role of Glutathione against Free Radical Toxicity) 23. N-Acetylcysteine Stereoisomers as in vivo Probes of the Role of Glutathione in Drug Detoxification 24. Glutathione Levels in Human Hepatocytes Exposed to Paracetamol 25. Biological Implications of the Nucleophilic Addition of Glutathione to Quinoid Compounds 26. Glutathione and Hepatobiliary Transport of Xenobiotics 27. The Role of Glutathione in the Enzymatic Deiodination of Thyroid Hormone 28. Glutathione in Pineal Mechanisms and Functions 29. Nutritional Significance of Glutathione 30. The Potential Benefits of Dietary Glutathione on Immune Function and Other Practical Implications 31. Hereditary Disorders in Glutathione Metabolism.
Jose Vina is Professor of Physiology at the University of Valencia.