1st Edition

Revival: Hepatocyte and Kupffer Cell Interactions (1992)

Edited By Timothy R. Billiar, Ronald D. Curran Copyright 1992
    310 Pages
    by CRC Press

    310 Pages
    by CRC Press

    Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states.
    Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.

    Section 1 - The Normal Liver:

    1. The Origin of Kupffer Cells and Their Anatomic Relationship to Hepatocytes

    L. Bouwens and E. Wisse

    2. Modes of Communication between Kupffer Cells and Hepatocytes Under Normal and Pathological Conditions

    (T.C. Peterson

    3. Experimental Models for Studying the Interaction of Kupffer Cells and Hepatocytes

    B.G. Harbrecht, T.R. Billiar, and R.D. Curran

    Section 2 - Nonseptic pathologic States:

    4. Antitumor Defense System of the Liver

    S.-P. Tzung and S.A. Cohen

    5. Alcohol-Induced Liver Disease

    S.N. Wickremasinghe

    6. Viral Infections and Hepatitis

    D. Vetter, A. Kirn, and J.-P. Gut

    7. Role of Macrophages and Endothelial Cells in Hepatotoxicity

    D.L. Laskin

    8. Liver Alloimmunity

    G.L. Bumgardner and P. S. Almond

    9. Nonparenchymal Cell and Hepatocyte Interaction in Antimalarial Activity: A Central Role for Nitric Oxide

    A.K. Nussler

    Section 3 - The Liver in Sepsis:

    10. Regulation of Kupffer Cell Activation

    M.A. West and M.L. Heaney

    11. The Role of Kupffer Cells in Control of Acute Phase Protein Synthesis

    P.H. Kispert

    12. The Changes in Hepatic Lipid and Carbohydrate Metabolism in Sepsis

    T.W. Lysz and G.W. Machiedo


    Timothy R. Billiar, M.D., has served as the George Vance Foster Professor and Chair in the Department of Surgery at the University of Pittsburgh School of Medicine since 1999. Dr. Billiar completed his surgical residency at the University of Minnesota and the University of Pittsburgh. Dr. Billiar's research has also been recognized with membership in the Institute of Medicine and the National Academy of Sciences.


    BA Natural Sciences, Doane College, NE

    MD Medicine, University of Chicago, Pritzker School of Medicine

    Dr. Curran graduated from the Rush Medical College in 1984. He works in Chicago, IL and specializes in Cardiovascular Disease and General Surgery . Dr. Curran is affiliated with Swedish Covenant Hospital. He speaks English and Korean.

    Education & Training

    Medical School: graduated from the Rush Medical College

    Graduation Date: in 1984.

    Specialties & Hospital Affiliations

    Hospital Affiliations: Swedish Covenant Hospital

    Specialties: Cardiovascular Disease and General Surgery