Intended for cell biologists, biophysicists, biochemists, molecular biologists, physiologists, researchers in hemostatsis and thrombosis and pathologists, this book provides an insight into cell adhesion from three interdisciplinary perspectives: fundamental facts of adhesion; molecular biochemistry of adhesion and physiological aspects. It summarizes the basic aspects of surfaces in general and describes the theoretical and experimental tools necessary to investigate cell adhesion, including the basic biochemistry and molecular biology of adhesion. The book offers concise treatment of individual topics, features current material, and provides key references as a guide to further study.
Table of Contents
SECTION I: Fundamental Facets of Adhesion 1. Physical and Molecular Biochemical Aspects of Cell Adhesion: Viewpoints Approaching a Mutual Understanding Peter D. Richardson 2. Biomechanics and Thermodynamics of Cell Adhesion Cheng Zhu 3. Influences of Surface Chemical Factors on Selective Cellular Retention Robert E. Baier, Karen H. Rittle, and Anne E. Meyer 4. Dictyostelium discoideum Cohesion and Adhesion Donna R. Fontana 5. Adhesive Properties of Bacteria Josef Beuth and Gerhard Uhlenbruck 6. Bioadhesives: DOPA and Phenolic Proteins as Components of Organic Composite Materials Leszek M. Rzepecki, Karolyn M. Hansen, and J. Herbert Waite 7. Flow Effects on Leukocyte Adhesion to Vascular Endothelium Divid A. Jones, C. Wayne Smith, and Larry V. McIntire SECTION II: The Molecular Biochemistry of Adhesion 8. The Integrin Cell Adhesion Molecules Jonathan M. Edelman, Paul A. DiMilla, and Steven M. Albelda 9. The Structure and Biological Function of the Neural Cell Adhesion Molecule N-CAM John J. Hemperly 10. The Selectin Family of Adhesion Molecules Eric Larsen 11. Structure and Assembly of Basement Membrane and Related Extracellular Matrix Konrad Beck and Tanja Gruber 12. The Interaction of the Cytoskeleton with Adhesive Receptors: Effects on Cell Adhesion Joan E. B. Fox SECTION III: Physiology of Adhesion 13. Homing of Cells: Stem Cell as a Model Mehdi Tavassoli (Posthumous) 14. Platelet Aggregation and Inhibitors Kailash C. Agarwal 15. Platelet Adhesion Manfred Steiner 16. Interactions Among Platelets, Tumor Cells, and the Vessel Wall Kenneth V. Honn, Yong Q. Chen, and Dean G. Tang 17. Pharmacological Intervention of Platelet Adhesion Doloretta Dawicki 18. Platelet Adhesion to Damaged Vessel Wall S. Fazal Mohammad Index
Peter D. Richardson, Ph.D., D.Sc.(Eng.), D.Sc., F.R.S., received his B.Sc. in engineering from the Imperial Collect of Science, Technology and Medicine of the University of London in 1955, and his Ph.D. from the same institution in 1958. Immediately afterward he joined Brown University, where he has been a professor of engineering since 1968 and professor of engineering and physiology since 1984. He is the author or co-author of more than 180 scientific and engineering publications.
Manfred Steiner, M.D., Ph.D., received his M.D. from the University of Vienna in 1955 and his Ph.D. in biochemistry from the Massachusetts Institute of Technology in 1967. He joined Brown University in 1968 as an assistant professor, became an associate professor in 1972 and professor of medicine in 1978. In 1982 he was appointed section leader of the Division of Hematology, Brown University, and Director, Division of Hematology/Oncology at Memorial Hospital of Rhode Island. Dr. Steiner is author or co-author of more than 150 research papers and book chapters, most regarding the subject of platelet function.