Revival: The FOS and JUN Families of Transcription Factors (1994): 1st Edition (Paperback) book cover

Revival: The FOS and JUN Families of Transcription Factors (1994)

1st Edition

By Peter E. Angel, Peter Herrlich

CRC Press

322 pages

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This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.

Table of Contents

Characteristics of AP-1 Subunits

Jun Family, Angel and Herrlich

FOS Family, Schuermann

Regulation of AP-1 Activity and Synthesis

Protein/Protein Interactions: Factors Modulating AP-1 Activity, Sassone-Corsi

Steroid Hormone Receptors/AP-1, Cato

Post-Translational Modification: Jun Modification, Sachsenmaier and Radler-Pohl

FOS Modification, Shaw

Nuclear Uptake, Jeanteur

Promoter Regulation: C-FOS, Nordheim

C-Jun, Mechta and Yaniv

Functions in Physiological Processes

AP-1 Regulated Target Genes, Busslinger

Neural Cell Function, Sassone-Corsi

Differentiation, Rüther

Stress Response, Rahmsdorf

Functions in Pathology

FOS and Jun Oncogenes: FOS in Transformation, Müller

Jun in Transformation, Vogt

Oncogenes Acting through FOS and Jun: Raf Kinase, Rapp

Other Oncogenes, Schönthal

Adenovirus E1A/AP-1 Connection, van Dam and van der Eb

Tumor Promotion and Carcinogenesis, Yuspa

Tumor Progression, Hart

About the Series

CRC Press Revivals

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry