Role of Cancer Stem Cells in Cancer Biology and Therapy: 1st Edition (Hardback) book cover

Role of Cancer Stem Cells in Cancer Biology and Therapy

1st Edition

Edited by Thomas Dittmar, Kurt S. Zänker

CRC Press

332 pages | 11 Color Illus. | 7 B/W Illus.

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Hardback: 9781466577350
pub: 2013-03-01
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This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.

Table of Contents

Cancer Stem Cells – Fact or Fiction?

Cancer Stem Cells of Sarcoma

Role of Hematopoietic Stem and Progenitor Cells in the Origination of Mature B-cell Lymphomas

The Leukemia Stem Cell

CD44 Integrates Signaling in Stem Cell Microenvironments

The Dark Site of Conventional Cancer Therapy - Triggering the Origin of Recurrence Cancer Stem Cells

Current Concepts of How to Eliminate Cancer Stem Cells

Novel Cancer Therapies by Molecular Targeting Distinct Growth Factor Pathways and Drug Resistance-associated Molecules in Cancer- and Metastasis-initiating Cells

Salinomycin, a Candidate Drug for the Elimination of Cancer Stem Cells

Targeting Breast Cancer Stem Cells

Targeting Leukemic Stem Cells by Breaking their Dormancy

About the Editors

Dittmar\, Thomas; Zänker\, Kurt S.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
SCIENCE / Life Sciences / General